sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish

In looking for novel factors involved in the regulation of the fibroblast growth factor (FGF) signaling pathway, we have isolated a zebrafish sprouty4 gene, based on its extensive similarities with the expression patterns of both fgf8 and fgf3 . Through gain- and loss-of-function experiments, we dem...

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Veröffentlicht in:	Development (Cambridge) 2001-06, Vol.128 (12), p.2175-2186
Hauptverfasser:	Fürthauer, M, Reifers, F, Brand, M, Thisse, B, Thisse, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Cerebellum - abnormalities Cerebellum - embryology Cerebellum - metabolism Danio rerio DNA, Complementary Fibroblast Growth Factor 3 Fibroblast Growth Factor 8 Fibroblast Growth Factors - antagonists & inhibitors Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism Fibroblast Growth Factors - physiology Freshwater Gene Expression Profiling Life Sciences Molecular Sequence Data Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Phenotype Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Receptor Protein-Tyrosine Kinases - metabolism Receptor, Fibroblast Growth Factor, Type 1 Receptors, Fibroblast Growth Factor - metabolism Signal Transduction sprouty4 gene Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins
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