Differential effects of interleukin-1 and transforming growth factor beta on the synthesis of small proteoglycans by rabbit articular chondrocytes cultured in alginate beads as compared to monolayers

Small proteoglycans (PGs) are supposed to play great roles in the assembly of cartilage matrix but the influence of cytokines and growth factors on their synthesis by articular chondrocytes is largely unknown. We investigated whether IL-1 and TGFbeta1 influence the production of small leucine-rich p...

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Veröffentlicht in:	Molecular and cellular biochemistry 1999-09, Vol.199 (1-2), p.69-80
Hauptverfasser:	Demoor-Fossard, M, Boittin, M, Redini, F, Pujol, J P
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginates - metabolism Animals Cartilage, Articular - cytology Cell Culture Techniques - methods Cells, Cultured Cellular Biology Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism Chromatography, Gel Electrophoresis, Polyacrylamide Gel Glucuronic Acid Hexuronic Acids Interleukin-1 - metabolism Interleukin-1 - pharmacology Life Sciences Male Proteins - analysis Proteoglycans - biosynthesis Proteoglycans - drug effects Rabbits Sulfur Radioisotopes Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology
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