Selective attachment of a microtubule interacting peptide to plasmid DNA via a triplex forming oligonucleotide for transfection improvement

In nonviral gene therapy approaches, the linkage of signal molecules to plasmid DNA (pDNA) is of interest for guiding its delivery to the nucleus. Here, we report its linkage to a peptide (P 79–98 ) mediating migration on microtubules by using a triplex-forming oligonucleotide (TFO). pDNA of 5 kbp a...

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Veröffentlicht in:	Gene therapy 2023-04, Vol.30 (3-4), p.271-277
Hauptverfasser:	Girardin, Caroline, Maze, Delphine, Gonçalves, Cristine, Le Guen, Yann Thierry, Pluchon, Kevin, Pichon, Chantal, Montier, Tristan, Midoux, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 42 42/41 59/5 631/1647/2300/1851 631/61/201 Animals Biomedical and Life Sciences Biomedicine Cell Biology DNA - genetics Gene Expression Gene Therapy Human Genetics Life Sciences Mice Microtubules Microtubules - metabolism Nanotechnology Oligonucleotides Oligonucleotides - chemistry Oligonucleotides - genetics Peptides Peptides - genetics Plasmids - genetics Transfection
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