Impact of pre‐eclampsia on renal outcome in sickle cell disease patients
Summary The long‐term consequences of pre‐eclampsia (PrE) for renal function have never been determined in patients with sickle cell disease (SCD). Between 2008 and 2015, we screened 306 pregnancies in women with SCD and identified 40 with PrE (13%). The control group consisted of 65 pregnant SCD pa...
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| Veröffentlicht in: | British journal of haematology 2021-09, Vol.194 (6), p.1053-1062 |
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| creator | Boudhabhay, Idris Boutin, Emmanuelle Bartolucci, Pablo Bornes, Marie‐Isabelle Habibi, Anoosha Lionnet, François Hertig, Alexandre Grimbert, Philippe Stehlé, Thomas El Karoui, Khalil Sahali, Dil Fois, Elena Rémy, Philippe Galacteros, Frédéric Haddad, Bassam Canoui-Poitrine, Florence Lecarpentier, Edouard Audard, Vincent |
| description | Summary
The long‐term consequences of pre‐eclampsia (PrE) for renal function have never been determined in patients with sickle cell disease (SCD). Between 2008 and 2015, we screened 306 pregnancies in women with SCD and identified 40 with PrE (13%). The control group consisted of 65 pregnant SCD patients without PrE. In multivariable analysis, PrE events were associated with an increase of 1 log of lactate dehydrogenase level (adjusted odds ratio, aOR = 3·83, P = 0·05), a decrease of 10 g/l of haemoglobin levels (aOR = 2·48, P = 0·006) and one or more vaso‐occlusive crisis during pregnancy (aOR = 16·68, P = 0·002). Estimated glomerular filtration rate (eGFR) was similar in the two groups at steady state but was significantly lower in the PrE group after one year of follow‐up and at last follow‐up (130 vs 148 ml/min/1·73 m2, P |
| doi_str_mv | 10.1111/bjh.17606 |
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The long‐term consequences of pre‐eclampsia (PrE) for renal function have never been determined in patients with sickle cell disease (SCD). Between 2008 and 2015, we screened 306 pregnancies in women with SCD and identified 40 with PrE (13%). The control group consisted of 65 pregnant SCD patients without PrE. In multivariable analysis, PrE events were associated with an increase of 1 log of lactate dehydrogenase level (adjusted odds ratio, aOR = 3·83, P = 0·05), a decrease of 10 g/l of haemoglobin levels (aOR = 2·48, P = 0·006) and one or more vaso‐occlusive crisis during pregnancy (aOR = 16·68, P = 0·002). Estimated glomerular filtration rate (eGFR) was similar in the two groups at steady state but was significantly lower in the PrE group after one year of follow‐up and at last follow‐up (130 vs 148 ml/min/1·73 m2, P < 0·001 and 120 vs 130 ml/min/1·73 m2, P < 0·001, respectively). In multivariable analysis, eGFR had returned to steady‐state levels one year after pregnancy in patients without PrE but continued to decrease in patients with PrE (β = −18·15 ml/min/1·73 m2, P < 0·001). This decline was more marked at the end of follow‐up (β = −31·15 ml/min, P < 0·001). In conclusion, PrE episodes are associated with a significant risk of subsequent renal function decline in SCD patients.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/bjh.17606</identifier><identifier>PMID: 34131893</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - physiopathology ; chronic kidney disease ; Eclampsia ; Epidermal growth factor receptors ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Hematology ; Hemoglobin ; Humans ; Kidney - physiopathology ; Kidney Diseases - etiology ; Kidney Diseases - physiopathology ; L-Lactate dehydrogenase ; Lactic acid ; Life Sciences ; Pre-Eclampsia - physiopathology ; Preeclampsia ; Pregnancy ; pre‐eclampsia ; Renal function ; risk factors ; Santé publique et épidémiologie ; Sickle cell anemia ; Sickle cell disease ; sickle cell nephropathy</subject><ispartof>British journal of haematology, 2021-09, Vol.194 (6), p.1053-1062</ispartof><rights>2021 British Society for Haematology and John Wiley & Sons Ltd</rights><rights>2021 British Society for Haematology and John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4226-be9a2b697687a410dee3ee019a3c8aefdab16e565704b5efec814554cd6f2e823</citedby><cites>FETCH-LOGICAL-c4226-be9a2b697687a410dee3ee019a3c8aefdab16e565704b5efec814554cd6f2e823</cites><orcidid>0000-0001-5343-2550 ; 0000-0001-9970-6051</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjh.17606$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjh.17606$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34131893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.u-pec.fr/hal-04154485$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Boudhabhay, Idris</creatorcontrib><creatorcontrib>Boutin, Emmanuelle</creatorcontrib><creatorcontrib>Bartolucci, Pablo</creatorcontrib><creatorcontrib>Bornes, Marie‐Isabelle</creatorcontrib><creatorcontrib>Habibi, Anoosha</creatorcontrib><creatorcontrib>Lionnet, François</creatorcontrib><creatorcontrib>Hertig, Alexandre</creatorcontrib><creatorcontrib>Grimbert, Philippe</creatorcontrib><creatorcontrib>Stehlé, Thomas</creatorcontrib><creatorcontrib>El Karoui, Khalil</creatorcontrib><creatorcontrib>Sahali, Dil</creatorcontrib><creatorcontrib>Fois, Elena</creatorcontrib><creatorcontrib>Rémy, Philippe</creatorcontrib><creatorcontrib>Galacteros, Frédéric</creatorcontrib><creatorcontrib>Haddad, Bassam</creatorcontrib><creatorcontrib>Canoui-Poitrine, Florence</creatorcontrib><creatorcontrib>Lecarpentier, Edouard</creatorcontrib><creatorcontrib>Audard, Vincent</creatorcontrib><title>Impact of pre‐eclampsia on renal outcome in sickle cell disease patients</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
The long‐term consequences of pre‐eclampsia (PrE) for renal function have never been determined in patients with sickle cell disease (SCD). Between 2008 and 2015, we screened 306 pregnancies in women with SCD and identified 40 with PrE (13%). The control group consisted of 65 pregnant SCD patients without PrE. In multivariable analysis, PrE events were associated with an increase of 1 log of lactate dehydrogenase level (adjusted odds ratio, aOR = 3·83, P = 0·05), a decrease of 10 g/l of haemoglobin levels (aOR = 2·48, P = 0·006) and one or more vaso‐occlusive crisis during pregnancy (aOR = 16·68, P = 0·002). Estimated glomerular filtration rate (eGFR) was similar in the two groups at steady state but was significantly lower in the PrE group after one year of follow‐up and at last follow‐up (130 vs 148 ml/min/1·73 m2, P < 0·001 and 120 vs 130 ml/min/1·73 m2, P < 0·001, respectively). In multivariable analysis, eGFR had returned to steady‐state levels one year after pregnancy in patients without PrE but continued to decrease in patients with PrE (β = −18·15 ml/min/1·73 m2, P < 0·001). This decline was more marked at the end of follow‐up (β = −31·15 ml/min, P < 0·001). In conclusion, PrE episodes are associated with a significant risk of subsequent renal function decline in SCD patients.</description><subject>Adult</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - physiopathology</subject><subject>chronic kidney disease</subject><subject>Eclampsia</subject><subject>Epidermal growth factor receptors</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glomerular Filtration Rate</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Kidney - physiopathology</subject><subject>Kidney Diseases - etiology</subject><subject>Kidney Diseases - physiopathology</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Life Sciences</subject><subject>Pre-Eclampsia - physiopathology</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>pre‐eclampsia</subject><subject>Renal function</subject><subject>risk factors</subject><subject>Santé publique et épidémiologie</subject><subject>Sickle cell anemia</subject><subject>Sickle cell disease</subject><subject>sickle cell nephropathy</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9K5EAQxhtZ0Vn14AtIw17cQ7Qr_S85qqyOMuBFz02nU8Eek3RMJ4q3fYR9xn0SM46KCNaloPjx1Vf1EbIP7AimOi6Wd0egFVMbZAZcySQFAT_IjDGmE2Ai2yY_Y1wyBpxJ2CLbXACHLOczcnXZdNYNNFS06_H_33_oatt00VsaWtpja2saxsGFBqlvafTuvkbqsK5p6SPaiLSzg8d2iLtks7J1xL23vkNuz__cnM2TxfXF5dnJInEiTVVSYG7TQuVaZdoKYCUiR2SQW-4yi1VpC1AoldRMFBIrdBkIKYUrVZVilvId8nute2dr0_W-sf2zCdab-cnCrGZMgBQik48wsYdrtuvDw4hxMI2PK_e2xTBGk0oBOtNS6gn99QVdhrGf7l9ROs0nC_zTcteHGHusPhwAM6swzBSGeQ1jYg_eFMeiwfKDfP_-BByvgSdf4_P3Sub0ar6WfAFvXZIw</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Boudhabhay, Idris</creator><creator>Boutin, Emmanuelle</creator><creator>Bartolucci, Pablo</creator><creator>Bornes, Marie‐Isabelle</creator><creator>Habibi, Anoosha</creator><creator>Lionnet, François</creator><creator>Hertig, Alexandre</creator><creator>Grimbert, Philippe</creator><creator>Stehlé, Thomas</creator><creator>El Karoui, Khalil</creator><creator>Sahali, Dil</creator><creator>Fois, Elena</creator><creator>Rémy, Philippe</creator><creator>Galacteros, Frédéric</creator><creator>Haddad, Bassam</creator><creator>Canoui-Poitrine, Florence</creator><creator>Lecarpentier, Edouard</creator><creator>Audard, Vincent</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-5343-2550</orcidid><orcidid>https://orcid.org/0000-0001-9970-6051</orcidid></search><sort><creationdate>202109</creationdate><title>Impact of pre‐eclampsia on renal outcome in sickle cell disease patients</title><author>Boudhabhay, Idris ; Boutin, Emmanuelle ; Bartolucci, Pablo ; Bornes, Marie‐Isabelle ; Habibi, Anoosha ; Lionnet, François ; Hertig, Alexandre ; Grimbert, Philippe ; Stehlé, Thomas ; El Karoui, Khalil ; Sahali, Dil ; Fois, Elena ; Rémy, Philippe ; Galacteros, Frédéric ; Haddad, Bassam ; Canoui-Poitrine, Florence ; Lecarpentier, Edouard ; Audard, Vincent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4226-be9a2b697687a410dee3ee019a3c8aefdab16e565704b5efec814554cd6f2e823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - physiopathology</topic><topic>chronic kidney disease</topic><topic>Eclampsia</topic><topic>Epidermal growth factor receptors</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glomerular Filtration Rate</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Kidney - physiopathology</topic><topic>Kidney Diseases - etiology</topic><topic>Kidney Diseases - physiopathology</topic><topic>L-Lactate dehydrogenase</topic><topic>Lactic acid</topic><topic>Life Sciences</topic><topic>Pre-Eclampsia - physiopathology</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>pre‐eclampsia</topic><topic>Renal function</topic><topic>risk factors</topic><topic>Santé publique et épidémiologie</topic><topic>Sickle cell anemia</topic><topic>Sickle cell disease</topic><topic>sickle cell nephropathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boudhabhay, Idris</creatorcontrib><creatorcontrib>Boutin, Emmanuelle</creatorcontrib><creatorcontrib>Bartolucci, Pablo</creatorcontrib><creatorcontrib>Bornes, Marie‐Isabelle</creatorcontrib><creatorcontrib>Habibi, Anoosha</creatorcontrib><creatorcontrib>Lionnet, François</creatorcontrib><creatorcontrib>Hertig, Alexandre</creatorcontrib><creatorcontrib>Grimbert, Philippe</creatorcontrib><creatorcontrib>Stehlé, Thomas</creatorcontrib><creatorcontrib>El Karoui, Khalil</creatorcontrib><creatorcontrib>Sahali, Dil</creatorcontrib><creatorcontrib>Fois, Elena</creatorcontrib><creatorcontrib>Rémy, Philippe</creatorcontrib><creatorcontrib>Galacteros, Frédéric</creatorcontrib><creatorcontrib>Haddad, Bassam</creatorcontrib><creatorcontrib>Canoui-Poitrine, Florence</creatorcontrib><creatorcontrib>Lecarpentier, Edouard</creatorcontrib><creatorcontrib>Audard, Vincent</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boudhabhay, Idris</au><au>Boutin, Emmanuelle</au><au>Bartolucci, Pablo</au><au>Bornes, Marie‐Isabelle</au><au>Habibi, Anoosha</au><au>Lionnet, François</au><au>Hertig, Alexandre</au><au>Grimbert, Philippe</au><au>Stehlé, Thomas</au><au>El Karoui, Khalil</au><au>Sahali, Dil</au><au>Fois, Elena</au><au>Rémy, Philippe</au><au>Galacteros, Frédéric</au><au>Haddad, Bassam</au><au>Canoui-Poitrine, Florence</au><au>Lecarpentier, Edouard</au><au>Audard, Vincent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of pre‐eclampsia on renal outcome in sickle cell disease patients</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2021-09</date><risdate>2021</risdate><volume>194</volume><issue>6</issue><spage>1053</spage><epage>1062</epage><pages>1053-1062</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><abstract>Summary
The long‐term consequences of pre‐eclampsia (PrE) for renal function have never been determined in patients with sickle cell disease (SCD). Between 2008 and 2015, we screened 306 pregnancies in women with SCD and identified 40 with PrE (13%). The control group consisted of 65 pregnant SCD patients without PrE. In multivariable analysis, PrE events were associated with an increase of 1 log of lactate dehydrogenase level (adjusted odds ratio, aOR = 3·83, P = 0·05), a decrease of 10 g/l of haemoglobin levels (aOR = 2·48, P = 0·006) and one or more vaso‐occlusive crisis during pregnancy (aOR = 16·68, P = 0·002). Estimated glomerular filtration rate (eGFR) was similar in the two groups at steady state but was significantly lower in the PrE group after one year of follow‐up and at last follow‐up (130 vs 148 ml/min/1·73 m2, P < 0·001 and 120 vs 130 ml/min/1·73 m2, P < 0·001, respectively). In multivariable analysis, eGFR had returned to steady‐state levels one year after pregnancy in patients without PrE but continued to decrease in patients with PrE (β = −18·15 ml/min/1·73 m2, P < 0·001). This decline was more marked at the end of follow‐up (β = −31·15 ml/min, P < 0·001). In conclusion, PrE episodes are associated with a significant risk of subsequent renal function decline in SCD patients.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>34131893</pmid><doi>10.1111/bjh.17606</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5343-2550</orcidid><orcidid>https://orcid.org/0000-0001-9970-6051</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anemia, Sickle Cell - complications Anemia, Sickle Cell - physiopathology chronic kidney disease Eclampsia Epidermal growth factor receptors Female Follow-Up Studies Glomerular Filtration Rate Hematology Hemoglobin Humans Kidney - physiopathology Kidney Diseases - etiology Kidney Diseases - physiopathology L-Lactate dehydrogenase Lactic acid Life Sciences Pre-Eclampsia - physiopathology Preeclampsia Pregnancy pre‐eclampsia Renal function risk factors Santé publique et épidémiologie Sickle cell anemia Sickle cell disease sickle cell nephropathy |
| title | Impact of pre‐eclampsia on renal outcome in sickle cell disease patients |
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