Clear cell tumor with melanocytic differentiation and MITF-CREM translocation: a novel entity similar to clear cell sarcoma
The presence of melanocytic differentiation in tumors of non-melanocyte origin is uncommon and is typically associated with the overexpression of MITF, the master regulator of melanin synthesis, or another member of the MIT/TFE3 family. In clear cell sarcoma, the presence of either an EWSR1-ATF1 or...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2021-10, Vol.479 (4), p.841-846 |
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| creator | de la Fouchardiere, Arnaud Pissaloux, Daniel Tirode, Franck Hanna, John |
| description | The presence of melanocytic differentiation in tumors of non-melanocyte origin is uncommon and is typically associated with the overexpression of MITF, the master regulator of melanin synthesis, or another member of the MIT/TFE3 family. In clear cell sarcoma, the presence of either an EWSR1-ATF1 or EWSR1-CREB1 translocation-derived fusion protein is thought to drive melanocytic differentiation by directly stimulating the expression of MITF. Here, we describe a clear cell neoplasm with melanocytic differentiation that is characterized by a novel
MITF-CREM
gene fusion. CREM is the third member of the ATF1/CREB1/CREM family, and the nature of the MITF-CREM fusion appears analogous to the EWSR1-ATF1 and EWSR1-CREB1 fusions. Thus, this MITF-CREM-rearranged clear cell tumor represents a novel entity with morphologic, immunohistochemical, and molecular similarity to clear cell sarcoma. |
| doi_str_mv | 10.1007/s00428-021-03027-3 |
| format | Article |
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MITF-CREM
gene fusion. CREM is the third member of the ATF1/CREB1/CREM family, and the nature of the MITF-CREM fusion appears analogous to the EWSR1-ATF1 and EWSR1-CREB1 fusions. Thus, this MITF-CREM-rearranged clear cell tumor represents a novel entity with morphologic, immunohistochemical, and molecular similarity to clear cell sarcoma.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-021-03027-3</identifier><identifier>PMID: 33462743</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Brief Report ; Cancer ; Cell differentiation ; Cyclic AMP response element modulator ; Differentiation ; FLI-1 protein ; Fusion protein ; Gene fusion ; Life Sciences ; Medicine ; Medicine & Public Health ; Melanin ; Microphthalmia-associated transcription factor ; Pathology ; Protein transport ; Sarcoma ; Translocation ; Tumors</subject><ispartof>Virchows Archiv : an international journal of pathology, 2021-10, Vol.479 (4), p.841-846</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-5caec4ad07e87828d71c590a94f71fa4833741b8c8faffea38b5b215c87a194b3</citedby><cites>FETCH-LOGICAL-c409t-5caec4ad07e87828d71c590a94f71fa4833741b8c8faffea38b5b215c87a194b3</cites><orcidid>0000-0003-2964-1058 ; 0000-0003-4731-7817 ; 0000-0003-2251-8241</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00428-021-03027-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00428-021-03027-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33462743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://cnrs.hal.science/hal-04064765$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>de la Fouchardiere, Arnaud</creatorcontrib><creatorcontrib>Pissaloux, Daniel</creatorcontrib><creatorcontrib>Tirode, Franck</creatorcontrib><creatorcontrib>Hanna, John</creatorcontrib><title>Clear cell tumor with melanocytic differentiation and MITF-CREM translocation: a novel entity similar to clear cell sarcoma</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>The presence of melanocytic differentiation in tumors of non-melanocyte origin is uncommon and is typically associated with the overexpression of MITF, the master regulator of melanin synthesis, or another member of the MIT/TFE3 family. In clear cell sarcoma, the presence of either an EWSR1-ATF1 or EWSR1-CREB1 translocation-derived fusion protein is thought to drive melanocytic differentiation by directly stimulating the expression of MITF. Here, we describe a clear cell neoplasm with melanocytic differentiation that is characterized by a novel
MITF-CREM
gene fusion. CREM is the third member of the ATF1/CREB1/CREM family, and the nature of the MITF-CREM fusion appears analogous to the EWSR1-ATF1 and EWSR1-CREB1 fusions. Thus, this MITF-CREM-rearranged clear cell tumor represents a novel entity with morphologic, immunohistochemical, and molecular similarity to clear cell sarcoma.</description><subject>Brief Report</subject><subject>Cancer</subject><subject>Cell differentiation</subject><subject>Cyclic AMP response element modulator</subject><subject>Differentiation</subject><subject>FLI-1 protein</subject><subject>Fusion protein</subject><subject>Gene fusion</subject><subject>Life Sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanin</subject><subject>Microphthalmia-associated transcription factor</subject><subject>Pathology</subject><subject>Protein transport</subject><subject>Sarcoma</subject><subject>Translocation</subject><subject>Tumors</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtr3TAQhUVpaG6T_oEuiqCbduFUT0vuLlySJnBDoSRrMZblRsG2UklOuPTPVzfOA7LoamDmmzNnOAh9pOSIEqK-JUIE0xVhtCKcMFXxN2hFBWcV40S9RSvSCFnVnKp99D6lG1JITet3aJ9zUTMl-Ar9XQ8OIrZuGHCexxDxvc_XeHQDTMFus7e4833vopuyh-zDhGHq8MX55Wm1_nVygXOEKQ3BPsy-Y8BTuHMD3uF5i5Mf_VD0c8D25VCCaMMIh2ivhyG5D4_1AF2dnlyuz6rNzx_n6-NNZQVpciUtOCugI8pppZnuFLWyIdCIXtEehOZcCdpqq3soToHrVraMSqsV0Ea0_AB9XXSvYTC30Y8QtyaAN2fHG7PrEUFqoWp5Rwv7ZWFvY_gzu5TN6NPONEwuzMkwoRoiuNB1QT-_Qm_CHKfyiWFS00ZyWctCsYWyMaQUXf_sgBKzi9EsMZoSjnmI0fCy9OlRem5H1z2vPOVWAL4AqYym3y6-3P6P7D-G8KeA</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>de la Fouchardiere, Arnaud</creator><creator>Pissaloux, Daniel</creator><creator>Tirode, Franck</creator><creator>Hanna, John</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-2964-1058</orcidid><orcidid>https://orcid.org/0000-0003-4731-7817</orcidid><orcidid>https://orcid.org/0000-0003-2251-8241</orcidid></search><sort><creationdate>20211001</creationdate><title>Clear cell tumor with melanocytic differentiation and MITF-CREM translocation: a novel entity similar to clear cell sarcoma</title><author>de la Fouchardiere, Arnaud ; Pissaloux, Daniel ; Tirode, Franck ; Hanna, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-5caec4ad07e87828d71c590a94f71fa4833741b8c8faffea38b5b215c87a194b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Brief Report</topic><topic>Cancer</topic><topic>Cell differentiation</topic><topic>Cyclic AMP response element modulator</topic><topic>Differentiation</topic><topic>FLI-1 protein</topic><topic>Fusion protein</topic><topic>Gene fusion</topic><topic>Life Sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melanin</topic><topic>Microphthalmia-associated transcription factor</topic><topic>Pathology</topic><topic>Protein transport</topic><topic>Sarcoma</topic><topic>Translocation</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de la Fouchardiere, Arnaud</creatorcontrib><creatorcontrib>Pissaloux, Daniel</creatorcontrib><creatorcontrib>Tirode, Franck</creatorcontrib><creatorcontrib>Hanna, John</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de la Fouchardiere, Arnaud</au><au>Pissaloux, Daniel</au><au>Tirode, Franck</au><au>Hanna, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clear cell tumor with melanocytic differentiation and MITF-CREM translocation: a novel entity similar to clear cell sarcoma</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><stitle>Virchows Arch</stitle><addtitle>Virchows Arch</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>479</volume><issue>4</issue><spage>841</spage><epage>846</epage><pages>841-846</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>The presence of melanocytic differentiation in tumors of non-melanocyte origin is uncommon and is typically associated with the overexpression of MITF, the master regulator of melanin synthesis, or another member of the MIT/TFE3 family. In clear cell sarcoma, the presence of either an EWSR1-ATF1 or EWSR1-CREB1 translocation-derived fusion protein is thought to drive melanocytic differentiation by directly stimulating the expression of MITF. Here, we describe a clear cell neoplasm with melanocytic differentiation that is characterized by a novel
MITF-CREM
gene fusion. CREM is the third member of the ATF1/CREB1/CREM family, and the nature of the MITF-CREM fusion appears analogous to the EWSR1-ATF1 and EWSR1-CREB1 fusions. Thus, this MITF-CREM-rearranged clear cell tumor represents a novel entity with morphologic, immunohistochemical, and molecular similarity to clear cell sarcoma.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33462743</pmid><doi>10.1007/s00428-021-03027-3</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2964-1058</orcidid><orcidid>https://orcid.org/0000-0003-4731-7817</orcidid><orcidid>https://orcid.org/0000-0003-2251-8241</orcidid></addata></record> |
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| ispartof | Virchows Archiv : an international journal of pathology, 2021-10, Vol.479 (4), p.841-846 |
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| language | eng |
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| subjects | Brief Report Cancer Cell differentiation Cyclic AMP response element modulator Differentiation FLI-1 protein Fusion protein Gene fusion Life Sciences Medicine Medicine & Public Health Melanin Microphthalmia-associated transcription factor Pathology Protein transport Sarcoma Translocation Tumors |
| title | Clear cell tumor with melanocytic differentiation and MITF-CREM translocation: a novel entity similar to clear cell sarcoma |
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