Cumulative detection of anal high-grade squamous intraepithelial lesions over two-year follow-up in men who have sex with men living with HIV in France
We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSIL) in men who have sex with men living with HIV who underwent three visits over two years, with cytology and high-resolution anoscopy (HRA), within the ANRS-EP57-APACHES study. Cumulative HSIL d...
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| Veröffentlicht in: | The Journal of infectious diseases 2023-11 |
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| creator | Combes, Jean-Damien Didelot, Jean-Michel Radenne, Sylvie Zaegel-Faucher, Olivia Lesage, Anne-Carole Siproudhis, Laurent Piroth, Lionel Marchand, Lucie Heard, Isabelle Hoyeau, Nadia Henno, Sébastien Darragh, Teresa M Alberts, Catharina J Clifford, Gary M Etienney, Isabelle |
| description | We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSIL) in men who have sex with men living with HIV who underwent three visits over two years, with cytology and high-resolution anoscopy (HRA), within the ANRS-EP57-APACHES study. Cumulative HSIL detection was 33% (134/410), of which 48% were detected at baseline. HSIL detection varied considerably by center (13-51%). Strongest HSIL determinants were baseline HPV16 (adjusted odds ratio [aOR] 8.2; 95% confidence interval [95%CI] 3.6-18.9), and p16/Ki67 (aOR 4.6; 95%CI 2.3-9.1). Repeat annual cytology and HRA improved HSIL detection but did not fully compensate between-center heterogeneity. |
| doi_str_mv | 10.1093/infdis/jiad506 |
| format | Article |
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Cumulative HSIL detection was 33% (134/410), of which 48% were detected at baseline. HSIL detection varied considerably by center (13-51%). Strongest HSIL determinants were baseline HPV16 (adjusted odds ratio [aOR] 8.2; 95% confidence interval [95%CI] 3.6-18.9), and p16/Ki67 (aOR 4.6; 95%CI 2.3-9.1). Repeat annual cytology and HRA improved HSIL detection but did not fully compensate between-center heterogeneity.</description><identifier>ISSN: 1537-6613</identifier><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiad506</identifier><identifier>PMID: 37970975</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Life Sciences</subject><ispartof>The Journal of infectious diseases, 2023-11</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. 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Cumulative HSIL detection was 33% (134/410), of which 48% were detected at baseline. HSIL detection varied considerably by center (13-51%). Strongest HSIL determinants were baseline HPV16 (adjusted odds ratio [aOR] 8.2; 95% confidence interval [95%CI] 3.6-18.9), and p16/Ki67 (aOR 4.6; 95%CI 2.3-9.1). 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Cumulative HSIL detection was 33% (134/410), of which 48% were detected at baseline. HSIL detection varied considerably by center (13-51%). Strongest HSIL determinants were baseline HPV16 (adjusted odds ratio [aOR] 8.2; 95% confidence interval [95%CI] 3.6-18.9), and p16/Ki67 (aOR 4.6; 95%CI 2.3-9.1). Repeat annual cytology and HRA improved HSIL detection but did not fully compensate between-center heterogeneity.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>37970975</pmid><doi>10.1093/infdis/jiad506</doi><orcidid>https://orcid.org/0000-0001-7534-333X</orcidid><orcidid>https://orcid.org/0000-0002-2575-6790</orcidid><orcidid>https://orcid.org/0000-0001-7789-7264</orcidid></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Life Sciences |
| title | Cumulative detection of anal high-grade squamous intraepithelial lesions over two-year follow-up in men who have sex with men living with HIV in France |
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