Systemic Convergent Multitarget Interactions of Plant Polyphenols Revealed by Affinity-Based Protein Profiling of Bone Cells Using C‑Glucosidic Vescal(ag)in-Bearing Chemoproteomic Probes

The ellagitannins vescalagin and vescalin, known as actin-dependent inhibitors of osteoclastic bone resorption, were mounted onto chemical probes to explore their interactions with bone cell proteins by means of affinity-based chemoproteomics and bioinformatics. The chemical reactivity of the pyroga...

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Veröffentlicht in:	ACS chemical biology 2023-12, Vol.18 (12), p.2495-2505
Hauptverfasser:	Kempf, Karl, Capello, Yoan, Melhem, Rana, Lescoat, Claire, Kempf, Oxana, Cornu, Anaëlle, Fremaux, Isabelle, Chaignepain, Stéphane, Groppi, Alexis, Nikolski, Macha, Deffieux, Denis, Génot, Elisabeth, Quideau, Stéphane
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Bone Resorption - metabolism Cell Differentiation Chemical Sciences Glucosides - metabolism Humans Hydrolyzable Tannins - metabolism Life Sciences Osteoblasts - metabolism Polyphenols - metabolism
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