Chronic intermittent hypoxia‐induced cardiovascular and renal dysfunction: from adaptation to maladaptation

Chronic intermittent hypoxia (CIH) is the dominant pathological feature of human obstructive sleep apnoea (OSA), which is highly prevalent and associated with cardiovascular and renal diseases. CIH causes hypertension, centred on sympathetic nervous overactivity, which persists following removal of...

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Veröffentlicht in:	The Journal of physiology 2023-12, Vol.601 (24), p.5553-5577
Hauptverfasser:	Arnaud, Claire, Billoir, Emma, Melo Junior, Antonio F., Pereira, Sofia A., O'Halloran, Ken D., Monteiro, Emilia C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apnea Apoptosis Arteriosclerosis Aryl hydrocarbon receptors Blood pressure Calcium (mitochondrial) cardiac arrythmias Cardiovascular System Caspase chronic intermittent hypoxia endothelial dysfunction Humans Hypertension Hypoxia hypoxia‐inducible factor Inflammation Kidney - pathology kidney disease Kidney diseases Life Sciences Molecular modelling Muscle contraction Myocardium Nitric oxide obstructive sleep apnoea Oxidants Oxidative stress Phenotypes Renal function Signal transduction Sleep apnea Sleep Apnea, Obstructive - complications Sleep disorders TLR4 protein Toll-like receptors Vagus nerve
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