Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice

The Jak2V617F mutation is found in most classical BCR/ABL-negative myeloproliferative neoplasms (MPNs). Usually, heterozygosity of the mutation is associated with essential thrombocythemia (ET) and homozygosity with polycythemia vera (PV). Retrovirally transduced or transgenic animal models have sho...

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Veröffentlicht in:	Blood 2010-08, Vol.116 (5), p.783-787
Hauptverfasser:	Marty, Caroline, Lacout, Catherine, Martin, Antoine, Hasan, Salma, Jacquot, Sylvie, Birling, Marie-Christine, Vainchenker, William, Villeval, Jean-Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animal biology Animals Biological and medical sciences Bone Marrow - pathology Cell Lineage Crosses, Genetic Gene Knock-In Techniques Hematologic and hematopoietic diseases Heterozygote Humans Hyperplasia Janus Kinase 2 - genetics Janus Kinase 2 - physiology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Life Sciences Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Mutation, Missense Myeloproliferative Disorders - enzymology Myeloproliferative Disorders - etiology Myeloproliferative Disorders - genetics Point Mutation Polycythemia Vera - enzymology Polycythemia Vera - genetics Primary Myelofibrosis - enzymology Primary Myelofibrosis - etiology Primary Myelofibrosis - genetics Spleen - pathology Thrombocythemia, Essential - enzymology Thrombocythemia, Essential - genetics
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