Structural insights into interactions of new polymeric (μ–oxo) bridged Cu(II) complexes of taurine with yeast tRNA by spectroscopic and computational approaches and its application towards chemoresistant cancer lines

RNA-targeted drugs are considered as safe treatment option for the cure of many chronic diseases preventing off-targeted delivery and acute toxic manifestations. FDA has approved many such RNA therapies in different phases of clinical trials, validating their use for the treatment of various chronic...

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Veröffentlicht in:	International journal of biological macromolecules 2023-06, Vol.240, p.124429-124429, Article 124429
Hauptverfasser:	Zehra, Siffeen, Khan, Huzaifa Yasir, Roisnel, Thierry, Tabassum, Sartaj, Arjmand, Farukh
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Binding modes Chemical Sciences Coordination Complexes - chemistry Copper - chemistry Cu(II) complexes Cytotoxicity DNA - chemistry Drug-RNA interaction EtBr displacement Medicinal Chemistry Neoplasms RNA RNA, Transfer Saccharomyces cerevisiae - metabolism
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