Nicotinamide Riboside Supplementation Restores Myocardial Nicotinamide Adenine Dinucleotide Levels, Improves Survival, and Promotes Protective Environment Post Myocardial Infarction

Aims Myocardial infarction (MI) is a major cause of death. Nicotinamide adenine dinucleotide (NAD + ) is a coenzyme in oxidative phosphorylation and substrate of sirtuins and poly-ADP ribose polymerases, enzymes critical for cardiac remodeling post-MI. Decreased NAD + is reported in several heart fa...

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Veröffentlicht in:	Cardiovascular drugs and therapy 2024-12, Vol.38 (6), p.1385-1396
Hauptverfasser:	Tannous, Cynthia, Ghali, Rana, Karoui, Ahmed, Habeichi, Nada J., Amin, Ghadir, Booz, George W., Mericskay, Mathias, Refaat, Marwan, Zouein, Fouad A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Animals Body weight Cardiology Citrate synthase Congestive heart failure Dietary Supplements Disease Models, Animal Heart attacks Kinases Life Sciences Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Myocardial infarction Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardium - metabolism Myocardium - pathology NAD NAD - metabolism Niacinamide - analogs & derivatives Niacinamide - pharmacology Niacinamide - therapeutic use Nicotinamide Nicotinamide adenine dinucleotide Original Article Oxidative phosphorylation Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Poly(ADP-ribose) polymerase Pyridinium Compounds - pharmacology Ribose Sirtuins Survival
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