MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice

MAGT1 (magnesium transporter 1) is a subunit of the oligosaccharide protein complex with thiol-disulfide oxidoreductase activity, supporting the process of N-glycosylation. MAGT1 deficiency was detected in human patients with X-linked immunodeficiency with magnesium defect syndrome and congenital di...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2023-08, Vol.43 (8), p.1494-1509
Hauptverfasser:	Gotru, Sanjeev Kiran, Mammadova-Bach, Elmina, Sogkas, Georgios, Schuhmann, Michael K., Schmitt, Karen, Kraft, Peter, Herterich, Sabine, Mamtimin, Medina, Pinarci, Akif, Beck, Sarah, Stritt, Simon, Han, Chao, Ren, Pengxuan, Freund, Jean-Noël, Klemann, Christian, Ringshausen, Felix C., Heemskerk, Johan W.M., Dietrich, Alexander, Nieswandt, Bernhard, Stoll, Guido, Gudermann, Thomas, Braun, Attila
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Platelets - metabolism Calcium - metabolism Cation Transport Proteins - deficiency Cations - metabolism Cellular Biology Homeostasis Humans Infarction, Middle Cerebral Artery Ischemic Stroke - complications Ischemic Stroke - genetics Ischemic Stroke - metabolism Life Sciences Magnesium - metabolism Mice Platelet Activation Platelet Aggregation Platelet Membrane Glycoproteins - metabolism Thrombosis - genetics Thrombosis - metabolism TRPC6 Cation Channel - metabolism
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