Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults
Pituitary stalk interruption syndrome (PSIS) is rare in the pediatric population. It combines ectopic posterior pituitary stalk interruption and anterior pituitary hypoplasia with hormonal deficiencies. The phenotype is highly heterogeneous and obesity/overweight seems to be underreported in the lit...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2023-02, Vol.108 (2), p.323-330 |
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| creator | Nannette, Gaëlle Bar, Céline Diene, Gwenaëlle Pienkowski, Catherine Oliver-Petit, Isabelle Jouret, Béatrice Cartault, Audrey Porquet-Bordes, Valérie Salles, Jean-Pierre Grunenwald, Solange Edouard, Thomas Molinas, Catherine Tauber, Maithé |
| description | Pituitary stalk interruption syndrome (PSIS) is rare in the pediatric population. It combines ectopic posterior pituitary stalk interruption and anterior pituitary hypoplasia with hormonal deficiencies. The phenotype is highly heterogeneous and obesity/overweight seems to be underreported in the literature.
To identify patients with PSIS and obesity or overweight, describe their phenotype, and compare them with patients with PSIS without overweight/obesity.
Sixty-nine children and young adults with PSIS in a Toulouse cohort from 1984 to 2019 were studied. We identified 25 obese or overweight patients (OB-OW group), and 44 were nonobese/overweight (NO group). Then the groups were compared.
All cases were sporadic. The sex ratio was 1.6. The main reason for consultation in both groups was growth retardation (61% in OB-OW group, 77% in NO group). History of neonatal hypoglycemia was more common in the OB-OW than in the NO group (57% vs 14%, P = .0008), along with extrapituitary malformations (64% vs 20%, P < 0001). The incidence of caesarean section was higher in the OB-OW group (52%) than in the NO group (23%), although not significant (P = .07).
Patients with PSIS who are obese/overweight display interesting phenotypic differences that suggest hypothalamic defects. Studies are needed that include additional information on hormonal levels, particularly regarding oxytocin and ghrelin. |
| doi_str_mv | 10.1210/clinem/dgac583 |
| format | Article |
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To identify patients with PSIS and obesity or overweight, describe their phenotype, and compare them with patients with PSIS without overweight/obesity.
Sixty-nine children and young adults with PSIS in a Toulouse cohort from 1984 to 2019 were studied. We identified 25 obese or overweight patients (OB-OW group), and 44 were nonobese/overweight (NO group). Then the groups were compared.
All cases were sporadic. The sex ratio was 1.6. The main reason for consultation in both groups was growth retardation (61% in OB-OW group, 77% in NO group). History of neonatal hypoglycemia was more common in the OB-OW than in the NO group (57% vs 14%, P = .0008), along with extrapituitary malformations (64% vs 20%, P < 0001). The incidence of caesarean section was higher in the OB-OW group (52%) than in the NO group (23%), although not significant (P = .07).
Patients with PSIS who are obese/overweight display interesting phenotypic differences that suggest hypothalamic defects. Studies are needed that include additional information on hormonal levels, particularly regarding oxytocin and ghrelin.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/clinem/dgac583</identifier><identifier>PMID: 36201475</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Cesarean Section ; Child ; Endocrinology and metabolism ; Female ; Human health and pathology ; Humans ; Life Sciences ; Obesity - complications ; Obesity - epidemiology ; Obesity in children ; Overweight - complications ; Overweight - epidemiology ; Pediatrics ; Pituitary Diseases - complications ; Pituitary Diseases - epidemiology ; Pituitary Diseases - genetics ; Pituitary Gland - abnormalities ; Pregnancy ; Young Adult</subject><ispartof>The journal of clinical endocrinology and metabolism, 2023-02, Vol.108 (2), p.323-330</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2023 Oxford University Press</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-2f15d1d0c073bc5aa7aaf68489850de893639dd7ebe429bef523c92a4f999f623</citedby><cites>FETCH-LOGICAL-c436t-2f15d1d0c073bc5aa7aaf68489850de893639dd7ebe429bef523c92a4f999f623</cites><orcidid>0000-0002-0363-7862 ; 0000-0002-9222-5009 ; 0009-0003-8970-0088 ; 0000-0002-0941-8951</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36201475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04233001$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Nannette, Gaëlle</creatorcontrib><creatorcontrib>Bar, Céline</creatorcontrib><creatorcontrib>Diene, Gwenaëlle</creatorcontrib><creatorcontrib>Pienkowski, Catherine</creatorcontrib><creatorcontrib>Oliver-Petit, Isabelle</creatorcontrib><creatorcontrib>Jouret, Béatrice</creatorcontrib><creatorcontrib>Cartault, Audrey</creatorcontrib><creatorcontrib>Porquet-Bordes, Valérie</creatorcontrib><creatorcontrib>Salles, Jean-Pierre</creatorcontrib><creatorcontrib>Grunenwald, Solange</creatorcontrib><creatorcontrib>Edouard, Thomas</creatorcontrib><creatorcontrib>Molinas, Catherine</creatorcontrib><creatorcontrib>Tauber, Maithé</creatorcontrib><title>Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Pituitary stalk interruption syndrome (PSIS) is rare in the pediatric population. It combines ectopic posterior pituitary stalk interruption and anterior pituitary hypoplasia with hormonal deficiencies. The phenotype is highly heterogeneous and obesity/overweight seems to be underreported in the literature.
To identify patients with PSIS and obesity or overweight, describe their phenotype, and compare them with patients with PSIS without overweight/obesity.
Sixty-nine children and young adults with PSIS in a Toulouse cohort from 1984 to 2019 were studied. We identified 25 obese or overweight patients (OB-OW group), and 44 were nonobese/overweight (NO group). Then the groups were compared.
All cases were sporadic. The sex ratio was 1.6. The main reason for consultation in both groups was growth retardation (61% in OB-OW group, 77% in NO group). History of neonatal hypoglycemia was more common in the OB-OW than in the NO group (57% vs 14%, P = .0008), along with extrapituitary malformations (64% vs 20%, P < 0001). The incidence of caesarean section was higher in the OB-OW group (52%) than in the NO group (23%), although not significant (P = .07).
Patients with PSIS who are obese/overweight display interesting phenotypic differences that suggest hypothalamic defects. Studies are needed that include additional information on hormonal levels, particularly regarding oxytocin and ghrelin.</description><subject>Cesarean Section</subject><subject>Child</subject><subject>Endocrinology and metabolism</subject><subject>Female</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Obesity in children</subject><subject>Overweight - complications</subject><subject>Overweight - epidemiology</subject><subject>Pediatrics</subject><subject>Pituitary Diseases - complications</subject><subject>Pituitary Diseases - epidemiology</subject><subject>Pituitary Diseases - genetics</subject><subject>Pituitary Gland - abnormalities</subject><subject>Pregnancy</subject><subject>Young Adult</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1rGzEQxUVpaNy01x7LQi8tZBN9rFarozFtEjC4kBYSehBaadZWu6t1JW2K__vKsZNTmMMMw-8Nb3gIfSD4glCCL03vPAyXdq0Nb9grNCOy4qUgUrxGM4wpKaWgd6fobYy_MSZVxdkbdMpqmmfBZ-jXqoXo0u68WD1A-AduvUnnhfa2-O7S5JIOu-I26f5PceMThDBtkxt9cbvzNowDFM4Xi43rbQD_qLofJ78u5nbqU3yHTjrdR3h_7Gfo57evPxbX5XJ1dbOYL0tTsTqVtCPcEosNFqw1XGuhdVc3VSMbji00ktVMWiughYrKFjpOmZFUV52UsqspO0NfDnc3ulfb4IZsWo3aqev5Uu13uKKM5e8fSGY_H9htGP9OEJMaXDTQ99rDOEVFBaWM5OIZ_XRA17oH5Xw3pqDNHldzIWrMayJEpi5eoHJZGJwZPXQu718SmDDGGKB7tkyw2meqDpmqY6ZZ8PFoeWoHsM_4U4jsP4EmnUk</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Nannette, Gaëlle</creator><creator>Bar, Céline</creator><creator>Diene, Gwenaëlle</creator><creator>Pienkowski, Catherine</creator><creator>Oliver-Petit, Isabelle</creator><creator>Jouret, Béatrice</creator><creator>Cartault, Audrey</creator><creator>Porquet-Bordes, Valérie</creator><creator>Salles, Jean-Pierre</creator><creator>Grunenwald, Solange</creator><creator>Edouard, Thomas</creator><creator>Molinas, Catherine</creator><creator>Tauber, Maithé</creator><general>Oxford University Press</general><general>Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-0363-7862</orcidid><orcidid>https://orcid.org/0000-0002-9222-5009</orcidid><orcidid>https://orcid.org/0009-0003-8970-0088</orcidid><orcidid>https://orcid.org/0000-0002-0941-8951</orcidid></search><sort><creationdate>20230201</creationdate><title>Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults</title><author>Nannette, Gaëlle ; Bar, Céline ; Diene, Gwenaëlle ; Pienkowski, Catherine ; Oliver-Petit, Isabelle ; Jouret, Béatrice ; Cartault, Audrey ; Porquet-Bordes, Valérie ; Salles, Jean-Pierre ; Grunenwald, Solange ; Edouard, Thomas ; Molinas, Catherine ; Tauber, Maithé</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-2f15d1d0c073bc5aa7aaf68489850de893639dd7ebe429bef523c92a4f999f623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cesarean Section</topic><topic>Child</topic><topic>Endocrinology and metabolism</topic><topic>Female</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Obesity in children</topic><topic>Overweight - complications</topic><topic>Overweight - epidemiology</topic><topic>Pediatrics</topic><topic>Pituitary Diseases - complications</topic><topic>Pituitary Diseases - epidemiology</topic><topic>Pituitary Diseases - genetics</topic><topic>Pituitary Gland - abnormalities</topic><topic>Pregnancy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nannette, Gaëlle</creatorcontrib><creatorcontrib>Bar, Céline</creatorcontrib><creatorcontrib>Diene, Gwenaëlle</creatorcontrib><creatorcontrib>Pienkowski, Catherine</creatorcontrib><creatorcontrib>Oliver-Petit, Isabelle</creatorcontrib><creatorcontrib>Jouret, Béatrice</creatorcontrib><creatorcontrib>Cartault, Audrey</creatorcontrib><creatorcontrib>Porquet-Bordes, Valérie</creatorcontrib><creatorcontrib>Salles, Jean-Pierre</creatorcontrib><creatorcontrib>Grunenwald, Solange</creatorcontrib><creatorcontrib>Edouard, Thomas</creatorcontrib><creatorcontrib>Molinas, Catherine</creatorcontrib><creatorcontrib>Tauber, Maithé</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nannette, Gaëlle</au><au>Bar, Céline</au><au>Diene, Gwenaëlle</au><au>Pienkowski, Catherine</au><au>Oliver-Petit, Isabelle</au><au>Jouret, Béatrice</au><au>Cartault, Audrey</au><au>Porquet-Bordes, Valérie</au><au>Salles, Jean-Pierre</au><au>Grunenwald, Solange</au><au>Edouard, Thomas</au><au>Molinas, Catherine</au><au>Tauber, Maithé</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>108</volume><issue>2</issue><spage>323</spage><epage>330</epage><pages>323-330</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Pituitary stalk interruption syndrome (PSIS) is rare in the pediatric population. It combines ectopic posterior pituitary stalk interruption and anterior pituitary hypoplasia with hormonal deficiencies. The phenotype is highly heterogeneous and obesity/overweight seems to be underreported in the literature.
To identify patients with PSIS and obesity or overweight, describe their phenotype, and compare them with patients with PSIS without overweight/obesity.
Sixty-nine children and young adults with PSIS in a Toulouse cohort from 1984 to 2019 were studied. We identified 25 obese or overweight patients (OB-OW group), and 44 were nonobese/overweight (NO group). Then the groups were compared.
All cases were sporadic. The sex ratio was 1.6. The main reason for consultation in both groups was growth retardation (61% in OB-OW group, 77% in NO group). History of neonatal hypoglycemia was more common in the OB-OW than in the NO group (57% vs 14%, P = .0008), along with extrapituitary malformations (64% vs 20%, P < 0001). The incidence of caesarean section was higher in the OB-OW group (52%) than in the NO group (23%), although not significant (P = .07).
Patients with PSIS who are obese/overweight display interesting phenotypic differences that suggest hypothalamic defects. Studies are needed that include additional information on hormonal levels, particularly regarding oxytocin and ghrelin.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>36201475</pmid><doi>10.1210/clinem/dgac583</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0363-7862</orcidid><orcidid>https://orcid.org/0000-0002-9222-5009</orcidid><orcidid>https://orcid.org/0009-0003-8970-0088</orcidid><orcidid>https://orcid.org/0000-0002-0941-8951</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Cesarean Section Child Endocrinology and metabolism Female Human health and pathology Humans Life Sciences Obesity - complications Obesity - epidemiology Obesity in children Overweight - complications Overweight - epidemiology Pediatrics Pituitary Diseases - complications Pituitary Diseases - epidemiology Pituitary Diseases - genetics Pituitary Gland - abnormalities Pregnancy Young Adult |
| title | Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults |
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