BCG∆BCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice

•BCG△BCG1419c increased autophagy in murine macrophages compared with BCG.•BCG△BCG1419c differs in c-di-GMP content compared with BCG.•BCG△BCG1419c has a different proteome compared with BCG.•BCG△BCG1419c delayed progression of lung pathology in Mtb HN878-infected mice. The efficacy of BCG vaccines...

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Veröffentlicht in:	Vaccine 2023-06, Vol.41 (26), p.3824-3835
Hauptverfasser:	Aceves-Sánchez, Michel de Jesús, Barrios-Payán, Jorge Alberto, Segura-Cerda, Cristian Alfredo, Flores-Valdez, Mario Alberto, Mata-Espinosa, Dulce, Pedroza-Roldán, César, Yadav, Rahul, Saini, Deepak Kumar, de la Cruz, Miguel Angel, Ares, Miguel A., Bielefeldt-Ohmann, Helle, Baay-Guzmán, Guillermina, Vergne, Isabelle, Velázquez-Fernández, Jesús Bernardino, Barba León, Jeannette, Hernández-Pando, Rogelio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Bacteria Bacteriology BCG BCG Vaccine BCG∆BCG1419c Beijing Biofilms Biosensors Coding Degradation Glycerol HN878 Human health and pathology Humans Hypotheses Immunization Immunology Infections Infectious diseases Life Sciences Lung Lungs Macrophages Male Mice Mice, Inbred BALB C Microbiology and Parasitology Mycobacterium bovis Mycobacterium tuberculosis Necrosis Pathology Proteins Proteome Proteomes Proteomics Tuberculosis Tuberculosis - prevention & control Vaccines Vaccinology
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