Studies on the Total Synthesis of Lactonamycin:  Synthesis of the CDEF Ring System

A concise and efficient synthesis of the tetracyclic CDEF ring system of lactonamycin (1) is described. The key step involved the Lewis acid mediated, intramolecular Friedel−Crafts acylation of carboxylic acid 6 to produce the tetracyclic CDEF core structure of target 1. The synthesis of 6 was carri...

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Veröffentlicht in:	Journal of organic chemistry 2006-10, Vol.71 (21), p.8151-8158
Hauptverfasser:	Wehlan, Hermut, Jezek, Eva, Lebrasseur, Nathalie, Pavé, Grégoire, Roulland, Emmanuel, White, Andrew J. P, Burrows, Jeremy N, Barrett, Anthony G. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Chemistry Exact sciences and technology Indoles - chemical synthesis Naphthoquinones - chemical synthesis Organic chemistry
Online-Zugang:	Volltext
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