Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study
Aims To compare whether novel inflammatory and haemostatic biomarkers are more predictive of well-characterized incident acute coronary syndrome (ACS) than stable angina (SA). Methods and results We used data from the PRIME Study, a prospective cohort of 9758 asymptomatic middle-aged men recruited i...
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| Veröffentlicht in: | European heart journal 2008-08, Vol.29 (16), p.1966-1974 |
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| creator | Empana, Jean-Philippe Canoui-Poitrine, Florence Luc, Gerald Juhan-Vague, Irene Morange, Pierre Arveiler, Dominique Ferrieres, Jean Amouyel, Philippe Bingham, Annie Montaye, Michelle Ruidavets, Jean-Bernard Haas, Bernadette Evans, Alun Ducimetiere, Pierre |
| description | Aims To compare whether novel inflammatory and haemostatic biomarkers are more predictive of well-characterized incident acute coronary syndrome (ACS) than stable angina (SA). Methods and results We used data from the PRIME Study, a prospective cohort of 9758 asymptomatic middle-aged men recruited in Northern Ireland and France between 1991 and 1993. A nested case–control study was established with the baseline plasma sample of 269 incident cases and 538 matched controls. Odds ratios (ORs) for SA and ACS were estimated by conditional logistic regression analysis. After 5 years of follow-up, 107 incident SA and 162 ACS cases were validated. After adjustment for traditional risk factors, higher circulating levels of hs-CRP, ICAM1, interleukin 6 and interleukin 18 were equally predictive of SA and ACS (all P-values of OR comparison >0.05). In contrast, elevated levels of fibrinogen, von Willebrand factor, and possibly higher level of D-dimers and lower level of tissue factor pathway inhibitor were associated with ACS only. The comparison of the ORs showed a statistically significant difference for von Willebrand factor only [OR4th vs. 1st quartile = 2.99 (1.49–6.02) for ACS vs. 0.80 (0.33–1.94) for SA; Pz test = 0.02]. Conclusion This is the first population-based study suggesting that higher levels of circulating haemostatic markers and of von Willebrand factor, in particular, are significantly more predictive of incident ACS than SA. |
| doi_str_mv | 10.1093/eurheartj/ehn331 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_04245062v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/eurheartj/ehn331</oup_id><sourcerecordid>69429061</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-763c8e2e858caec80baf1b72b6b74a95665d7d0abba9f1bc14a679605362aa1c3</originalsourceid><addsrcrecordid>eNqNkU1rGzEQhkVpadyk956K6KFQyjb6WGl3cwsmiQMOLUlKQi9C0o5juWvJlbSh_vdds8aFnnoamHnmHYYHoXeUfKGk4afQxyXomFensPSc0xdoQgVjRSNL8RJNCG1EIWX9eITepLQihNSSytfoiNaS0aqiE_Q0DT5HZ_rsgsdhgX14hg4bF9Y6_oSYcA7Yeeta8BmnrE0HWPsn5_VQWqxtnwHbEIPXcYvT1rcxrOEM5yXgb7fXNxf4Lvft9gS9Wuguwdt9PUbfLy_up7Ni_vXqeno-L6woSS4qyW0NDGpRWw22JkYvqKmYkaYqdSOkFG3VEm2MboaBpaWWVSOJ4JJpTS0_Rp_G3KXu1Ca64YutCtqp2flc7XqkZKUgkj3Tgf04spsYfvWQslq7ZKHrtIfQJyWbkjVE7sAP_4Cr0Ec__KEYFYLykssBIiNkY0gpwuJwnhK1s6UOttRoa1h5v8_tzRravwt7PQPweQRCv_mfuGKkXcrw-8APHpWseCXU7PGHuuGzh6tLWqsH_geZyLH9</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>215513436</pqid></control><display><type>article</type><title>Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Empana, Jean-Philippe ; Canoui-Poitrine, Florence ; Luc, Gerald ; Juhan-Vague, Irene ; Morange, Pierre ; Arveiler, Dominique ; Ferrieres, Jean ; Amouyel, Philippe ; Bingham, Annie ; Montaye, Michelle ; Ruidavets, Jean-Bernard ; Haas, Bernadette ; Evans, Alun ; Ducimetiere, Pierre</creator><creatorcontrib>Empana, Jean-Philippe ; Canoui-Poitrine, Florence ; Luc, Gerald ; Juhan-Vague, Irene ; Morange, Pierre ; Arveiler, Dominique ; Ferrieres, Jean ; Amouyel, Philippe ; Bingham, Annie ; Montaye, Michelle ; Ruidavets, Jean-Bernard ; Haas, Bernadette ; Evans, Alun ; Ducimetiere, Pierre ; PRIME Study Group ; on behalf of the PRIME Study Group</creatorcontrib><description>Aims To compare whether novel inflammatory and haemostatic biomarkers are more predictive of well-characterized incident acute coronary syndrome (ACS) than stable angina (SA). Methods and results We used data from the PRIME Study, a prospective cohort of 9758 asymptomatic middle-aged men recruited in Northern Ireland and France between 1991 and 1993. A nested case–control study was established with the baseline plasma sample of 269 incident cases and 538 matched controls. Odds ratios (ORs) for SA and ACS were estimated by conditional logistic regression analysis. After 5 years of follow-up, 107 incident SA and 162 ACS cases were validated. After adjustment for traditional risk factors, higher circulating levels of hs-CRP, ICAM1, interleukin 6 and interleukin 18 were equally predictive of SA and ACS (all P-values of OR comparison >0.05). In contrast, elevated levels of fibrinogen, von Willebrand factor, and possibly higher level of D-dimers and lower level of tissue factor pathway inhibitor were associated with ACS only. The comparison of the ORs showed a statistically significant difference for von Willebrand factor only [OR4th vs. 1st quartile = 2.99 (1.49–6.02) for ACS vs. 0.80 (0.33–1.94) for SA; Pz test = 0.02]. Conclusion This is the first population-based study suggesting that higher levels of circulating haemostatic markers and of von Willebrand factor, in particular, are significantly more predictive of incident ACS than SA.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehn331</identifier><identifier>PMID: 18621771</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Acute coronary syndrome ; Acute Coronary Syndrome - blood ; Acute Coronary Syndrome - diagnosis ; Acute Coronary Syndrome - etiology ; Angina pectoris ; Angina Pectoris - blood ; Angina Pectoris - diagnosis ; Angina Pectoris - etiology ; Atherothrombosis ; Biomarkers ; Biomarkers - analysis ; Biomarkers - blood ; Epidemiologic Methods ; Epidemiology ; Fibrin Fibrinogen Degradation Products - analysis ; Fibrinogen - analysis ; France ; Humans ; Life Sciences ; Lipoproteins - blood ; Male ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - diagnosis ; Myocardial Infarction - etiology ; Northern Ireland ; von Willebrand Factor - analysis</subject><ispartof>European heart journal, 2008-08, Vol.29 (16), p.1966-1974</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org 2008</rights><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-763c8e2e858caec80baf1b72b6b74a95665d7d0abba9f1bc14a679605362aa1c3</citedby><cites>FETCH-LOGICAL-c540t-763c8e2e858caec80baf1b72b6b74a95665d7d0abba9f1bc14a679605362aa1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18621771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04245062$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Empana, Jean-Philippe</creatorcontrib><creatorcontrib>Canoui-Poitrine, Florence</creatorcontrib><creatorcontrib>Luc, Gerald</creatorcontrib><creatorcontrib>Juhan-Vague, Irene</creatorcontrib><creatorcontrib>Morange, Pierre</creatorcontrib><creatorcontrib>Arveiler, Dominique</creatorcontrib><creatorcontrib>Ferrieres, Jean</creatorcontrib><creatorcontrib>Amouyel, Philippe</creatorcontrib><creatorcontrib>Bingham, Annie</creatorcontrib><creatorcontrib>Montaye, Michelle</creatorcontrib><creatorcontrib>Ruidavets, Jean-Bernard</creatorcontrib><creatorcontrib>Haas, Bernadette</creatorcontrib><creatorcontrib>Evans, Alun</creatorcontrib><creatorcontrib>Ducimetiere, Pierre</creatorcontrib><creatorcontrib>PRIME Study Group</creatorcontrib><creatorcontrib>on behalf of the PRIME Study Group</creatorcontrib><title>Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Aims To compare whether novel inflammatory and haemostatic biomarkers are more predictive of well-characterized incident acute coronary syndrome (ACS) than stable angina (SA). Methods and results We used data from the PRIME Study, a prospective cohort of 9758 asymptomatic middle-aged men recruited in Northern Ireland and France between 1991 and 1993. A nested case–control study was established with the baseline plasma sample of 269 incident cases and 538 matched controls. Odds ratios (ORs) for SA and ACS were estimated by conditional logistic regression analysis. After 5 years of follow-up, 107 incident SA and 162 ACS cases were validated. After adjustment for traditional risk factors, higher circulating levels of hs-CRP, ICAM1, interleukin 6 and interleukin 18 were equally predictive of SA and ACS (all P-values of OR comparison >0.05). In contrast, elevated levels of fibrinogen, von Willebrand factor, and possibly higher level of D-dimers and lower level of tissue factor pathway inhibitor were associated with ACS only. The comparison of the ORs showed a statistically significant difference for von Willebrand factor only [OR4th vs. 1st quartile = 2.99 (1.49–6.02) for ACS vs. 0.80 (0.33–1.94) for SA; Pz test = 0.02]. Conclusion This is the first population-based study suggesting that higher levels of circulating haemostatic markers and of von Willebrand factor, in particular, are significantly more predictive of incident ACS than SA.</description><subject>Acute coronary syndrome</subject><subject>Acute Coronary Syndrome - blood</subject><subject>Acute Coronary Syndrome - diagnosis</subject><subject>Acute Coronary Syndrome - etiology</subject><subject>Angina pectoris</subject><subject>Angina Pectoris - blood</subject><subject>Angina Pectoris - diagnosis</subject><subject>Angina Pectoris - etiology</subject><subject>Atherothrombosis</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - blood</subject><subject>Epidemiologic Methods</subject><subject>Epidemiology</subject><subject>Fibrin Fibrinogen Degradation Products - analysis</subject><subject>Fibrinogen - analysis</subject><subject>France</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lipoproteins - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - etiology</subject><subject>Northern Ireland</subject><subject>von Willebrand Factor - analysis</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1rGzEQhkVpadyk956K6KFQyjb6WGl3cwsmiQMOLUlKQi9C0o5juWvJlbSh_vdds8aFnnoamHnmHYYHoXeUfKGk4afQxyXomFensPSc0xdoQgVjRSNL8RJNCG1EIWX9eITepLQihNSSytfoiNaS0aqiE_Q0DT5HZ_rsgsdhgX14hg4bF9Y6_oSYcA7Yeeta8BmnrE0HWPsn5_VQWqxtnwHbEIPXcYvT1rcxrOEM5yXgb7fXNxf4Lvft9gS9Wuguwdt9PUbfLy_up7Ni_vXqeno-L6woSS4qyW0NDGpRWw22JkYvqKmYkaYqdSOkFG3VEm2MboaBpaWWVSOJ4JJpTS0_Rp_G3KXu1Ca64YutCtqp2flc7XqkZKUgkj3Tgf04spsYfvWQslq7ZKHrtIfQJyWbkjVE7sAP_4Cr0Ec__KEYFYLykssBIiNkY0gpwuJwnhK1s6UOttRoa1h5v8_tzRravwt7PQPweQRCv_mfuGKkXcrw-8APHpWseCXU7PGHuuGzh6tLWqsH_geZyLH9</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Empana, Jean-Philippe</creator><creator>Canoui-Poitrine, Florence</creator><creator>Luc, Gerald</creator><creator>Juhan-Vague, Irene</creator><creator>Morange, Pierre</creator><creator>Arveiler, Dominique</creator><creator>Ferrieres, Jean</creator><creator>Amouyel, Philippe</creator><creator>Bingham, Annie</creator><creator>Montaye, Michelle</creator><creator>Ruidavets, Jean-Bernard</creator><creator>Haas, Bernadette</creator><creator>Evans, Alun</creator><creator>Ducimetiere, Pierre</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><general>Oxford University Press (OUP)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20080801</creationdate><title>Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study</title><author>Empana, Jean-Philippe ; Canoui-Poitrine, Florence ; Luc, Gerald ; Juhan-Vague, Irene ; Morange, Pierre ; Arveiler, Dominique ; Ferrieres, Jean ; Amouyel, Philippe ; Bingham, Annie ; Montaye, Michelle ; Ruidavets, Jean-Bernard ; Haas, Bernadette ; Evans, Alun ; Ducimetiere, Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-763c8e2e858caec80baf1b72b6b74a95665d7d0abba9f1bc14a679605362aa1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acute coronary syndrome</topic><topic>Acute Coronary Syndrome - blood</topic><topic>Acute Coronary Syndrome - diagnosis</topic><topic>Acute Coronary Syndrome - etiology</topic><topic>Angina pectoris</topic><topic>Angina Pectoris - blood</topic><topic>Angina Pectoris - diagnosis</topic><topic>Angina Pectoris - etiology</topic><topic>Atherothrombosis</topic><topic>Biomarkers</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - blood</topic><topic>Epidemiologic Methods</topic><topic>Epidemiology</topic><topic>Fibrin Fibrinogen Degradation Products - analysis</topic><topic>Fibrinogen - analysis</topic><topic>France</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Lipoproteins - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - etiology</topic><topic>Northern Ireland</topic><topic>von Willebrand Factor - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Empana, Jean-Philippe</creatorcontrib><creatorcontrib>Canoui-Poitrine, Florence</creatorcontrib><creatorcontrib>Luc, Gerald</creatorcontrib><creatorcontrib>Juhan-Vague, Irene</creatorcontrib><creatorcontrib>Morange, Pierre</creatorcontrib><creatorcontrib>Arveiler, Dominique</creatorcontrib><creatorcontrib>Ferrieres, Jean</creatorcontrib><creatorcontrib>Amouyel, Philippe</creatorcontrib><creatorcontrib>Bingham, Annie</creatorcontrib><creatorcontrib>Montaye, Michelle</creatorcontrib><creatorcontrib>Ruidavets, Jean-Bernard</creatorcontrib><creatorcontrib>Haas, Bernadette</creatorcontrib><creatorcontrib>Evans, Alun</creatorcontrib><creatorcontrib>Ducimetiere, Pierre</creatorcontrib><creatorcontrib>PRIME Study Group</creatorcontrib><creatorcontrib>on behalf of the PRIME Study Group</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Empana, Jean-Philippe</au><au>Canoui-Poitrine, Florence</au><au>Luc, Gerald</au><au>Juhan-Vague, Irene</au><au>Morange, Pierre</au><au>Arveiler, Dominique</au><au>Ferrieres, Jean</au><au>Amouyel, Philippe</au><au>Bingham, Annie</au><au>Montaye, Michelle</au><au>Ruidavets, Jean-Bernard</au><au>Haas, Bernadette</au><au>Evans, Alun</au><au>Ducimetiere, Pierre</au><aucorp>PRIME Study Group</aucorp><aucorp>on behalf of the PRIME Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>29</volume><issue>16</issue><spage>1966</spage><epage>1974</epage><pages>1966-1974</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Aims To compare whether novel inflammatory and haemostatic biomarkers are more predictive of well-characterized incident acute coronary syndrome (ACS) than stable angina (SA). Methods and results We used data from the PRIME Study, a prospective cohort of 9758 asymptomatic middle-aged men recruited in Northern Ireland and France between 1991 and 1993. A nested case–control study was established with the baseline plasma sample of 269 incident cases and 538 matched controls. Odds ratios (ORs) for SA and ACS were estimated by conditional logistic regression analysis. After 5 years of follow-up, 107 incident SA and 162 ACS cases were validated. After adjustment for traditional risk factors, higher circulating levels of hs-CRP, ICAM1, interleukin 6 and interleukin 18 were equally predictive of SA and ACS (all P-values of OR comparison >0.05). In contrast, elevated levels of fibrinogen, von Willebrand factor, and possibly higher level of D-dimers and lower level of tissue factor pathway inhibitor were associated with ACS only. The comparison of the ORs showed a statistically significant difference for von Willebrand factor only [OR4th vs. 1st quartile = 2.99 (1.49–6.02) for ACS vs. 0.80 (0.33–1.94) for SA; Pz test = 0.02]. Conclusion This is the first population-based study suggesting that higher levels of circulating haemostatic markers and of von Willebrand factor, in particular, are significantly more predictive of incident ACS than SA.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>18621771</pmid><doi>10.1093/eurheartj/ehn331</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acute coronary syndrome Acute Coronary Syndrome - blood Acute Coronary Syndrome - diagnosis Acute Coronary Syndrome - etiology Angina pectoris Angina Pectoris - blood Angina Pectoris - diagnosis Angina Pectoris - etiology Atherothrombosis Biomarkers Biomarkers - analysis Biomarkers - blood Epidemiologic Methods Epidemiology Fibrin Fibrinogen Degradation Products - analysis Fibrinogen - analysis France Humans Life Sciences Lipoproteins - blood Male Middle Aged Myocardial Infarction - blood Myocardial Infarction - diagnosis Myocardial Infarction - etiology Northern Ireland von Willebrand Factor - analysis |
| title | Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study |
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