Mass spectrometry for the detection of bioterrorism agents: from environmental to clinical applications

In the current context of international conflicts and localized terrorist actions, there is unfortunately a permanent threat of attacks with unconventional warfare agents. Among these, biological agents such as toxins, microorganisms, and viruses deserve particular attention owing to their ease of p...

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Veröffentlicht in:Journal of mass spectrometry. 2016-03, Vol.51 (3), p.183-199
Hauptverfasser: Duriez, Elodie, Armengaud, Jean, Fenaille, François, Ezan, Eric
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container_title Journal of mass spectrometry.
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creator Duriez, Elodie
Armengaud, Jean
Fenaille, François
Ezan, Eric
description In the current context of international conflicts and localized terrorist actions, there is unfortunately a permanent threat of attacks with unconventional warfare agents. Among these, biological agents such as toxins, microorganisms, and viruses deserve particular attention owing to their ease of production and dissemination. Mass spectrometry (MS)‐based techniques for the detection and quantification of biological agents have a decisive role to play for countermeasures in a scenario of biological attacks. The application of MS to every field of both organic and macromolecular species has in recent years been revolutionized by the development of soft ionization techniques (MALDI and ESI), and by the continuous development of MS technologies (high resolution, accurate mass HR/AM instruments, novel analyzers, hybrid configurations). New possibilities have emerged for exquisite specific and sensitive detection of biological warfare agents. MS‐based strategies for clinical application can now address a wide range of analytical questions mainly including issues related to the complexity of biological samples and their available volume. Multiplexed toxin detection, discovery of new markers through omics approaches, and identification of untargeted microbiological or of novel molecular targets are examples of applications. In this paper, we will present these technological advances along with the novel perspectives offered by omics approaches to clinical detection and follow‐up. Copyright © 2016 John Wiley & Sons, Ltd.
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subjects advanced MS technology
Analyzers
Bacterial Proteins - analysis
Bacterial Proteins - chemistry
Biological
Biological Warfare Agents
biological weapons
Biomarkers - analysis
Biomarkers - chemistry
Bioterrorism
detection
Ionization
Life Sciences
Mass spectrometry
Mass Spectrometry - methods
Multiplexing
quantification
Toxins
Unconventional warfare
Viruses
title Mass spectrometry for the detection of bioterrorism agents: from environmental to clinical applications
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