Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Patterning of the mouse embryo along the anteroposterior axis during body plan development requires migration of the distal visceral endoderm (DVE) towards the future anterior side by a mechanism that has remained unknown. Here we show that Nodal signalling and the regionalization of its antagonists...

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Veröffentlicht in:	Nature 2004-03, Vol.428 (6981), p.387-392
Hauptverfasser:	Yamamoto, Masamichi, Saijoh, Yukio, Perea-Gomez, Aitana, Shawlot, William, Behringer, Richard R., Ang, Siew-Lan, Hamada, Hiroshi, Meno, Chikara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Patterning - drug effects Cell Division - drug effects Cell Movement Cellular biology Cerl protein Cytokines Development Biology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Early stages. Segmentation. Gastrulation. Neurulation Embryo, Mammalian - cytology Embryo, Mammalian - drug effects Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Embryology: invertebrates and vertebrates. Teratology Embryos Endoderm - cytology Endoderm - drug effects Endoderm - metabolism Forkhead Transcription Factors Fundamental and applied biological sciences. Psychology Gene Deletion Gene Expression Regulation, Developmental Genetics Humanities and Social Sciences In Situ Hybridization Left-Right Determination Factors Lefty1 protein Life Sciences Mice multidisciplinary Nodal Protein Proteins - genetics Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Science Science (multidisciplinary) Signal Transduction - drug effects Transcription Factors - genetics Transcription Factors - metabolism Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism
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