Non‐Contrast‐Enhanced Functional Lung MRI to Evaluate Treatment Response of Allergic Bronchopulmonary Aspergillosis in Patients With Cystic Fibrosis: A Pilot Study
Background Allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) patients is associated with severe lung damage and requires specific therapeutic management. Repeated imaging is recommended to both diagnose and follow‐up response to treatment of ABPA in CF. However, high risk of cum...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2024-03, Vol.59 (3), p.909-919 |
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| creator | Benlala, Ilyes Klaar, Rabea Gaass, Thomas Macey, Julie Bui, Stéphanie Senneville, Baudouin Denis De Berger, Patrick Laurent, François Dournes, Gael Dinkel, Julien |
| description | Background
Allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) patients is associated with severe lung damage and requires specific therapeutic management. Repeated imaging is recommended to both diagnose and follow‐up response to treatment of ABPA in CF. However, high risk of cumulative radiation exposure requires evaluation of free‐radiation techniques in the follow‐up of CF patients with ABPA.
Purpose
To evaluate whether Fourier decomposition (FD) functional lung MRI can detect response to treatment of ABPA in CF patients.
Study Type
Retrospective longitudinal.
Population
Twelve patients (7M, median‐age:14 years) with CF and ABPA with pre‐ and post‐treatment MRI.
Field Strength/Sequence
2D‐balanced‐steady‐state free‐precession (bSSFP) sequence with FD at 1.5T.
Assessment
Ventilation‐weighted (V) and perfusion‐weighted (Q) maps were obtained after FD processing of 2D‐coronal bSSFP time‐resolved images acquired before and 3–9 months after treatment. Defects extent was assessed on the functional maps using a qualitative semi‐quantitative score (0 = absence/negligible, 1 = 50%). Mean and coefficient of variation (CV) of the ventilation signal‐intensity (VSI) and the perfusion signal‐intensity (QSI) were calculated. Measurements were performed independently by three readers and averaged. Inter‐reader reproducibility of the measurements was assessed. Pulmonary function tests (PFTs) were performed within 1 week of both MRI studies as markers of the airflow‐limitation severity.
Statistical Tests
Comparisons of medians were performed using the paired Wilcoxon‐test. Reproducibility was assessed using intraclass correlation coefficient (ICC). Correlations between MRI and PFT parameters were assessed using the Spearman‐test (rho correlation‐coefficient). A P‐value 0.90, while the ICCs of the quantitative measurements was almost perfect (>0.99). Changes in VSI_cv and QSI_cv before and after treatment correlated inversely with changes of FEV1%p (rho = −0.68 for both).
Data Conclusion
Non‐contrast‐enhanced FD lung MRI has potential to reproducibly assess response to treatment of ABPA in CF patients and correlates with PF |
| doi_str_mv | 10.1002/jmri.28844 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_04268654v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2922855213</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4274-acc456087234e382fe0793be6e53e2a8d3ea845781825f95f37d40d1e248f6df3</originalsourceid><addsrcrecordid>eNp9kc9uEzEQxlcIRP_AhQdAlrgAUor_7jq9LVFCiwJUpYij5ezONo689mJ7W-XGI_AWvBdPgkNKDxw4zWjmN59G31cUzwg-IRjTN5s-mBMqJecPikMiKJ1QIcuHuceCTYjE1UFxFOMGYzydcvG4OGAVLQXn5LD4-dG7X99_zLxLQceU27lba9dAixaja5LxTlu0HN01-nB5jpJH8xttR50AXQXQqQeX0CXEwbsIyHeothbCtWnQ2-Bds_bDaPusEbaojsNuY62PJiLj0IVOJp9H9NWkNZptY8pnC7MKO-AU1ejCWJ_Q5zS22yfFo07bCE_v6nHxZTG_mp1Nlp_enc_q5aThtOIT3TRclFhWlHFgknaAqylbQQmCAdWyZaAlF5UkkopuKjpWtRy3BCiXXdl27Lh4tddda6uGYPr8ufLaqLN6qXYzzGkps3k3JLMv9-wQ_LcRYlK9iQ1Yqx34MSoqKWVVKSXO6It_0I0fQ7Y2U1NKpRCUsEy93lNNtiAG6O4_IFjtola7qNWfqDP8_E5yXPXQ3qN_s80A2QO3xsL2P1LqfY52L_obJty2oA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2922855213</pqid></control><display><type>article</type><title>Non‐Contrast‐Enhanced Functional Lung MRI to Evaluate Treatment Response of Allergic Bronchopulmonary Aspergillosis in Patients With Cystic Fibrosis: A Pilot Study</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Benlala, Ilyes ; Klaar, Rabea ; Gaass, Thomas ; Macey, Julie ; Bui, Stéphanie ; Senneville, Baudouin Denis De ; Berger, Patrick ; Laurent, François ; Dournes, Gael ; Dinkel, Julien</creator><creatorcontrib>Benlala, Ilyes ; Klaar, Rabea ; Gaass, Thomas ; Macey, Julie ; Bui, Stéphanie ; Senneville, Baudouin Denis De ; Berger, Patrick ; Laurent, François ; Dournes, Gael ; Dinkel, Julien</creatorcontrib><description>Background
Allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) patients is associated with severe lung damage and requires specific therapeutic management. Repeated imaging is recommended to both diagnose and follow‐up response to treatment of ABPA in CF. However, high risk of cumulative radiation exposure requires evaluation of free‐radiation techniques in the follow‐up of CF patients with ABPA.
Purpose
To evaluate whether Fourier decomposition (FD) functional lung MRI can detect response to treatment of ABPA in CF patients.
Study Type
Retrospective longitudinal.
Population
Twelve patients (7M, median‐age:14 years) with CF and ABPA with pre‐ and post‐treatment MRI.
Field Strength/Sequence
2D‐balanced‐steady‐state free‐precession (bSSFP) sequence with FD at 1.5T.
Assessment
Ventilation‐weighted (V) and perfusion‐weighted (Q) maps were obtained after FD processing of 2D‐coronal bSSFP time‐resolved images acquired before and 3–9 months after treatment. Defects extent was assessed on the functional maps using a qualitative semi‐quantitative score (0 = absence/negligible, 1 = <50%, 2 = >50%). Mean and coefficient of variation (CV) of the ventilation signal‐intensity (VSI) and the perfusion signal‐intensity (QSI) were calculated. Measurements were performed independently by three readers and averaged. Inter‐reader reproducibility of the measurements was assessed. Pulmonary function tests (PFTs) were performed within 1 week of both MRI studies as markers of the airflow‐limitation severity.
Statistical Tests
Comparisons of medians were performed using the paired Wilcoxon‐test. Reproducibility was assessed using intraclass correlation coefficient (ICC). Correlations between MRI and PFT parameters were assessed using the Spearman‐test (rho correlation‐coefficient). A P‐value <0.05 was considered as significant.
Results
Defects extent on both V and Q maps showed a significant reduction after ABPA treatment (4.25 vs. 1.92 for V‐defect‐score and 5 vs. 2.75 for Q‐defect‐score). VSI_mean was significantly increased after treatment (280 vs. 167). Qualitative analyses reproducibility showed an ICC > 0.90, while the ICCs of the quantitative measurements was almost perfect (>0.99). Changes in VSI_cv and QSI_cv before and after treatment correlated inversely with changes of FEV1%p (rho = −0.68 for both).
Data Conclusion
Non‐contrast‐enhanced FD lung MRI has potential to reproducibly assess response to treatment of ABPA in CF patients and correlates with PFT obstructive parameters.
Evidence Level
4
Technical Efficacy
Stage 3</description><identifier>ISSN: 1053-1807</identifier><identifier>ISSN: 1522-2586</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.28844</identifier><identifier>PMID: 37265441</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>ABPA ; Air flow ; Allergic bronchopulmonary aspergillosis ; Allergies ; Allergology ; Aspergillosis ; Bioengineering ; Coefficient of variation ; Correlation coefficient ; Correlation coefficients ; Cystic fibrosis ; Defects ; Disease management ; Evaluation ; Field strength ; Fourier decomposition ; Functional magnetic resonance imaging ; Fungal infections ; Human health and pathology ; Image acquisition ; Imaging ; Immunology ; Infectious diseases ; Life Sciences ; Lungs ; Magnetic resonance imaging ; Mathematical analysis ; Mean ; Parameters ; Perfusion ; Population studies ; Pulmonary functions ; Pulmonology and respiratory tract ; Qualitative analysis ; Radiation ; Radiation effects ; Reproducibility ; Respiratory function ; Statistical analysis ; Statistical tests ; Ventilation</subject><ispartof>Journal of magnetic resonance imaging, 2024-03, Vol.59 (3), p.909-919</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.</rights><rights>2023 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4274-acc456087234e382fe0793be6e53e2a8d3ea845781825f95f37d40d1e248f6df3</citedby><cites>FETCH-LOGICAL-c4274-acc456087234e382fe0793be6e53e2a8d3ea845781825f95f37d40d1e248f6df3</cites><orcidid>0000-0002-0251-6639 ; 0000-0001-5284-8474</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.28844$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.28844$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37265441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04268654$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Benlala, Ilyes</creatorcontrib><creatorcontrib>Klaar, Rabea</creatorcontrib><creatorcontrib>Gaass, Thomas</creatorcontrib><creatorcontrib>Macey, Julie</creatorcontrib><creatorcontrib>Bui, Stéphanie</creatorcontrib><creatorcontrib>Senneville, Baudouin Denis De</creatorcontrib><creatorcontrib>Berger, Patrick</creatorcontrib><creatorcontrib>Laurent, François</creatorcontrib><creatorcontrib>Dournes, Gael</creatorcontrib><creatorcontrib>Dinkel, Julien</creatorcontrib><title>Non‐Contrast‐Enhanced Functional Lung MRI to Evaluate Treatment Response of Allergic Bronchopulmonary Aspergillosis in Patients With Cystic Fibrosis: A Pilot Study</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Background
Allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) patients is associated with severe lung damage and requires specific therapeutic management. Repeated imaging is recommended to both diagnose and follow‐up response to treatment of ABPA in CF. However, high risk of cumulative radiation exposure requires evaluation of free‐radiation techniques in the follow‐up of CF patients with ABPA.
Purpose
To evaluate whether Fourier decomposition (FD) functional lung MRI can detect response to treatment of ABPA in CF patients.
Study Type
Retrospective longitudinal.
Population
Twelve patients (7M, median‐age:14 years) with CF and ABPA with pre‐ and post‐treatment MRI.
Field Strength/Sequence
2D‐balanced‐steady‐state free‐precession (bSSFP) sequence with FD at 1.5T.
Assessment
Ventilation‐weighted (V) and perfusion‐weighted (Q) maps were obtained after FD processing of 2D‐coronal bSSFP time‐resolved images acquired before and 3–9 months after treatment. Defects extent was assessed on the functional maps using a qualitative semi‐quantitative score (0 = absence/negligible, 1 = <50%, 2 = >50%). Mean and coefficient of variation (CV) of the ventilation signal‐intensity (VSI) and the perfusion signal‐intensity (QSI) were calculated. Measurements were performed independently by three readers and averaged. Inter‐reader reproducibility of the measurements was assessed. Pulmonary function tests (PFTs) were performed within 1 week of both MRI studies as markers of the airflow‐limitation severity.
Statistical Tests
Comparisons of medians were performed using the paired Wilcoxon‐test. Reproducibility was assessed using intraclass correlation coefficient (ICC). Correlations between MRI and PFT parameters were assessed using the Spearman‐test (rho correlation‐coefficient). A P‐value <0.05 was considered as significant.
Results
Defects extent on both V and Q maps showed a significant reduction after ABPA treatment (4.25 vs. 1.92 for V‐defect‐score and 5 vs. 2.75 for Q‐defect‐score). VSI_mean was significantly increased after treatment (280 vs. 167). Qualitative analyses reproducibility showed an ICC > 0.90, while the ICCs of the quantitative measurements was almost perfect (>0.99). Changes in VSI_cv and QSI_cv before and after treatment correlated inversely with changes of FEV1%p (rho = −0.68 for both).
Data Conclusion
Non‐contrast‐enhanced FD lung MRI has potential to reproducibly assess response to treatment of ABPA in CF patients and correlates with PFT obstructive parameters.
Evidence Level
4
Technical Efficacy
Stage 3</description><subject>ABPA</subject><subject>Air flow</subject><subject>Allergic bronchopulmonary aspergillosis</subject><subject>Allergies</subject><subject>Allergology</subject><subject>Aspergillosis</subject><subject>Bioengineering</subject><subject>Coefficient of variation</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Cystic fibrosis</subject><subject>Defects</subject><subject>Disease management</subject><subject>Evaluation</subject><subject>Field strength</subject><subject>Fourier decomposition</subject><subject>Functional magnetic resonance imaging</subject><subject>Fungal infections</subject><subject>Human health and pathology</subject><subject>Image acquisition</subject><subject>Imaging</subject><subject>Immunology</subject><subject>Infectious diseases</subject><subject>Life Sciences</subject><subject>Lungs</subject><subject>Magnetic resonance imaging</subject><subject>Mathematical analysis</subject><subject>Mean</subject><subject>Parameters</subject><subject>Perfusion</subject><subject>Population studies</subject><subject>Pulmonary functions</subject><subject>Pulmonology and respiratory tract</subject><subject>Qualitative analysis</subject><subject>Radiation</subject><subject>Radiation effects</subject><subject>Reproducibility</subject><subject>Respiratory function</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>Ventilation</subject><issn>1053-1807</issn><issn>1522-2586</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp9kc9uEzEQxlcIRP_AhQdAlrgAUor_7jq9LVFCiwJUpYij5ezONo689mJ7W-XGI_AWvBdPgkNKDxw4zWjmN59G31cUzwg-IRjTN5s-mBMqJecPikMiKJ1QIcuHuceCTYjE1UFxFOMGYzydcvG4OGAVLQXn5LD4-dG7X99_zLxLQceU27lba9dAixaja5LxTlu0HN01-nB5jpJH8xttR50AXQXQqQeX0CXEwbsIyHeothbCtWnQ2-Bds_bDaPusEbaojsNuY62PJiLj0IVOJp9H9NWkNZptY8pnC7MKO-AU1ejCWJ_Q5zS22yfFo07bCE_v6nHxZTG_mp1Nlp_enc_q5aThtOIT3TRclFhWlHFgknaAqylbQQmCAdWyZaAlF5UkkopuKjpWtRy3BCiXXdl27Lh4tddda6uGYPr8ufLaqLN6qXYzzGkps3k3JLMv9-wQ_LcRYlK9iQ1Yqx34MSoqKWVVKSXO6It_0I0fQ7Y2U1NKpRCUsEy93lNNtiAG6O4_IFjtola7qNWfqDP8_E5yXPXQ3qN_s80A2QO3xsL2P1LqfY52L_obJty2oA</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Benlala, Ilyes</creator><creator>Klaar, Rabea</creator><creator>Gaass, Thomas</creator><creator>Macey, Julie</creator><creator>Bui, Stéphanie</creator><creator>Senneville, Baudouin Denis De</creator><creator>Berger, Patrick</creator><creator>Laurent, François</creator><creator>Dournes, Gael</creator><creator>Dinkel, Julien</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><general>Wiley-Blackwell</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-0251-6639</orcidid><orcidid>https://orcid.org/0000-0001-5284-8474</orcidid></search><sort><creationdate>202403</creationdate><title>Non‐Contrast‐Enhanced Functional Lung MRI to Evaluate Treatment Response of Allergic Bronchopulmonary Aspergillosis in Patients With Cystic Fibrosis: A Pilot Study</title><author>Benlala, Ilyes ; Klaar, Rabea ; Gaass, Thomas ; Macey, Julie ; Bui, Stéphanie ; Senneville, Baudouin Denis De ; Berger, Patrick ; Laurent, François ; Dournes, Gael ; Dinkel, Julien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4274-acc456087234e382fe0793be6e53e2a8d3ea845781825f95f37d40d1e248f6df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>ABPA</topic><topic>Air flow</topic><topic>Allergic bronchopulmonary aspergillosis</topic><topic>Allergies</topic><topic>Allergology</topic><topic>Aspergillosis</topic><topic>Bioengineering</topic><topic>Coefficient of variation</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Cystic fibrosis</topic><topic>Defects</topic><topic>Disease management</topic><topic>Evaluation</topic><topic>Field strength</topic><topic>Fourier decomposition</topic><topic>Functional magnetic resonance imaging</topic><topic>Fungal infections</topic><topic>Human health and pathology</topic><topic>Image acquisition</topic><topic>Imaging</topic><topic>Immunology</topic><topic>Infectious diseases</topic><topic>Life Sciences</topic><topic>Lungs</topic><topic>Magnetic resonance imaging</topic><topic>Mathematical analysis</topic><topic>Mean</topic><topic>Parameters</topic><topic>Perfusion</topic><topic>Population studies</topic><topic>Pulmonary functions</topic><topic>Pulmonology and respiratory tract</topic><topic>Qualitative analysis</topic><topic>Radiation</topic><topic>Radiation effects</topic><topic>Reproducibility</topic><topic>Respiratory function</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benlala, Ilyes</creatorcontrib><creatorcontrib>Klaar, Rabea</creatorcontrib><creatorcontrib>Gaass, Thomas</creatorcontrib><creatorcontrib>Macey, Julie</creatorcontrib><creatorcontrib>Bui, Stéphanie</creatorcontrib><creatorcontrib>Senneville, Baudouin Denis De</creatorcontrib><creatorcontrib>Berger, Patrick</creatorcontrib><creatorcontrib>Laurent, François</creatorcontrib><creatorcontrib>Dournes, Gael</creatorcontrib><creatorcontrib>Dinkel, Julien</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benlala, Ilyes</au><au>Klaar, Rabea</au><au>Gaass, Thomas</au><au>Macey, Julie</au><au>Bui, Stéphanie</au><au>Senneville, Baudouin Denis De</au><au>Berger, Patrick</au><au>Laurent, François</au><au>Dournes, Gael</au><au>Dinkel, Julien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non‐Contrast‐Enhanced Functional Lung MRI to Evaluate Treatment Response of Allergic Bronchopulmonary Aspergillosis in Patients With Cystic Fibrosis: A Pilot Study</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2024-03</date><risdate>2024</risdate><volume>59</volume><issue>3</issue><spage>909</spage><epage>919</epage><pages>909-919</pages><issn>1053-1807</issn><issn>1522-2586</issn><eissn>1522-2586</eissn><abstract>Background
Allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) patients is associated with severe lung damage and requires specific therapeutic management. Repeated imaging is recommended to both diagnose and follow‐up response to treatment of ABPA in CF. However, high risk of cumulative radiation exposure requires evaluation of free‐radiation techniques in the follow‐up of CF patients with ABPA.
Purpose
To evaluate whether Fourier decomposition (FD) functional lung MRI can detect response to treatment of ABPA in CF patients.
Study Type
Retrospective longitudinal.
Population
Twelve patients (7M, median‐age:14 years) with CF and ABPA with pre‐ and post‐treatment MRI.
Field Strength/Sequence
2D‐balanced‐steady‐state free‐precession (bSSFP) sequence with FD at 1.5T.
Assessment
Ventilation‐weighted (V) and perfusion‐weighted (Q) maps were obtained after FD processing of 2D‐coronal bSSFP time‐resolved images acquired before and 3–9 months after treatment. Defects extent was assessed on the functional maps using a qualitative semi‐quantitative score (0 = absence/negligible, 1 = <50%, 2 = >50%). Mean and coefficient of variation (CV) of the ventilation signal‐intensity (VSI) and the perfusion signal‐intensity (QSI) were calculated. Measurements were performed independently by three readers and averaged. Inter‐reader reproducibility of the measurements was assessed. Pulmonary function tests (PFTs) were performed within 1 week of both MRI studies as markers of the airflow‐limitation severity.
Statistical Tests
Comparisons of medians were performed using the paired Wilcoxon‐test. Reproducibility was assessed using intraclass correlation coefficient (ICC). Correlations between MRI and PFT parameters were assessed using the Spearman‐test (rho correlation‐coefficient). A P‐value <0.05 was considered as significant.
Results
Defects extent on both V and Q maps showed a significant reduction after ABPA treatment (4.25 vs. 1.92 for V‐defect‐score and 5 vs. 2.75 for Q‐defect‐score). VSI_mean was significantly increased after treatment (280 vs. 167). Qualitative analyses reproducibility showed an ICC > 0.90, while the ICCs of the quantitative measurements was almost perfect (>0.99). Changes in VSI_cv and QSI_cv before and after treatment correlated inversely with changes of FEV1%p (rho = −0.68 for both).
Data Conclusion
Non‐contrast‐enhanced FD lung MRI has potential to reproducibly assess response to treatment of ABPA in CF patients and correlates with PFT obstructive parameters.
Evidence Level
4
Technical Efficacy
Stage 3</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>37265441</pmid><doi>10.1002/jmri.28844</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0251-6639</orcidid><orcidid>https://orcid.org/0000-0001-5284-8474</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1053-1807 |
| ispartof | Journal of magnetic resonance imaging, 2024-03, Vol.59 (3), p.909-919 |
| issn | 1053-1807 1522-2586 1522-2586 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_04268654v1 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | ABPA Air flow Allergic bronchopulmonary aspergillosis Allergies Allergology Aspergillosis Bioengineering Coefficient of variation Correlation coefficient Correlation coefficients Cystic fibrosis Defects Disease management Evaluation Field strength Fourier decomposition Functional magnetic resonance imaging Fungal infections Human health and pathology Image acquisition Imaging Immunology Infectious diseases Life Sciences Lungs Magnetic resonance imaging Mathematical analysis Mean Parameters Perfusion Population studies Pulmonary functions Pulmonology and respiratory tract Qualitative analysis Radiation Radiation effects Reproducibility Respiratory function Statistical analysis Statistical tests Ventilation |
| title | Non‐Contrast‐Enhanced Functional Lung MRI to Evaluate Treatment Response of Allergic Bronchopulmonary Aspergillosis in Patients With Cystic Fibrosis: A Pilot Study |
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