Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling Complex

Alterations in chromatin play an important role in oncogenic transformation, although the underlying mechanisms are often poorly understood. The SWI/SNF complex contributes to epigenetic regulation by using the energy of ATP hydrolysis to remodel chromatin and thus regulate transcription of target g...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-10, Vol.69 (20), p.8094-8101
Hauptverfasser:	XI WANG, SANSAM, Courtney G, THOM, Christopher S, METZGER, Daniel, EVANS, Julia A, NGUYEN, Phuong T. L, ROBERTS, Charles W. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Animals Antineoplastic agents Biochemistry, Molecular Biology Biological and medical sciences Blotting, Western Cells, Cultured Chromatin Assembly and Disassembly Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism DNA Helicases - antagonists & inhibitors DNA Helicases - genetics DNA Helicases - metabolism Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Fibroblasts - metabolism HeLa Cells Humans Life Sciences Medical sciences Mice Mice, Knockout Neoplasms - metabolism Neoplasms - pathology Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism Pharmacology. Drug treatments Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - pharmacology SMARCB1 Protein Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism Tumors
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