Beryllium in exhaled breath condensate as a biomarker of occupational exposure in a primary aluminum production plant
Low beryllium exposure can induce pulmonary granulomatosis, so called berylliosis. For occupational health monitoring, it is more relevant to assess the internal dose of Be received by the lungs than urinary or atmospheric Be. Exhaled breath condensate (EBC) is a matrix collected non-invasively that...
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| Veröffentlicht in: | International journal of hygiene and environmental health 2016-01, Vol.219 (1), p.40-47 |
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| creator | Hulo, Sébastien Radauceanu, Anca Chérot-Kornobis, Nathalie Howsam, Mike Vacchina, Véronique De Broucker, Virginie Rousset, Davy Grzebyk, Michel Dziurla, Mathieu Sobaszek, Annie Edme, Jean-Louis |
| description | Low beryllium exposure can induce pulmonary granulomatosis, so called berylliosis. For occupational health monitoring, it is more relevant to assess the internal dose of Be received by the lungs than urinary or atmospheric Be. Exhaled breath condensate (EBC) is a matrix collected non-invasively that derives from the airway lining fluid. EBC beryllium (Be) levels were evaluated as a marker of occupational exposure in a primary aluminum production plant.
We collected urine and EBC from controls and workers recently exposed to beryllium in the pot room and the anode repair sectors, and calculated a cumulative beryllium exposure index (CBEI) summing the number of years of employment in each task and multiplying by the estimated average beryllium exposure for the task. Concentrations of beryllium and aluminum were measured in EBC (Be-EBC and Al-EBC) and in urine (Be-U and Al-U) by ICP-MS.
We have shown that it was possible to measure Be and Al in workers’ EBC. Compared with controls and after adjustment for smoking status, levels of Be-EBC and Al-EBC were higher in pot room workers and exposed subjects, respectively. Due to its relationship with CBEI, but not with Be-U, it appears that Be-EBC could be a promising marker of occupational exposure and provide additional toxicokinetic information in occupational health studies. |
| doi_str_mv | 10.1016/j.ijheh.2015.08.003 |
| format | Article |
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We collected urine and EBC from controls and workers recently exposed to beryllium in the pot room and the anode repair sectors, and calculated a cumulative beryllium exposure index (CBEI) summing the number of years of employment in each task and multiplying by the estimated average beryllium exposure for the task. Concentrations of beryllium and aluminum were measured in EBC (Be-EBC and Al-EBC) and in urine (Be-U and Al-U) by ICP-MS.
We have shown that it was possible to measure Be and Al in workers’ EBC. Compared with controls and after adjustment for smoking status, levels of Be-EBC and Al-EBC were higher in pot room workers and exposed subjects, respectively. Due to its relationship with CBEI, but not with Be-U, it appears that Be-EBC could be a promising marker of occupational exposure and provide additional toxicokinetic information in occupational health studies.</description><identifier>ISSN: 1438-4639</identifier><identifier>EISSN: 1618-131X</identifier><identifier>DOI: 10.1016/j.ijheh.2015.08.003</identifier><identifier>PMID: 26306830</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adult ; Aluminum - metabolism ; Berylliosis - etiology ; Berylliosis - metabolism ; Beryllium ; Beryllium - metabolism ; Biomarkers - metabolism ; Biomonitoring ; Breath Tests ; Employment ; Environmental Monitoring - standards ; Exhalation ; Exhaled breath condensate ; Female ; Humans ; Life Sciences ; Lung - drug effects ; Lung - metabolism ; Lung - pathology ; Lung internal dose ; Male ; Manufacturing Industry ; Middle Aged ; Occupational Exposure - adverse effects ; Occupational Exposure - analysis ; Occupational exposure assessment ; Work</subject><ispartof>International journal of hygiene and environmental health, 2016-01, Vol.219 (1), p.40-47</ispartof><rights>2015 Elsevier GmbH</rights><rights>Copyright © 2015 Elsevier GmbH. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-d11064eebcf492d1af66c3e3908f70542f2a9e17dfcac32415976bfe63aa2a93</citedby><cites>FETCH-LOGICAL-c496t-d11064eebcf492d1af66c3e3908f70542f2a9e17dfcac32415976bfe63aa2a93</cites><orcidid>0000-0002-6344-8908</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijheh.2015.08.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26306830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04353196$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Hulo, Sébastien</creatorcontrib><creatorcontrib>Radauceanu, Anca</creatorcontrib><creatorcontrib>Chérot-Kornobis, Nathalie</creatorcontrib><creatorcontrib>Howsam, Mike</creatorcontrib><creatorcontrib>Vacchina, Véronique</creatorcontrib><creatorcontrib>De Broucker, Virginie</creatorcontrib><creatorcontrib>Rousset, Davy</creatorcontrib><creatorcontrib>Grzebyk, Michel</creatorcontrib><creatorcontrib>Dziurla, Mathieu</creatorcontrib><creatorcontrib>Sobaszek, Annie</creatorcontrib><creatorcontrib>Edme, Jean-Louis</creatorcontrib><title>Beryllium in exhaled breath condensate as a biomarker of occupational exposure in a primary aluminum production plant</title><title>International journal of hygiene and environmental health</title><addtitle>Int J Hyg Environ Health</addtitle><description>Low beryllium exposure can induce pulmonary granulomatosis, so called berylliosis. For occupational health monitoring, it is more relevant to assess the internal dose of Be received by the lungs than urinary or atmospheric Be. Exhaled breath condensate (EBC) is a matrix collected non-invasively that derives from the airway lining fluid. EBC beryllium (Be) levels were evaluated as a marker of occupational exposure in a primary aluminum production plant.
We collected urine and EBC from controls and workers recently exposed to beryllium in the pot room and the anode repair sectors, and calculated a cumulative beryllium exposure index (CBEI) summing the number of years of employment in each task and multiplying by the estimated average beryllium exposure for the task. Concentrations of beryllium and aluminum were measured in EBC (Be-EBC and Al-EBC) and in urine (Be-U and Al-U) by ICP-MS.
We have shown that it was possible to measure Be and Al in workers’ EBC. Compared with controls and after adjustment for smoking status, levels of Be-EBC and Al-EBC were higher in pot room workers and exposed subjects, respectively. Due to its relationship with CBEI, but not with Be-U, it appears that Be-EBC could be a promising marker of occupational exposure and provide additional toxicokinetic information in occupational health studies.</description><subject>Adult</subject><subject>Aluminum - metabolism</subject><subject>Berylliosis - etiology</subject><subject>Berylliosis - metabolism</subject><subject>Beryllium</subject><subject>Beryllium - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>Biomonitoring</subject><subject>Breath Tests</subject><subject>Employment</subject><subject>Environmental Monitoring - standards</subject><subject>Exhalation</subject><subject>Exhaled breath condensate</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lung - drug effects</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>Lung internal dose</subject><subject>Male</subject><subject>Manufacturing Industry</subject><subject>Middle Aged</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - analysis</subject><subject>Occupational exposure assessment</subject><subject>Work</subject><issn>1438-4639</issn><issn>1618-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAUhC1ERUvhFyAhH-GQ1C9OnOTAoa2AIq3USw-9WY79rPWSxMGOK_rvcdilR0627G_mjT2EfABWAgNxdSjdYY_7smLQlKwrGeOvyAUI6Arg8Pg672veFbXg_Tl5G-OBsQpY178h55XgTHScXZB0g-F5HF2aqJsp_t6rEQ0dAqp1T7WfDc5RrUhVpIoOzk8q_MRAvaVe67So1flZjVm4-JgCbiaKLsFl7pmqMU1uztZL8CbpjaXLqOb1HTmzaoz4_rRekodvXx9u74rd_fcft9e7Qte9WAsDwESNOGhb95UBZYXQHHnPOtuypq5spXqE1litNK9qaPpWDBYFVyrf8Evy-WibXyVPoaRXTt5d7-R2xmrecOjFE2T205HNWX8ljKucXNQ45rjoU5TQAXRtAy3PKD-iOvgYA9oXb2Byq0Ye5N9q5FaNZJ3M1WTVx9OANExoXjT_usjAlyOA-UeeHAYZtcNZo3EB9SqNd_8d8AdTzaIj</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Hulo, Sébastien</creator><creator>Radauceanu, Anca</creator><creator>Chérot-Kornobis, Nathalie</creator><creator>Howsam, Mike</creator><creator>Vacchina, Véronique</creator><creator>De Broucker, Virginie</creator><creator>Rousset, Davy</creator><creator>Grzebyk, Michel</creator><creator>Dziurla, Mathieu</creator><creator>Sobaszek, Annie</creator><creator>Edme, Jean-Louis</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6344-8908</orcidid></search><sort><creationdate>20160101</creationdate><title>Beryllium in exhaled breath condensate as a biomarker of occupational exposure in a primary aluminum production plant</title><author>Hulo, Sébastien ; Radauceanu, Anca ; Chérot-Kornobis, Nathalie ; Howsam, Mike ; Vacchina, Véronique ; De Broucker, Virginie ; Rousset, Davy ; Grzebyk, Michel ; Dziurla, Mathieu ; Sobaszek, Annie ; Edme, Jean-Louis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-d11064eebcf492d1af66c3e3908f70542f2a9e17dfcac32415976bfe63aa2a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aluminum - metabolism</topic><topic>Berylliosis - etiology</topic><topic>Berylliosis - metabolism</topic><topic>Beryllium</topic><topic>Beryllium - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>Biomonitoring</topic><topic>Breath Tests</topic><topic>Employment</topic><topic>Environmental Monitoring - standards</topic><topic>Exhalation</topic><topic>Exhaled breath condensate</topic><topic>Female</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Lung - drug effects</topic><topic>Lung - metabolism</topic><topic>Lung - pathology</topic><topic>Lung internal dose</topic><topic>Male</topic><topic>Manufacturing Industry</topic><topic>Middle Aged</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational Exposure - analysis</topic><topic>Occupational exposure assessment</topic><topic>Work</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hulo, Sébastien</creatorcontrib><creatorcontrib>Radauceanu, Anca</creatorcontrib><creatorcontrib>Chérot-Kornobis, Nathalie</creatorcontrib><creatorcontrib>Howsam, Mike</creatorcontrib><creatorcontrib>Vacchina, Véronique</creatorcontrib><creatorcontrib>De Broucker, Virginie</creatorcontrib><creatorcontrib>Rousset, Davy</creatorcontrib><creatorcontrib>Grzebyk, Michel</creatorcontrib><creatorcontrib>Dziurla, Mathieu</creatorcontrib><creatorcontrib>Sobaszek, Annie</creatorcontrib><creatorcontrib>Edme, Jean-Louis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>International journal of hygiene and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hulo, Sébastien</au><au>Radauceanu, Anca</au><au>Chérot-Kornobis, Nathalie</au><au>Howsam, Mike</au><au>Vacchina, Véronique</au><au>De Broucker, Virginie</au><au>Rousset, Davy</au><au>Grzebyk, Michel</au><au>Dziurla, Mathieu</au><au>Sobaszek, Annie</au><au>Edme, Jean-Louis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beryllium in exhaled breath condensate as a biomarker of occupational exposure in a primary aluminum production plant</atitle><jtitle>International journal of hygiene and environmental health</jtitle><addtitle>Int J Hyg Environ Health</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>219</volume><issue>1</issue><spage>40</spage><epage>47</epage><pages>40-47</pages><issn>1438-4639</issn><eissn>1618-131X</eissn><abstract>Low beryllium exposure can induce pulmonary granulomatosis, so called berylliosis. For occupational health monitoring, it is more relevant to assess the internal dose of Be received by the lungs than urinary or atmospheric Be. Exhaled breath condensate (EBC) is a matrix collected non-invasively that derives from the airway lining fluid. EBC beryllium (Be) levels were evaluated as a marker of occupational exposure in a primary aluminum production plant.
We collected urine and EBC from controls and workers recently exposed to beryllium in the pot room and the anode repair sectors, and calculated a cumulative beryllium exposure index (CBEI) summing the number of years of employment in each task and multiplying by the estimated average beryllium exposure for the task. Concentrations of beryllium and aluminum were measured in EBC (Be-EBC and Al-EBC) and in urine (Be-U and Al-U) by ICP-MS.
We have shown that it was possible to measure Be and Al in workers’ EBC. Compared with controls and after adjustment for smoking status, levels of Be-EBC and Al-EBC were higher in pot room workers and exposed subjects, respectively. Due to its relationship with CBEI, but not with Be-U, it appears that Be-EBC could be a promising marker of occupational exposure and provide additional toxicokinetic information in occupational health studies.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>26306830</pmid><doi>10.1016/j.ijheh.2015.08.003</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6344-8908</orcidid></addata></record> |
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| subjects | Adult Aluminum - metabolism Berylliosis - etiology Berylliosis - metabolism Beryllium Beryllium - metabolism Biomarkers - metabolism Biomonitoring Breath Tests Employment Environmental Monitoring - standards Exhalation Exhaled breath condensate Female Humans Life Sciences Lung - drug effects Lung - metabolism Lung - pathology Lung internal dose Male Manufacturing Industry Middle Aged Occupational Exposure - adverse effects Occupational Exposure - analysis Occupational exposure assessment Work |
| title | Beryllium in exhaled breath condensate as a biomarker of occupational exposure in a primary aluminum production plant |
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