Metalloglycobiology: The power of metals in regulating glycosylation
The remarkable structural diversity of glycans that is exposed at the cell surface and generated along the secretory pathway is tightly regulated by several factors. The recent identification of human glycosylation diseases related to metal transporter defects opened a completely new field of invest...
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| Veröffentlicht in: | Biochimica et biophysica acta. General subjects 2023-09, Vol.1867 (9), p.130412-130412, Article 130412 |
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| container_title | Biochimica et biophysica acta. General subjects |
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| creator | Durin, Zoé Houdou, Marine Legrand, Dominique Foulquier, François |
| description | The remarkable structural diversity of glycans that is exposed at the cell surface and generated along the secretory pathway is tightly regulated by several factors. The recent identification of human glycosylation diseases related to metal transporter defects opened a completely new field of investigation, referred to herein as “metalloglycobiology”, on how metal changes can affect the glycosylation and hence the glycan structures that are produced. Although this field is in its infancy, this review aims to go through the different glycosylation steps/pathways that are metal dependent and that could be impacted by metal homeostasis dysregulations.
•The remarkable structural diversity of glycans is regulated by metals.•Metal changes can lead to human glycosylation diseases.•Metalloglycobiology field is in its infancy. |
| doi_str_mv | 10.1016/j.bbagen.2023.130412 |
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| identifier | ISSN: 0304-4165 |
| ispartof | Biochimica et biophysica acta. General subjects, 2023-09, Vol.1867 (9), p.130412-130412, Article 130412 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biochemistry Biochemistry, Molecular Biology CDG Congenital Disorders of Glycosylation - metabolism Glycosylation Homeostasis Humans Life Sciences Membrane Transport Proteins - metabolism Metals Polysaccharides - metabolism Regulation |
| title | Metalloglycobiology: The power of metals in regulating glycosylation |
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