Challenges and directions in studying cell–cell communication by extracellular vesicles
Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. They have important roles in numerous physiological and pathological processes, and show considerable promise as novel biomarkers of disease, as therapeutic agents and as drug delivery veh...
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| Veröffentlicht in: | Nature reviews. Molecular cell biology 2022-05, Vol.23 (5), p.369-382 |
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| creator | van Niel, Guillaume Carter, David R. F. Clayton, Aled Lambert, Daniel W. Raposo, Graça Vader, Pieter |
| description | Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. They have important roles in numerous physiological and pathological processes, and show considerable promise as novel biomarkers of disease, as therapeutic agents and as drug delivery vehicles. Intriguingly, however, understanding of the cellular and molecular mechanisms that govern the many observed functions of EVs remains far from comprehensive, at least partly due to technical challenges in working with these small messengers. Here, we highlight areas of consensus as well as contentious issues in our understanding of the intracellular and intercellular journey of EVs: from biogenesis, release and dynamics in the extracellular space, to interaction with and uptake by recipient cells. We define knowledge gaps, identify key questions and challenges, and make recommendations on how to address these.
Extracellular vesicles (EVs) mediate cell–cell communication in physiology and pathology but many questions remain about the mechanisms governing their delivery to recipient cells. This Expert Recommendation article highlights areas of progress and challenges in establishing the importance of EV-mediated communication in vivo. |
| doi_str_mv | 10.1038/s41580-022-00460-3 |
| format | Article |
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Extracellular vesicles (EVs) mediate cell–cell communication in physiology and pathology but many questions remain about the mechanisms governing their delivery to recipient cells. 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Molecular cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Niel, Guillaume</au><au>Carter, David R. F.</au><au>Clayton, Aled</au><au>Lambert, Daniel W.</au><au>Raposo, Graça</au><au>Vader, Pieter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Challenges and directions in studying cell–cell communication by extracellular vesicles</atitle><jtitle>Nature reviews. Molecular cell biology</jtitle><stitle>Nat Rev Mol Cell Biol</stitle><addtitle>Nat Rev Mol Cell Biol</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>23</volume><issue>5</issue><spage>369</spage><epage>382</epage><pages>369-382</pages><issn>1471-0072</issn><eissn>1471-0080</eissn><abstract>Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. 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| subjects | 631/80/304 631/80/313 631/80/86 Biochemistry Biological Transport Biomarkers Biomarkers - metabolism Biomedical and Life Sciences Cancer Research Cell Biology Cell Communication Cell interactions Chemical compounds Communication Developmental Biology Drug delivery Drug Delivery Systems Expert Recommendation Extracellular vesicles Extracellular Vesicles - metabolism Life Sciences Molecular modelling Pharmacology Physiology Questions Stem Cells Vesicles |
| title | Challenges and directions in studying cell–cell communication by extracellular vesicles |
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