Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice

The proposed feedback between angiotensin II AT 2 and AT 1 receptors prompted us to study AT 1 receptor expression in kidneys of male AT 2 receptor-gene disrupted mice ( agtr2 −/y). In wild-type ( agtr2 +/y) mice, AT 1 receptor binding and mRNA is abundant in glomeruli, and AT 1 receptor binding is...

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Veröffentlicht in:American journal of physiology. Renal physiology 2001-01, Vol.280 (1), p.F71-F78
Hauptverfasser: Saavedra, Juan M., Häuser, Walter, Ciuffo, Gladys, Egidy, Giorgia, Hoe, Kwang-Lae, Jöhren, Olaf, Sembonmatsu, Takaaki, Inagami, Tadashi, Armando, Inés
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Sprache:eng
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