Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells

Chloride secretion by airway epithelial cells is primordial for water and ion homeostasis and airways surface prevention of infections. This secretion is impaired in several human diseases, including cystic fibrosis, a genetic pathology due to gene mutations leading to chloride channel defects. A po...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2021-02, Vol.320 (2), p.L205-L219
Hauptverfasser:	Grebert, Chloé, Becq, Frédéric, Vandebrouck, Clarisse
Format:	Artikel
Sprache:	eng
Schlagworte:	Bronchi - cytology Bronchi - metabolism Cell Line Chlorides - metabolism Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Epithelial Cells - cytology Epithelial Cells - metabolism Humans Isoenzymes - genetics Isoenzymes - metabolism Life Sciences Membrane Potentials Type C Phospholipases - genetics Type C Phospholipases - metabolism
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