Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study
Background This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years. Methods We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2021-11, Vol.76 (11), p.e361-e369 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Lu, Wan-Hsuan de Souto Barreto, Philipe Rolland, Yves Bouyahia, Ali Fischer, Clara Mangin, Jean-François Giudici, Kelly V Vellas, Bruno |
| description | Background
This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years.
Methods
We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail at baseline (according to Fried’s criteria) and who had at least 1 post-baseline measurement of frailty. Participants who progressed to frailty during the 5-year follow-up were categorized as “incident frailty” and those who remained non-frail were categorized as “without frailty.” The differences of baseline biochemical factors (25-hydroxyvitamin D, homocysteine, omega-3 index, C-reactive protein), other biological markers (Apolipoprotein E genotypes, amyloid-β deposits), and neuroimaging data (gray matter volume, hippocampal volume, white matter hyperintensities) were compared between groups. Cox proportional hazard model was used to evaluate the associations between biomarkers and incident frailty.
Results
A total of 195 participants (14.0%) became frail over 5 years. Although 25-hydroxyvitamin D deficiency, homocysteine levels, low-grade inflammation (persistently increased C-reactive protein 3–10 mg/L), gray matter, and hippocampal volume were significantly associated with incident frailty in unadjusted models, these associations disappeared after adjustment for age, sex, and other confounders. Omega-3 index was the sole marker that presented a trend of association with incident frailty (hazard ratio: 0.92; 95% confidence interval: 0.83–1.01; p = .082).
Conclusions
This study failed to identify biomarkers able to predict frailty incidence in community-dwelling older adults for a period of 5 years. Further longitudinal research with multiple measurements of biomarkers and frailty is needed to evaluate the long-term relationships between changes in biomarkers levels and frailty evolution. |
| doi_str_mv | 10.1093/gerona/glaa296 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_04158260v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/gerona/glaa296</oup_id><sourcerecordid>2465442438</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-aca3a9f75550a3e90b8719b8afe52ad1c2d2cebaf0c44ae2967d77a4219d6b1c3</originalsourceid><addsrcrecordid>eNqFkc1v1DAQxSMEoqVw5YgscYFDWn_E-eAWKkorbWmlFglO1sSepC7eeLETpNz5w_GyS5G44MvY1m-e5s3LspeMHjPaiJMBgx_hZHAAvCkfZYesknUuhfzyON1p1eSS0vIgexbjPd0eyZ9mB0LwohSiPsx-vrfe-cFqcARGQz7hHLxdw2DHgVxC-IYhEojkOqCxevLp5Xsi868IgVyM2hocJ3IWwLppIXYkV85gIK2Z3RTfkZbcoPajgbCQdgS3RPtbYLpDctle35KbaTbL8-xJDy7ii309yj6ffbg9Pc9XVx8vTttVrkXDphw0CGj6SkpJQWBDu7piTVdDj5KDYZobrrGDnuqiAEz7qExVQcFZY8qOaXGUvd3p3oFTm5BshkV5sOq8XantHy2YrHlJf7DEvtmxm-C_zxgntbZRo3Mwop-jSguURcELUSf09T_ovZ9DcpsoWVecyobxRB3vKB18jAH7hwkYVdss1S5Ltc8yNbzay87dGs0D_ie8v3b8vPmf2C-p4Kn4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2587205912</pqid></control><display><type>article</type><title>Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>Sociological Abstracts</source><creator>Lu, Wan-Hsuan ; de Souto Barreto, Philipe ; Rolland, Yves ; Bouyahia, Ali ; Fischer, Clara ; Mangin, Jean-François ; Giudici, Kelly V ; Vellas, Bruno</creator><creatorcontrib>Lu, Wan-Hsuan ; de Souto Barreto, Philipe ; Rolland, Yves ; Bouyahia, Ali ; Fischer, Clara ; Mangin, Jean-François ; Giudici, Kelly V ; Vellas, Bruno ; MAPT/DSA Group</creatorcontrib><description>Background
This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years.
Methods
We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail at baseline (according to Fried’s criteria) and who had at least 1 post-baseline measurement of frailty. Participants who progressed to frailty during the 5-year follow-up were categorized as “incident frailty” and those who remained non-frail were categorized as “without frailty.” The differences of baseline biochemical factors (25-hydroxyvitamin D, homocysteine, omega-3 index, C-reactive protein), other biological markers (Apolipoprotein E genotypes, amyloid-β deposits), and neuroimaging data (gray matter volume, hippocampal volume, white matter hyperintensities) were compared between groups. Cox proportional hazard model was used to evaluate the associations between biomarkers and incident frailty.
Results
A total of 195 participants (14.0%) became frail over 5 years. Although 25-hydroxyvitamin D deficiency, homocysteine levels, low-grade inflammation (persistently increased C-reactive protein 3–10 mg/L), gray matter, and hippocampal volume were significantly associated with incident frailty in unadjusted models, these associations disappeared after adjustment for age, sex, and other confounders. Omega-3 index was the sole marker that presented a trend of association with incident frailty (hazard ratio: 0.92; 95% confidence interval: 0.83–1.01; p = .082).
Conclusions
This study failed to identify biomarkers able to predict frailty incidence in community-dwelling older adults for a period of 5 years. Further longitudinal research with multiple measurements of biomarkers and frailty is needed to evaluate the long-term relationships between changes in biomarkers levels and frailty evolution.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glaa296</identifier><identifier>PMID: 33246338</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>25-Hydroxyvitamin D ; Aged ; Aged, 80 and over ; Alzheimer Disease ; Alzheimer's disease ; Apolipoprotein E ; Biomarkers ; C-Reactive Protein ; Fatty Acids, Omega-3 ; Frail Elderly ; Frailty ; Genotypes ; Gerontology ; Hippocampus ; Homocysteine ; Humans ; Indexes ; Life Sciences ; Neuroimaging ; Older people ; Proteins ; Substantia alba ; Substantia grisea ; β-Amyloid</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2021-11, Vol.76 (11), p.e361-e369</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press Nov 2021</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-aca3a9f75550a3e90b8719b8afe52ad1c2d2cebaf0c44ae2967d77a4219d6b1c3</citedby><cites>FETCH-LOGICAL-c391t-aca3a9f75550a3e90b8719b8afe52ad1c2d2cebaf0c44ae2967d77a4219d6b1c3</cites><orcidid>0000-0001-7824-4214 ; 0000-0003-4107-8309 ; 0000-0002-1142-770X ; 0009-0005-9607-9722 ; 0000-0002-5802-3518 ; 0000-0002-1374-1620 ; 0000-0002-7678-5065 ; 0000-0002-1157-0215 ; 0000-0002-1671-824X ; 0009-0003-9486-9144 ; 0000-0001-8690-8615 ; 0000-0001-7182-9914 ; 0000-0002-8860-425X ; 0000-0003-0046-2478 ; 0000-0002-1185-3960</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902,33751</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33246338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://ut3-toulouseinp.hal.science/hal-04158260$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Wan-Hsuan</creatorcontrib><creatorcontrib>de Souto Barreto, Philipe</creatorcontrib><creatorcontrib>Rolland, Yves</creatorcontrib><creatorcontrib>Bouyahia, Ali</creatorcontrib><creatorcontrib>Fischer, Clara</creatorcontrib><creatorcontrib>Mangin, Jean-François</creatorcontrib><creatorcontrib>Giudici, Kelly V</creatorcontrib><creatorcontrib>Vellas, Bruno</creatorcontrib><creatorcontrib>MAPT/DSA Group</creatorcontrib><title>Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Background
This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years.
Methods
We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail at baseline (according to Fried’s criteria) and who had at least 1 post-baseline measurement of frailty. Participants who progressed to frailty during the 5-year follow-up were categorized as “incident frailty” and those who remained non-frail were categorized as “without frailty.” The differences of baseline biochemical factors (25-hydroxyvitamin D, homocysteine, omega-3 index, C-reactive protein), other biological markers (Apolipoprotein E genotypes, amyloid-β deposits), and neuroimaging data (gray matter volume, hippocampal volume, white matter hyperintensities) were compared between groups. Cox proportional hazard model was used to evaluate the associations between biomarkers and incident frailty.
Results
A total of 195 participants (14.0%) became frail over 5 years. Although 25-hydroxyvitamin D deficiency, homocysteine levels, low-grade inflammation (persistently increased C-reactive protein 3–10 mg/L), gray matter, and hippocampal volume were significantly associated with incident frailty in unadjusted models, these associations disappeared after adjustment for age, sex, and other confounders. Omega-3 index was the sole marker that presented a trend of association with incident frailty (hazard ratio: 0.92; 95% confidence interval: 0.83–1.01; p = .082).
Conclusions
This study failed to identify biomarkers able to predict frailty incidence in community-dwelling older adults for a period of 5 years. Further longitudinal research with multiple measurements of biomarkers and frailty is needed to evaluate the long-term relationships between changes in biomarkers levels and frailty evolution.</description><subject>25-Hydroxyvitamin D</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease</subject><subject>Alzheimer's disease</subject><subject>Apolipoprotein E</subject><subject>Biomarkers</subject><subject>C-Reactive Protein</subject><subject>Fatty Acids, Omega-3</subject><subject>Frail Elderly</subject><subject>Frailty</subject><subject>Genotypes</subject><subject>Gerontology</subject><subject>Hippocampus</subject><subject>Homocysteine</subject><subject>Humans</subject><subject>Indexes</subject><subject>Life Sciences</subject><subject>Neuroimaging</subject><subject>Older people</subject><subject>Proteins</subject><subject>Substantia alba</subject><subject>Substantia grisea</subject><subject>β-Amyloid</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BHHNA</sourceid><recordid>eNqFkc1v1DAQxSMEoqVw5YgscYFDWn_E-eAWKkorbWmlFglO1sSepC7eeLETpNz5w_GyS5G44MvY1m-e5s3LspeMHjPaiJMBgx_hZHAAvCkfZYesknUuhfzyON1p1eSS0vIgexbjPd0eyZ9mB0LwohSiPsx-vrfe-cFqcARGQz7hHLxdw2DHgVxC-IYhEojkOqCxevLp5Xsi868IgVyM2hocJ3IWwLppIXYkV85gIK2Z3RTfkZbcoPajgbCQdgS3RPtbYLpDctle35KbaTbL8-xJDy7ii309yj6ffbg9Pc9XVx8vTttVrkXDphw0CGj6SkpJQWBDu7piTVdDj5KDYZobrrGDnuqiAEz7qExVQcFZY8qOaXGUvd3p3oFTm5BshkV5sOq8XantHy2YrHlJf7DEvtmxm-C_zxgntbZRo3Mwop-jSguURcELUSf09T_ovZ9DcpsoWVecyobxRB3vKB18jAH7hwkYVdss1S5Ltc8yNbzay87dGs0D_ie8v3b8vPmf2C-p4Kn4</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Lu, Wan-Hsuan</creator><creator>de Souto Barreto, Philipe</creator><creator>Rolland, Yves</creator><creator>Bouyahia, Ali</creator><creator>Fischer, Clara</creator><creator>Mangin, Jean-François</creator><creator>Giudici, Kelly V</creator><creator>Vellas, Bruno</creator><general>Oxford University Press</general><general>Oxford University Press / The Gerontological Society of America</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U3</scope><scope>BHHNA</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-7824-4214</orcidid><orcidid>https://orcid.org/0000-0003-4107-8309</orcidid><orcidid>https://orcid.org/0000-0002-1142-770X</orcidid><orcidid>https://orcid.org/0009-0005-9607-9722</orcidid><orcidid>https://orcid.org/0000-0002-5802-3518</orcidid><orcidid>https://orcid.org/0000-0002-1374-1620</orcidid><orcidid>https://orcid.org/0000-0002-7678-5065</orcidid><orcidid>https://orcid.org/0000-0002-1157-0215</orcidid><orcidid>https://orcid.org/0000-0002-1671-824X</orcidid><orcidid>https://orcid.org/0009-0003-9486-9144</orcidid><orcidid>https://orcid.org/0000-0001-8690-8615</orcidid><orcidid>https://orcid.org/0000-0001-7182-9914</orcidid><orcidid>https://orcid.org/0000-0002-8860-425X</orcidid><orcidid>https://orcid.org/0000-0003-0046-2478</orcidid><orcidid>https://orcid.org/0000-0002-1185-3960</orcidid></search><sort><creationdate>20211101</creationdate><title>Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study</title><author>Lu, Wan-Hsuan ; de Souto Barreto, Philipe ; Rolland, Yves ; Bouyahia, Ali ; Fischer, Clara ; Mangin, Jean-François ; Giudici, Kelly V ; Vellas, Bruno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-aca3a9f75550a3e90b8719b8afe52ad1c2d2cebaf0c44ae2967d77a4219d6b1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease</topic><topic>Alzheimer's disease</topic><topic>Apolipoprotein E</topic><topic>Biomarkers</topic><topic>C-Reactive Protein</topic><topic>Fatty Acids, Omega-3</topic><topic>Frail Elderly</topic><topic>Frailty</topic><topic>Genotypes</topic><topic>Gerontology</topic><topic>Hippocampus</topic><topic>Homocysteine</topic><topic>Humans</topic><topic>Indexes</topic><topic>Life Sciences</topic><topic>Neuroimaging</topic><topic>Older people</topic><topic>Proteins</topic><topic>Substantia alba</topic><topic>Substantia grisea</topic><topic>β-Amyloid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Wan-Hsuan</creatorcontrib><creatorcontrib>de Souto Barreto, Philipe</creatorcontrib><creatorcontrib>Rolland, Yves</creatorcontrib><creatorcontrib>Bouyahia, Ali</creatorcontrib><creatorcontrib>Fischer, Clara</creatorcontrib><creatorcontrib>Mangin, Jean-François</creatorcontrib><creatorcontrib>Giudici, Kelly V</creatorcontrib><creatorcontrib>Vellas, Bruno</creatorcontrib><creatorcontrib>MAPT/DSA Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Social Services Abstracts</collection><collection>Sociological Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Wan-Hsuan</au><au>de Souto Barreto, Philipe</au><au>Rolland, Yves</au><au>Bouyahia, Ali</au><au>Fischer, Clara</au><au>Mangin, Jean-François</au><au>Giudici, Kelly V</au><au>Vellas, Bruno</au><aucorp>MAPT/DSA Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>76</volume><issue>11</issue><spage>e361</spage><epage>e369</epage><pages>e361-e369</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Background
This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years.
Methods
We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail at baseline (according to Fried’s criteria) and who had at least 1 post-baseline measurement of frailty. Participants who progressed to frailty during the 5-year follow-up were categorized as “incident frailty” and those who remained non-frail were categorized as “without frailty.” The differences of baseline biochemical factors (25-hydroxyvitamin D, homocysteine, omega-3 index, C-reactive protein), other biological markers (Apolipoprotein E genotypes, amyloid-β deposits), and neuroimaging data (gray matter volume, hippocampal volume, white matter hyperintensities) were compared between groups. Cox proportional hazard model was used to evaluate the associations between biomarkers and incident frailty.
Results
A total of 195 participants (14.0%) became frail over 5 years. Although 25-hydroxyvitamin D deficiency, homocysteine levels, low-grade inflammation (persistently increased C-reactive protein 3–10 mg/L), gray matter, and hippocampal volume were significantly associated with incident frailty in unadjusted models, these associations disappeared after adjustment for age, sex, and other confounders. Omega-3 index was the sole marker that presented a trend of association with incident frailty (hazard ratio: 0.92; 95% confidence interval: 0.83–1.01; p = .082).
Conclusions
This study failed to identify biomarkers able to predict frailty incidence in community-dwelling older adults for a period of 5 years. Further longitudinal research with multiple measurements of biomarkers and frailty is needed to evaluate the long-term relationships between changes in biomarkers levels and frailty evolution.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>33246338</pmid><doi>10.1093/gerona/glaa296</doi><orcidid>https://orcid.org/0000-0001-7824-4214</orcidid><orcidid>https://orcid.org/0000-0003-4107-8309</orcidid><orcidid>https://orcid.org/0000-0002-1142-770X</orcidid><orcidid>https://orcid.org/0009-0005-9607-9722</orcidid><orcidid>https://orcid.org/0000-0002-5802-3518</orcidid><orcidid>https://orcid.org/0000-0002-1374-1620</orcidid><orcidid>https://orcid.org/0000-0002-7678-5065</orcidid><orcidid>https://orcid.org/0000-0002-1157-0215</orcidid><orcidid>https://orcid.org/0000-0002-1671-824X</orcidid><orcidid>https://orcid.org/0009-0003-9486-9144</orcidid><orcidid>https://orcid.org/0000-0001-8690-8615</orcidid><orcidid>https://orcid.org/0000-0001-7182-9914</orcidid><orcidid>https://orcid.org/0000-0002-8860-425X</orcidid><orcidid>https://orcid.org/0000-0003-0046-2478</orcidid><orcidid>https://orcid.org/0000-0002-1185-3960</orcidid></addata></record> |
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| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2021-11, Vol.76 (11), p.e361-e369 |
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| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_04158260v1 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection; Sociological Abstracts |
| subjects | 25-Hydroxyvitamin D Aged Aged, 80 and over Alzheimer Disease Alzheimer's disease Apolipoprotein E Biomarkers C-Reactive Protein Fatty Acids, Omega-3 Frail Elderly Frailty Genotypes Gerontology Hippocampus Homocysteine Humans Indexes Life Sciences Neuroimaging Older people Proteins Substantia alba Substantia grisea β-Amyloid |
| title | Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study |
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