Knowledge and practices about safe handling regarding the risk of exposure to antineoplastic drugs for caregivers in compounding units and in operating rooms performing HIPEC/PIPAC
Introduction Ever since the late 1970s, occupational exposure associated with the handling of antineoplastic drugs (ADs) in the healthcare environment has been highlighted and demonstrated. Contamination was detected in both operating rooms (OR) and compounding units (CU), where healthcare workers h...
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| Veröffentlicht in: | Journal of oncology pharmacy practice 2023-10, Vol.29 (7), p.1628-1636 |
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| creator | Delafoy, Clémence Benoist, Hubert Patin, Alex Vasseur, Michèle Guillouet, Sonia Eveno, Clarisse Guilloit, Jean-Marc Odou, Pascal Simon, Nicolas Saint-Lorant, Guillaume |
| description | Introduction
Ever since the late 1970s, occupational exposure associated with the handling of antineoplastic drugs (ADs) in the healthcare environment has been highlighted and demonstrated. Contamination was detected in both operating rooms (OR) and compounding units (CU), where healthcare workers handle and are exposed to ADs in different ways. In the OR, the risk of exposure is higher and the staff receives less training in handling ADs than in the CU. This study aimed to assess and compare knowledge and practices about the safe handling of ADs by caregivers working in these two locations, namely the CU and OR.
Methods
Two questionnaires (one each for the OR and CU) were created by two investigator pharmacists and were completed during a personal interview of 20 min. The questions were related to the following topics: training, knowledge about occupational exposure and questions related to protective practices. A scoring system was implemented to assess the knowledge and practices of each participant.
Results
In total, 38 caregivers working in the OR and 39 in the CU were included in our study. Significantly more CU staff had specific initial training (p |
| doi_str_mv | 10.1177/10781552221144303 |
| format | Article |
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Ever since the late 1970s, occupational exposure associated with the handling of antineoplastic drugs (ADs) in the healthcare environment has been highlighted and demonstrated. Contamination was detected in both operating rooms (OR) and compounding units (CU), where healthcare workers handle and are exposed to ADs in different ways. In the OR, the risk of exposure is higher and the staff receives less training in handling ADs than in the CU. This study aimed to assess and compare knowledge and practices about the safe handling of ADs by caregivers working in these two locations, namely the CU and OR.
Methods
Two questionnaires (one each for the OR and CU) were created by two investigator pharmacists and were completed during a personal interview of 20 min. The questions were related to the following topics: training, knowledge about occupational exposure and questions related to protective practices. A scoring system was implemented to assess the knowledge and practices of each participant.
Results
In total, 38 caregivers working in the OR and 39 in the CU were included in our study. Significantly more CU staff had specific initial training (p < 0.001) and ongoing training (p < 0.001) in handling ADs. Concerning the knowledge score, OR caregivers had a significantly lower median score for contamination routes (p < 0.001), contamination surfaces (p < 0.001), existing procedures (p < 0.001) and total knowledge (p < 0.001) than CU caregivers. Concerning protective handling practices of ADs, the two locations had nonsignificantly different median scores (p = 0.892).
Conclusion
This study suggests that there is still room for improvement in terms of knowledge and protection practices when handling ADs. An appropriate and tailored training program should be developed and provided to all caregivers who handle or come in contact with ADs.
Clinical trial registration
Study CONTACT, ref. 19-504.]]></description><identifier>ISSN: 1078-1552</identifier><identifier>EISSN: 1477-092X</identifier><identifier>DOI: 10.1177/10781552221144303</identifier><identifier>PMID: 36514878</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Antineoplastic drugs ; Caregivers ; Contamination ; Health care ; Knowledge ; Life Sciences ; Medical personnel ; Occupational exposure</subject><ispartof>Journal of oncology pharmacy practice, 2023-10, Vol.29 (7), p.1628-1636</ispartof><rights>The Author(s) 2022</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-84d354c9436fccff12e3eea607d87e9fdf120e54a6059daea30ebdf8958e8e463</citedby><cites>FETCH-LOGICAL-c402t-84d354c9436fccff12e3eea607d87e9fdf120e54a6059daea30ebdf8958e8e463</cites><orcidid>0000-0001-8429-6539 ; 0000-0003-1295-2191 ; 0000-0001-5257-440X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/10781552221144303$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/10781552221144303$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,776,780,881,21799,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36514878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-lille.fr/hal-04152044$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Delafoy, Clémence</creatorcontrib><creatorcontrib>Benoist, Hubert</creatorcontrib><creatorcontrib>Patin, Alex</creatorcontrib><creatorcontrib>Vasseur, Michèle</creatorcontrib><creatorcontrib>Guillouet, Sonia</creatorcontrib><creatorcontrib>Eveno, Clarisse</creatorcontrib><creatorcontrib>Guilloit, Jean-Marc</creatorcontrib><creatorcontrib>Odou, Pascal</creatorcontrib><creatorcontrib>Simon, Nicolas</creatorcontrib><creatorcontrib>Saint-Lorant, Guillaume</creatorcontrib><title>Knowledge and practices about safe handling regarding the risk of exposure to antineoplastic drugs for caregivers in compounding units and in operating rooms performing HIPEC/PIPAC</title><title>Journal of oncology pharmacy practice</title><addtitle>J Oncol Pharm Pract</addtitle><description><![CDATA[Introduction
Ever since the late 1970s, occupational exposure associated with the handling of antineoplastic drugs (ADs) in the healthcare environment has been highlighted and demonstrated. Contamination was detected in both operating rooms (OR) and compounding units (CU), where healthcare workers handle and are exposed to ADs in different ways. In the OR, the risk of exposure is higher and the staff receives less training in handling ADs than in the CU. This study aimed to assess and compare knowledge and practices about the safe handling of ADs by caregivers working in these two locations, namely the CU and OR.
Methods
Two questionnaires (one each for the OR and CU) were created by two investigator pharmacists and were completed during a personal interview of 20 min. The questions were related to the following topics: training, knowledge about occupational exposure and questions related to protective practices. A scoring system was implemented to assess the knowledge and practices of each participant.
Results
In total, 38 caregivers working in the OR and 39 in the CU were included in our study. Significantly more CU staff had specific initial training (p < 0.001) and ongoing training (p < 0.001) in handling ADs. Concerning the knowledge score, OR caregivers had a significantly lower median score for contamination routes (p < 0.001), contamination surfaces (p < 0.001), existing procedures (p < 0.001) and total knowledge (p < 0.001) than CU caregivers. Concerning protective handling practices of ADs, the two locations had nonsignificantly different median scores (p = 0.892).
Conclusion
This study suggests that there is still room for improvement in terms of knowledge and protection practices when handling ADs. An appropriate and tailored training program should be developed and provided to all caregivers who handle or come in contact with ADs.
Clinical trial registration
Study CONTACT, ref. 19-504.]]></description><subject>Antineoplastic drugs</subject><subject>Caregivers</subject><subject>Contamination</subject><subject>Health care</subject><subject>Knowledge</subject><subject>Life Sciences</subject><subject>Medical personnel</subject><subject>Occupational exposure</subject><issn>1078-1552</issn><issn>1477-092X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kdGO1CAUhhujcdfVB_DGkHizXnQXKAz0cjJZnYmTOBeaeNcwcOiwtqUCXfW9fEDpzLomGq-A_3z_f4BTFC8JviJEiGuChSScU0oJYazC1aPinDAhSlzTz4_zPtfLGTgrnsV4izGWgsqnxVm14IRJIc-Ln-8H_60D0wJSg0FjUDo5DRGpvZ8SisoCOuRK54YWBWhVMPMuHQAFF78gbxF8H32cAqDkc0ZyA_ixUzHHIBOmNiLrA9Iqm90dhIjcgLTvRz8Nx6hpcCkem-eCHyGodOzlfR9RPmZ3Pwvrze5mdb3b7Jar58UTq7oIL-7Xi-LT25uPq3W5_fBus1puS80wTaVkpuJM16xaWK2tJRQqALXAwkgBtTVZwcBZVnhtFKgKw95YWXMJEtiiuijenHIPqmvG4HoVfjReuWa93DazhhnhFDN2RzJ7eWLH4L9OEFPTu6ih61T-jyk2VHDGMZOSZ_T1X-itn8KQX9JQKankohI0U-RE6eBjDGAfbkBwM4-_-Wf82fPqPnna92AeHL_nnYGrExBVC3_a_j_xF4unuf4</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Delafoy, Clémence</creator><creator>Benoist, Hubert</creator><creator>Patin, Alex</creator><creator>Vasseur, Michèle</creator><creator>Guillouet, Sonia</creator><creator>Eveno, Clarisse</creator><creator>Guilloit, Jean-Marc</creator><creator>Odou, Pascal</creator><creator>Simon, Nicolas</creator><creator>Saint-Lorant, Guillaume</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-8429-6539</orcidid><orcidid>https://orcid.org/0000-0003-1295-2191</orcidid><orcidid>https://orcid.org/0000-0001-5257-440X</orcidid></search><sort><creationdate>20231001</creationdate><title>Knowledge and practices about safe handling regarding the risk of exposure to antineoplastic drugs for caregivers in compounding units and in operating rooms performing HIPEC/PIPAC</title><author>Delafoy, Clémence ; Benoist, Hubert ; Patin, Alex ; Vasseur, Michèle ; Guillouet, Sonia ; Eveno, Clarisse ; Guilloit, Jean-Marc ; Odou, Pascal ; Simon, Nicolas ; Saint-Lorant, Guillaume</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-84d354c9436fccff12e3eea607d87e9fdf120e54a6059daea30ebdf8958e8e463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antineoplastic drugs</topic><topic>Caregivers</topic><topic>Contamination</topic><topic>Health care</topic><topic>Knowledge</topic><topic>Life Sciences</topic><topic>Medical personnel</topic><topic>Occupational exposure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delafoy, Clémence</creatorcontrib><creatorcontrib>Benoist, Hubert</creatorcontrib><creatorcontrib>Patin, Alex</creatorcontrib><creatorcontrib>Vasseur, Michèle</creatorcontrib><creatorcontrib>Guillouet, Sonia</creatorcontrib><creatorcontrib>Eveno, Clarisse</creatorcontrib><creatorcontrib>Guilloit, Jean-Marc</creatorcontrib><creatorcontrib>Odou, Pascal</creatorcontrib><creatorcontrib>Simon, Nicolas</creatorcontrib><creatorcontrib>Saint-Lorant, Guillaume</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of oncology pharmacy practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delafoy, Clémence</au><au>Benoist, Hubert</au><au>Patin, Alex</au><au>Vasseur, Michèle</au><au>Guillouet, Sonia</au><au>Eveno, Clarisse</au><au>Guilloit, Jean-Marc</au><au>Odou, Pascal</au><au>Simon, Nicolas</au><au>Saint-Lorant, Guillaume</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Knowledge and practices about safe handling regarding the risk of exposure to antineoplastic drugs for caregivers in compounding units and in operating rooms performing HIPEC/PIPAC</atitle><jtitle>Journal of oncology pharmacy practice</jtitle><addtitle>J Oncol Pharm Pract</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>29</volume><issue>7</issue><spage>1628</spage><epage>1636</epage><pages>1628-1636</pages><issn>1078-1552</issn><eissn>1477-092X</eissn><abstract><![CDATA[Introduction
Ever since the late 1970s, occupational exposure associated with the handling of antineoplastic drugs (ADs) in the healthcare environment has been highlighted and demonstrated. Contamination was detected in both operating rooms (OR) and compounding units (CU), where healthcare workers handle and are exposed to ADs in different ways. In the OR, the risk of exposure is higher and the staff receives less training in handling ADs than in the CU. This study aimed to assess and compare knowledge and practices about the safe handling of ADs by caregivers working in these two locations, namely the CU and OR.
Methods
Two questionnaires (one each for the OR and CU) were created by two investigator pharmacists and were completed during a personal interview of 20 min. The questions were related to the following topics: training, knowledge about occupational exposure and questions related to protective practices. A scoring system was implemented to assess the knowledge and practices of each participant.
Results
In total, 38 caregivers working in the OR and 39 in the CU were included in our study. Significantly more CU staff had specific initial training (p < 0.001) and ongoing training (p < 0.001) in handling ADs. Concerning the knowledge score, OR caregivers had a significantly lower median score for contamination routes (p < 0.001), contamination surfaces (p < 0.001), existing procedures (p < 0.001) and total knowledge (p < 0.001) than CU caregivers. Concerning protective handling practices of ADs, the two locations had nonsignificantly different median scores (p = 0.892).
Conclusion
This study suggests that there is still room for improvement in terms of knowledge and protection practices when handling ADs. An appropriate and tailored training program should be developed and provided to all caregivers who handle or come in contact with ADs.
Clinical trial registration
Study CONTACT, ref. 19-504.]]></abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>36514878</pmid><doi>10.1177/10781552221144303</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8429-6539</orcidid><orcidid>https://orcid.org/0000-0003-1295-2191</orcidid><orcidid>https://orcid.org/0000-0001-5257-440X</orcidid></addata></record> |
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| identifier | ISSN: 1078-1552 |
| ispartof | Journal of oncology pharmacy practice, 2023-10, Vol.29 (7), p.1628-1636 |
| issn | 1078-1552 1477-092X |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_04152044v1 |
| source | SAGE Complete A-Z List |
| subjects | Antineoplastic drugs Caregivers Contamination Health care Knowledge Life Sciences Medical personnel Occupational exposure |
| title | Knowledge and practices about safe handling regarding the risk of exposure to antineoplastic drugs for caregivers in compounding units and in operating rooms performing HIPEC/PIPAC |
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