Dynamic Uni- and Multicellular Patterns Encode Biphasic Activity in Pancreatic Islets

Biphasic secretion is an autonomous feature of many endocrine micro-organs to fulfill physiological demands. The biphasic activity of islet β-cells maintains glucose homeostasis and is altered in type 2 diabetes. Nevertheless, underlying cellular or multicellular functional organizations are only pa...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2021-04, Vol.70 (4), p.878-888
Hauptverfasser:	Jaffredo, Manon, Bertin, Eléonore, Pirog, Antoine, Puginier, Emilie, Gaitan, Julien, Oucherif, Sandra, Lebreton, Fanny, Bosco, Domenico, Catargi, Bogdan, Cattaert, Daniel, Renaud, Sylvie, Lang, Jochen, Raoux, Matthieu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Beta cells Cell activation Diabetes Diabetes mellitus (non-insulin dependent) Glucagon Glucagon-like peptide 1 Homeostasis Life Sciences Pancreas Physiology Synchronization
Online-Zugang:	Volltext
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