Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo
Patterning of the mouse embryo along the anteroposterior axis during body plan development requires migration of the distal visceral endoderm (DVE) towards the future anterior side by a mechanism that has remained unknown. Here we show that Nodal signalling and the regionalization of its antagonists...
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| Veröffentlicht in: | Nature 2004-03, Vol.428 (6981), p.387-392 |
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| creator | Yamamoto, Masamichi Saijoh, Yukio Perea-Gomez, Aitana Shawlot, William Behringer, Richard R. Ang, Siew-Lan Hamada, Hiroshi Meno, Chikara |
| description | Patterning of the mouse embryo along the anteroposterior axis during body plan development requires migration of the distal visceral endoderm (DVE) towards the future anterior side by a mechanism that has remained unknown. Here we show that Nodal signalling and the regionalization of its antagonists are required for normal migration of the DVE. Whereas Nodal signalling provides the driving force for DVE migration by stimulating the proliferation of visceral endoderm cells, the antagonists Lefty1 and Cerl determine the direction of migration by asymmetrically inhibiting Nodal activity on the future anterior side. |
| doi_str_mv | 10.1038/nature02418 |
| format | Article |
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Here we show that Nodal signalling and the regionalization of its antagonists are required for normal migration of the DVE. Whereas Nodal signalling provides the driving force for DVE migration by stimulating the proliferation of visceral endoderm cells, the antagonists Lefty1 and Cerl determine the direction of migration by asymmetrically inhibiting Nodal activity on the future anterior side.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/nature02418</identifier><identifier>PMID: 15004567</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biological and medical sciences ; Body Patterning - drug effects ; Cell Division - drug effects ; Cell Movement ; Cellular biology ; Cerl protein ; Cytokines ; Development Biology ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Early stages. Segmentation. Gastrulation. Neurulation ; Embryo, Mammalian - cytology ; Embryo, Mammalian - drug effects ; Embryo, Mammalian - embryology ; Embryo, Mammalian - metabolism ; Embryology: invertebrates and vertebrates. Teratology ; Embryos ; Endoderm - cytology ; Endoderm - drug effects ; Endoderm - metabolism ; Forkhead Transcription Factors ; Fundamental and applied biological sciences. Psychology ; Gene Deletion ; Gene Expression Regulation, Developmental ; Genetics ; Humanities and Social Sciences ; In Situ Hybridization ; Left-Right Determination Factors ; Lefty1 protein ; Life Sciences ; Mice ; multidisciplinary ; Nodal Protein ; Proteins - genetics ; Proteins - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Rodents ; Science ; Science (multidisciplinary) ; Signal Transduction - drug effects ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transforming Growth Factor beta - antagonists & inhibitors ; Transforming Growth Factor beta - genetics ; Transforming Growth Factor beta - metabolism</subject><ispartof>Nature, 2004-03, Vol.428 (6981), p.387-392</ispartof><rights>Macmillan Magazines Ltd. 2004</rights><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2004 Nature Publishing Group</rights><rights>Copyright Macmillan Journals Ltd. 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Here we show that Nodal signalling and the regionalization of its antagonists are required for normal migration of the DVE. Whereas Nodal signalling provides the driving force for DVE migration by stimulating the proliferation of visceral endoderm cells, the antagonists Lefty1 and Cerl determine the direction of migration by asymmetrically inhibiting Nodal activity on the future anterior side.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Patterning - drug effects</subject><subject>Cell Division - drug effects</subject><subject>Cell Movement</subject><subject>Cellular biology</subject><subject>Cerl protein</subject><subject>Cytokines</subject><subject>Development Biology</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Early stages. Segmentation. Gastrulation. 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| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature, 2004-03, Vol.428 (6981), p.387-392 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_04132972v1 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | Animals Biological and medical sciences Body Patterning - drug effects Cell Division - drug effects Cell Movement Cellular biology Cerl protein Cytokines Development Biology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Early stages. Segmentation. Gastrulation. Neurulation Embryo, Mammalian - cytology Embryo, Mammalian - drug effects Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Embryology: invertebrates and vertebrates. Teratology Embryos Endoderm - cytology Endoderm - drug effects Endoderm - metabolism Forkhead Transcription Factors Fundamental and applied biological sciences. Psychology Gene Deletion Gene Expression Regulation, Developmental Genetics Humanities and Social Sciences In Situ Hybridization Left-Right Determination Factors Lefty1 protein Life Sciences Mice multidisciplinary Nodal Protein Proteins - genetics Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Science Science (multidisciplinary) Signal Transduction - drug effects Transcription Factors - genetics Transcription Factors - metabolism Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism |
| title | Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T21%3A23%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nodal%20antagonists%20regulate%20formation%20of%20the%20anteroposterior%20axis%20of%20the%20mouse%20embryo&rft.jtitle=Nature&rft.au=Yamamoto,%20Masamichi&rft.date=2004-03-25&rft.volume=428&rft.issue=6981&rft.spage=387&rft.epage=392&rft.pages=387-392&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/nature02418&rft_dat=%3Cgale_hal_p%3EA186371174%3C/gale_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204559448&rft_id=info:pmid/15004567&rft_galeid=A186371174&rfr_iscdi=true |