Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses

The role of the opioid system in controlling pain 1 , reward and addiction 2 , 3 is well established, but its role in regulating other emotional responses is poorly documented in pharmacology 4 . The μ-, δ- and κ- opioid receptors (encoded by Oprm, Oprd1 and Oprk1 , respectively) mediate the biologi...

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Veröffentlicht in:	Nature genetics 2000-06, Vol.25 (2), p.195-200
Hauptverfasser:	Filliol, Dominique, Ghozland, Sandy, Chluba, Johanna, Martin, Miguel, Matthes, Hans W.D., Simonin, Frédéric, Befort, Katia, Gavériaux-Ruff, Claire, Dierich, Andrée, LeMeur, Marianne, Valverde, Olga, Maldonado, Rafael, Kieffer, Brigitte L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Anxiety Anxiety - genetics Anxiety - metabolism Binding Sites Biomedical and Life Sciences Biomedicine Cancer Research Darkness Depression - genetics Depression - metabolism Depression, Mental Electroshock Female Gene Deletion Gene Function Genetic aspects Genetics Health aspects Human Genetics letter Life Sciences Light Male Mice Mice, Knockout Motor Activity - drug effects Naloxone - pharmacology Naltrexone - analogs & derivatives Naltrexone - metabolism Naltrexone - pharmacology Narcotic Antagonists - metabolism Narcotic Antagonists - pharmacology opioid receptors Opioids oprd1 gene oprk1 gene oprm gene Pain Threshold - drug effects Phenotype Receptors Receptors, Opioid, delta - deficiency Receptors, Opioid, delta - genetics Receptors, Opioid, delta - metabolism Receptors, Opioid, kappa - deficiency Receptors, Opioid, kappa - genetics Receptors, Opioid, kappa - metabolism Receptors, Opioid, mu - deficiency Receptors, Opioid, mu - genetics Receptors, Opioid, mu - metabolism Sex Characteristics Swimming
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