High‐Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC‐SIGN and Langerin

The “carbohydrate chemical mimicry” exhibited by sp2‐iminosugars has been utilized to develop practical syntheses for analogs of the branched high‐mannose‐type oligosaccharides (HMOs) Man3 and Man5. In these compounds, the terminal nonreducing Man residues have been substituted with 5,6‐oxomethylide...

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Veröffentlicht in:	Chemistry : a European journal 2024-01, Vol.30 (2), p.e202303041-n/a
Hauptverfasser:	Herrera‐González, Irene, González‐Cuesta, Manuel, Thépaut, Michel, Laigre, Eugénie, Goyard, David, Rojo, Javier, García Fernández, José M., Fieschi, Franck, Renaudet, Olivier, Nieto, Pedro M., Ortiz Mellet, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Carbohydrates Chemical Sciences Chemistry Concanavalin A Concanavalin A - metabolism Conformation Epitopes glycomimetics high-mannose oligosaccharides Humans Lectins Lectins, C-Type - metabolism Mannose Mannose - chemistry Mannose-Binding Lectins - chemistry Mimicry Monosaccharides multivalency NMR Nuclear magnetic resonance Oligosaccharides Oligosaccharides - chemistry Phytochemicals Surface plasmon resonance
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