New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases

The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprot...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Frontiers in aging neuroscience 2021-01, Vol.13
Hauptverfasser: Boltze, Johannes, Aronowski, Jaroslaw, Badaut, Jerome, Buckwalter, Marion, Caleo, Mateo, Chopp, Michael, Dave, Kunjan, Didwischus, Nadine, Dijkhuizen, Rick, Doeppner, Thorsten, Dreier, Jens, Fouad, Karim, Gelderblom, Mathias, Gertz, Karen, Golubczyk, Dominika, Gregson, Barbara, Hamel, Edith, Hanley, Daniel, Härtig, Wolfgang, Hummel, Friedhelm, Ikhsan, Maulana, Janowski, Miroslaw, Jolkkonen, Jukka, Karuppagounder, Saravanan, Keep, Richard, Koerte, Inga, Kokaia, Zaal, Li, Peiying, Liu, Fudong, Lizasoain, Ignacio, Ludewig, Peter, Metz, Gerlinde, Montagne, Axel, Obenaus, Andre, Palumbo, Alex, Pearl, Monica, Perez-Pinzon, Miguel, Planas, Anna, Plesnila, Nikolaus, Raval, Ami, Rueger, Maria, Sansing, Lauren, Sohrabji, Farida, Stagg, Charlotte, Stetler, R. Anne, Stowe, Ann, Sun, Dandan, Taguchi, Akihiko, Tanter, Mickael, Vay, Sabine, Vemuganti, Raghu, Vivien, Denis, Walczak, Piotr, Wang, Jian, Xiong, Ye, Zille, Marietta
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title Frontiers in aging neuroscience
container_volume 13
creator Boltze, Johannes
Aronowski, Jaroslaw
Badaut, Jerome
Buckwalter, Marion
Caleo, Mateo
Chopp, Michael
Dave, Kunjan
Didwischus, Nadine
Dijkhuizen, Rick
Doeppner, Thorsten
Dreier, Jens
Fouad, Karim
Gelderblom, Mathias
Gertz, Karen
Golubczyk, Dominika
Gregson, Barbara
Hamel, Edith
Hanley, Daniel
Härtig, Wolfgang
Hummel, Friedhelm
Ikhsan, Maulana
Janowski, Miroslaw
Jolkkonen, Jukka
Karuppagounder, Saravanan
Keep, Richard
Koerte, Inga
Kokaia, Zaal
Li, Peiying
Liu, Fudong
Lizasoain, Ignacio
Ludewig, Peter
Metz, Gerlinde
Montagne, Axel
Obenaus, Andre
Palumbo, Alex
Pearl, Monica
Perez-Pinzon, Miguel
Planas, Anna
Plesnila, Nikolaus
Raval, Ami
Rueger, Maria
Sansing, Lauren
Sohrabji, Farida
Stagg, Charlotte
Stetler, R. Anne
Stowe, Ann
Sun, Dandan
Taguchi, Akihiko
Tanter, Mickael
Vay, Sabine
Vemuganti, Raghu
Vivien, Denis
Walczak, Piotr
Wang, Jian
Xiong, Ye
Zille, Marietta
description The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.
doi_str_mv 10.3389/fnagi.2021.623751
format Article
fullrecord <record><control><sourceid>hal</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_04093486v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_HAL_hal_04093486v1</sourcerecordid><originalsourceid>FETCH-hal_primary_oai_HAL_hal_04093486v13</originalsourceid><addsrcrecordid>eNqVikFLw0AQhRexYLH9Ad7mKti4m03W9ChRqaClh97DmE6Skc1GdmLEf2-FHrz6Lu_jfU-pK6MTa4v1bROw5STVqUlcau9yc6bmxjm7yqzLz__whVqKvOtjrNU6L-aq2dIXvFLdYWAZuYbnINx2o9zAdpjIwz4Sjj2FEXYY8cBtf1QYDlB6Dlyjh10c2kgiwAFKivQWhwml_vQY4YGFUEgWatagF1qe-lJdPz3uy82qQ199RO4xflcDcrW5f6l-N53ptc0KNxn7n-8P8yxStA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Boltze, Johannes ; Aronowski, Jaroslaw ; Badaut, Jerome ; Buckwalter, Marion ; Caleo, Mateo ; Chopp, Michael ; Dave, Kunjan ; Didwischus, Nadine ; Dijkhuizen, Rick ; Doeppner, Thorsten ; Dreier, Jens ; Fouad, Karim ; Gelderblom, Mathias ; Gertz, Karen ; Golubczyk, Dominika ; Gregson, Barbara ; Hamel, Edith ; Hanley, Daniel ; Härtig, Wolfgang ; Hummel, Friedhelm ; Ikhsan, Maulana ; Janowski, Miroslaw ; Jolkkonen, Jukka ; Karuppagounder, Saravanan ; Keep, Richard ; Koerte, Inga ; Kokaia, Zaal ; Li, Peiying ; Liu, Fudong ; Lizasoain, Ignacio ; Ludewig, Peter ; Metz, Gerlinde ; Montagne, Axel ; Obenaus, Andre ; Palumbo, Alex ; Pearl, Monica ; Perez-Pinzon, Miguel ; Planas, Anna ; Plesnila, Nikolaus ; Raval, Ami ; Rueger, Maria ; Sansing, Lauren ; Sohrabji, Farida ; Stagg, Charlotte ; Stetler, R. Anne ; Stowe, Ann ; Sun, Dandan ; Taguchi, Akihiko ; Tanter, Mickael ; Vay, Sabine ; Vemuganti, Raghu ; Vivien, Denis ; Walczak, Piotr ; Wang, Jian ; Xiong, Ye ; Zille, Marietta</creator><creatorcontrib>Boltze, Johannes ; Aronowski, Jaroslaw ; Badaut, Jerome ; Buckwalter, Marion ; Caleo, Mateo ; Chopp, Michael ; Dave, Kunjan ; Didwischus, Nadine ; Dijkhuizen, Rick ; Doeppner, Thorsten ; Dreier, Jens ; Fouad, Karim ; Gelderblom, Mathias ; Gertz, Karen ; Golubczyk, Dominika ; Gregson, Barbara ; Hamel, Edith ; Hanley, Daniel ; Härtig, Wolfgang ; Hummel, Friedhelm ; Ikhsan, Maulana ; Janowski, Miroslaw ; Jolkkonen, Jukka ; Karuppagounder, Saravanan ; Keep, Richard ; Koerte, Inga ; Kokaia, Zaal ; Li, Peiying ; Liu, Fudong ; Lizasoain, Ignacio ; Ludewig, Peter ; Metz, Gerlinde ; Montagne, Axel ; Obenaus, Andre ; Palumbo, Alex ; Pearl, Monica ; Perez-Pinzon, Miguel ; Planas, Anna ; Plesnila, Nikolaus ; Raval, Ami ; Rueger, Maria ; Sansing, Lauren ; Sohrabji, Farida ; Stagg, Charlotte ; Stetler, R. Anne ; Stowe, Ann ; Sun, Dandan ; Taguchi, Akihiko ; Tanter, Mickael ; Vay, Sabine ; Vemuganti, Raghu ; Vivien, Denis ; Walczak, Piotr ; Wang, Jian ; Xiong, Ye ; Zille, Marietta</creatorcontrib><description>The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.</description><identifier>ISSN: 1663-4365</identifier><identifier>EISSN: 1663-4365</identifier><identifier>DOI: 10.3389/fnagi.2021.623751</identifier><language>eng</language><publisher>Frontiers</publisher><subject>Life Sciences</subject><ispartof>Frontiers in aging neuroscience, 2021-01, Vol.13</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,866,887,27931,27932</link.rule.ids><backlink>$$Uhttps://hal.science/hal-04093486$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Boltze, Johannes</creatorcontrib><creatorcontrib>Aronowski, Jaroslaw</creatorcontrib><creatorcontrib>Badaut, Jerome</creatorcontrib><creatorcontrib>Buckwalter, Marion</creatorcontrib><creatorcontrib>Caleo, Mateo</creatorcontrib><creatorcontrib>Chopp, Michael</creatorcontrib><creatorcontrib>Dave, Kunjan</creatorcontrib><creatorcontrib>Didwischus, Nadine</creatorcontrib><creatorcontrib>Dijkhuizen, Rick</creatorcontrib><creatorcontrib>Doeppner, Thorsten</creatorcontrib><creatorcontrib>Dreier, Jens</creatorcontrib><creatorcontrib>Fouad, Karim</creatorcontrib><creatorcontrib>Gelderblom, Mathias</creatorcontrib><creatorcontrib>Gertz, Karen</creatorcontrib><creatorcontrib>Golubczyk, Dominika</creatorcontrib><creatorcontrib>Gregson, Barbara</creatorcontrib><creatorcontrib>Hamel, Edith</creatorcontrib><creatorcontrib>Hanley, Daniel</creatorcontrib><creatorcontrib>Härtig, Wolfgang</creatorcontrib><creatorcontrib>Hummel, Friedhelm</creatorcontrib><creatorcontrib>Ikhsan, Maulana</creatorcontrib><creatorcontrib>Janowski, Miroslaw</creatorcontrib><creatorcontrib>Jolkkonen, Jukka</creatorcontrib><creatorcontrib>Karuppagounder, Saravanan</creatorcontrib><creatorcontrib>Keep, Richard</creatorcontrib><creatorcontrib>Koerte, Inga</creatorcontrib><creatorcontrib>Kokaia, Zaal</creatorcontrib><creatorcontrib>Li, Peiying</creatorcontrib><creatorcontrib>Liu, Fudong</creatorcontrib><creatorcontrib>Lizasoain, Ignacio</creatorcontrib><creatorcontrib>Ludewig, Peter</creatorcontrib><creatorcontrib>Metz, Gerlinde</creatorcontrib><creatorcontrib>Montagne, Axel</creatorcontrib><creatorcontrib>Obenaus, Andre</creatorcontrib><creatorcontrib>Palumbo, Alex</creatorcontrib><creatorcontrib>Pearl, Monica</creatorcontrib><creatorcontrib>Perez-Pinzon, Miguel</creatorcontrib><creatorcontrib>Planas, Anna</creatorcontrib><creatorcontrib>Plesnila, Nikolaus</creatorcontrib><creatorcontrib>Raval, Ami</creatorcontrib><creatorcontrib>Rueger, Maria</creatorcontrib><creatorcontrib>Sansing, Lauren</creatorcontrib><creatorcontrib>Sohrabji, Farida</creatorcontrib><creatorcontrib>Stagg, Charlotte</creatorcontrib><creatorcontrib>Stetler, R. Anne</creatorcontrib><creatorcontrib>Stowe, Ann</creatorcontrib><creatorcontrib>Sun, Dandan</creatorcontrib><creatorcontrib>Taguchi, Akihiko</creatorcontrib><creatorcontrib>Tanter, Mickael</creatorcontrib><creatorcontrib>Vay, Sabine</creatorcontrib><creatorcontrib>Vemuganti, Raghu</creatorcontrib><creatorcontrib>Vivien, Denis</creatorcontrib><creatorcontrib>Walczak, Piotr</creatorcontrib><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Xiong, Ye</creatorcontrib><creatorcontrib>Zille, Marietta</creatorcontrib><title>New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases</title><title>Frontiers in aging neuroscience</title><description>The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.</description><subject>Life Sciences</subject><issn>1663-4365</issn><issn>1663-4365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqVikFLw0AQhRexYLH9Ad7mKti4m03W9ChRqaClh97DmE6Skc1GdmLEf2-FHrz6Lu_jfU-pK6MTa4v1bROw5STVqUlcau9yc6bmxjm7yqzLz__whVqKvOtjrNU6L-aq2dIXvFLdYWAZuYbnINx2o9zAdpjIwz4Sjj2FEXYY8cBtf1QYDlB6Dlyjh10c2kgiwAFKivQWhwml_vQY4YGFUEgWatagF1qe-lJdPz3uy82qQ199RO4xflcDcrW5f6l-N53ptc0KNxn7n-8P8yxStA</recordid><startdate>20210128</startdate><enddate>20210128</enddate><creator>Boltze, Johannes</creator><creator>Aronowski, Jaroslaw</creator><creator>Badaut, Jerome</creator><creator>Buckwalter, Marion</creator><creator>Caleo, Mateo</creator><creator>Chopp, Michael</creator><creator>Dave, Kunjan</creator><creator>Didwischus, Nadine</creator><creator>Dijkhuizen, Rick</creator><creator>Doeppner, Thorsten</creator><creator>Dreier, Jens</creator><creator>Fouad, Karim</creator><creator>Gelderblom, Mathias</creator><creator>Gertz, Karen</creator><creator>Golubczyk, Dominika</creator><creator>Gregson, Barbara</creator><creator>Hamel, Edith</creator><creator>Hanley, Daniel</creator><creator>Härtig, Wolfgang</creator><creator>Hummel, Friedhelm</creator><creator>Ikhsan, Maulana</creator><creator>Janowski, Miroslaw</creator><creator>Jolkkonen, Jukka</creator><creator>Karuppagounder, Saravanan</creator><creator>Keep, Richard</creator><creator>Koerte, Inga</creator><creator>Kokaia, Zaal</creator><creator>Li, Peiying</creator><creator>Liu, Fudong</creator><creator>Lizasoain, Ignacio</creator><creator>Ludewig, Peter</creator><creator>Metz, Gerlinde</creator><creator>Montagne, Axel</creator><creator>Obenaus, Andre</creator><creator>Palumbo, Alex</creator><creator>Pearl, Monica</creator><creator>Perez-Pinzon, Miguel</creator><creator>Planas, Anna</creator><creator>Plesnila, Nikolaus</creator><creator>Raval, Ami</creator><creator>Rueger, Maria</creator><creator>Sansing, Lauren</creator><creator>Sohrabji, Farida</creator><creator>Stagg, Charlotte</creator><creator>Stetler, R. Anne</creator><creator>Stowe, Ann</creator><creator>Sun, Dandan</creator><creator>Taguchi, Akihiko</creator><creator>Tanter, Mickael</creator><creator>Vay, Sabine</creator><creator>Vemuganti, Raghu</creator><creator>Vivien, Denis</creator><creator>Walczak, Piotr</creator><creator>Wang, Jian</creator><creator>Xiong, Ye</creator><creator>Zille, Marietta</creator><general>Frontiers</general><scope>1XC</scope></search><sort><creationdate>20210128</creationdate><title>New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases</title><author>Boltze, Johannes ; Aronowski, Jaroslaw ; Badaut, Jerome ; Buckwalter, Marion ; Caleo, Mateo ; Chopp, Michael ; Dave, Kunjan ; Didwischus, Nadine ; Dijkhuizen, Rick ; Doeppner, Thorsten ; Dreier, Jens ; Fouad, Karim ; Gelderblom, Mathias ; Gertz, Karen ; Golubczyk, Dominika ; Gregson, Barbara ; Hamel, Edith ; Hanley, Daniel ; Härtig, Wolfgang ; Hummel, Friedhelm ; Ikhsan, Maulana ; Janowski, Miroslaw ; Jolkkonen, Jukka ; Karuppagounder, Saravanan ; Keep, Richard ; Koerte, Inga ; Kokaia, Zaal ; Li, Peiying ; Liu, Fudong ; Lizasoain, Ignacio ; Ludewig, Peter ; Metz, Gerlinde ; Montagne, Axel ; Obenaus, Andre ; Palumbo, Alex ; Pearl, Monica ; Perez-Pinzon, Miguel ; Planas, Anna ; Plesnila, Nikolaus ; Raval, Ami ; Rueger, Maria ; Sansing, Lauren ; Sohrabji, Farida ; Stagg, Charlotte ; Stetler, R. Anne ; Stowe, Ann ; Sun, Dandan ; Taguchi, Akihiko ; Tanter, Mickael ; Vay, Sabine ; Vemuganti, Raghu ; Vivien, Denis ; Walczak, Piotr ; Wang, Jian ; Xiong, Ye ; Zille, Marietta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-hal_primary_oai_HAL_hal_04093486v13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Life Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boltze, Johannes</creatorcontrib><creatorcontrib>Aronowski, Jaroslaw</creatorcontrib><creatorcontrib>Badaut, Jerome</creatorcontrib><creatorcontrib>Buckwalter, Marion</creatorcontrib><creatorcontrib>Caleo, Mateo</creatorcontrib><creatorcontrib>Chopp, Michael</creatorcontrib><creatorcontrib>Dave, Kunjan</creatorcontrib><creatorcontrib>Didwischus, Nadine</creatorcontrib><creatorcontrib>Dijkhuizen, Rick</creatorcontrib><creatorcontrib>Doeppner, Thorsten</creatorcontrib><creatorcontrib>Dreier, Jens</creatorcontrib><creatorcontrib>Fouad, Karim</creatorcontrib><creatorcontrib>Gelderblom, Mathias</creatorcontrib><creatorcontrib>Gertz, Karen</creatorcontrib><creatorcontrib>Golubczyk, Dominika</creatorcontrib><creatorcontrib>Gregson, Barbara</creatorcontrib><creatorcontrib>Hamel, Edith</creatorcontrib><creatorcontrib>Hanley, Daniel</creatorcontrib><creatorcontrib>Härtig, Wolfgang</creatorcontrib><creatorcontrib>Hummel, Friedhelm</creatorcontrib><creatorcontrib>Ikhsan, Maulana</creatorcontrib><creatorcontrib>Janowski, Miroslaw</creatorcontrib><creatorcontrib>Jolkkonen, Jukka</creatorcontrib><creatorcontrib>Karuppagounder, Saravanan</creatorcontrib><creatorcontrib>Keep, Richard</creatorcontrib><creatorcontrib>Koerte, Inga</creatorcontrib><creatorcontrib>Kokaia, Zaal</creatorcontrib><creatorcontrib>Li, Peiying</creatorcontrib><creatorcontrib>Liu, Fudong</creatorcontrib><creatorcontrib>Lizasoain, Ignacio</creatorcontrib><creatorcontrib>Ludewig, Peter</creatorcontrib><creatorcontrib>Metz, Gerlinde</creatorcontrib><creatorcontrib>Montagne, Axel</creatorcontrib><creatorcontrib>Obenaus, Andre</creatorcontrib><creatorcontrib>Palumbo, Alex</creatorcontrib><creatorcontrib>Pearl, Monica</creatorcontrib><creatorcontrib>Perez-Pinzon, Miguel</creatorcontrib><creatorcontrib>Planas, Anna</creatorcontrib><creatorcontrib>Plesnila, Nikolaus</creatorcontrib><creatorcontrib>Raval, Ami</creatorcontrib><creatorcontrib>Rueger, Maria</creatorcontrib><creatorcontrib>Sansing, Lauren</creatorcontrib><creatorcontrib>Sohrabji, Farida</creatorcontrib><creatorcontrib>Stagg, Charlotte</creatorcontrib><creatorcontrib>Stetler, R. Anne</creatorcontrib><creatorcontrib>Stowe, Ann</creatorcontrib><creatorcontrib>Sun, Dandan</creatorcontrib><creatorcontrib>Taguchi, Akihiko</creatorcontrib><creatorcontrib>Tanter, Mickael</creatorcontrib><creatorcontrib>Vay, Sabine</creatorcontrib><creatorcontrib>Vemuganti, Raghu</creatorcontrib><creatorcontrib>Vivien, Denis</creatorcontrib><creatorcontrib>Walczak, Piotr</creatorcontrib><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Xiong, Ye</creatorcontrib><creatorcontrib>Zille, Marietta</creatorcontrib><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Frontiers in aging neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boltze, Johannes</au><au>Aronowski, Jaroslaw</au><au>Badaut, Jerome</au><au>Buckwalter, Marion</au><au>Caleo, Mateo</au><au>Chopp, Michael</au><au>Dave, Kunjan</au><au>Didwischus, Nadine</au><au>Dijkhuizen, Rick</au><au>Doeppner, Thorsten</au><au>Dreier, Jens</au><au>Fouad, Karim</au><au>Gelderblom, Mathias</au><au>Gertz, Karen</au><au>Golubczyk, Dominika</au><au>Gregson, Barbara</au><au>Hamel, Edith</au><au>Hanley, Daniel</au><au>Härtig, Wolfgang</au><au>Hummel, Friedhelm</au><au>Ikhsan, Maulana</au><au>Janowski, Miroslaw</au><au>Jolkkonen, Jukka</au><au>Karuppagounder, Saravanan</au><au>Keep, Richard</au><au>Koerte, Inga</au><au>Kokaia, Zaal</au><au>Li, Peiying</au><au>Liu, Fudong</au><au>Lizasoain, Ignacio</au><au>Ludewig, Peter</au><au>Metz, Gerlinde</au><au>Montagne, Axel</au><au>Obenaus, Andre</au><au>Palumbo, Alex</au><au>Pearl, Monica</au><au>Perez-Pinzon, Miguel</au><au>Planas, Anna</au><au>Plesnila, Nikolaus</au><au>Raval, Ami</au><au>Rueger, Maria</au><au>Sansing, Lauren</au><au>Sohrabji, Farida</au><au>Stagg, Charlotte</au><au>Stetler, R. Anne</au><au>Stowe, Ann</au><au>Sun, Dandan</au><au>Taguchi, Akihiko</au><au>Tanter, Mickael</au><au>Vay, Sabine</au><au>Vemuganti, Raghu</au><au>Vivien, Denis</au><au>Walczak, Piotr</au><au>Wang, Jian</au><au>Xiong, Ye</au><au>Zille, Marietta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases</atitle><jtitle>Frontiers in aging neuroscience</jtitle><date>2021-01-28</date><risdate>2021</risdate><volume>13</volume><issn>1663-4365</issn><eissn>1663-4365</eissn><abstract>The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.</abstract><pub>Frontiers</pub><doi>10.3389/fnagi.2021.623751</doi></addata></record>
fulltext fulltext
identifier ISSN: 1663-4365
ispartof Frontiers in aging neuroscience, 2021-01, Vol.13
issn 1663-4365
1663-4365
language eng
recordid cdi_hal_primary_oai_HAL_hal_04093486v1
source DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central
subjects Life Sciences
title New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T20%3A55%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-hal&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20Mechanistic%20Insights,%20Novel%20Treatment%20Paradigms,%20and%20Clinical%20Progress%20in%20Cerebrovascular%20Diseases&rft.jtitle=Frontiers%20in%20aging%20neuroscience&rft.au=Boltze,%20Johannes&rft.date=2021-01-28&rft.volume=13&rft.issn=1663-4365&rft.eissn=1663-4365&rft_id=info:doi/10.3389/fnagi.2021.623751&rft_dat=%3Chal%3Eoai_HAL_hal_04093486v1%3C/hal%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true