Distinct mechanisms mediate pacemaker dysfunction associated with catecholaminergic polymorphic ventricular tachycardia mutations: Insights from computational modeling

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress-induced ventricular arrhythmia associated with rhythm disturbance and impaired sinoatrial node cell (SANC) automaticity (pauses). Mutations associated with dysfunction of Ca2+-related mechanisms have been shown to be present in...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2020-06, Vol.143, p.85-95
Hauptverfasser:	Arbel-Ganon, Limor, Behar, Joachim A., Gómez, Ana María, Yaniv, Yael
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiac diseases Coupled-clock Life Sciences Mutations Numerical model Pacemaker cell Sinoatrial node
Online-Zugang:	Volltext
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