Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction

Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction

The stimulator of interferon genes (STING) protein plays a crucial role in the activation of the innate immune response. Activation of STING is initiated by cyclic dinucleotides (CDNs) which prompted the community to synthesize structural analogues to enhance their biological properties. We present...

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Veröffentlicht in:Organic letters 2024-02, Vol.26 (4), p.819-823
Hauptverfasser: Amador, Romain, Vasseur, Jean-Jacques, Birkuš, Gabriel, Bignon, Emmanuelle, Monari, Antonio, Clavé, Guillaume, Smietana, Michael
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container_end_page 823
container_issue 4
container_start_page 819
container_title Organic letters
container_volume 26
creator Amador, Romain
Vasseur, Jean-Jacques
Birkuš, Gabriel
Bignon, Emmanuelle
Monari, Antonio
Clavé, Guillaume
Smietana, Michael
description The stimulator of interferon genes (STING) protein plays a crucial role in the activation of the innate immune response. Activation of STING is initiated by cyclic dinucleotides (CDNs) which prompted the community to synthesize structural analogues to enhance their biological properties. We present here the synthesis and biological evaluation of four novel CDN analogues composed of an N-acylsulfonamide linkage. These CDNs were obtained in high overall yields via the sulfo-click reaction as a key step.
doi_str_mv 10.1021/acs.orglett.3c03908
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title Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction
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