In vivo targeting and multimodal imaging of cerebral amyloid-β aggregates using hybrid GdF 3 nanoparticles
To propose a new multimodal imaging agent targeting amyloid-β (Aβ) plaques in Alzheimer's disease. A new generation of hybrid contrast agents, based on gadolinium fluoride nanoparticles grafted with a pentameric luminescent-conjugated polythiophene, was designed, extensively characterized and e...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2022-12, Vol.17 (29), p.2173-2187 |
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| creator | Lerouge, Frédéric Ong, Elodie Rositi, Hugo Mpambani, Francis Berner, Lise-Prune Bolbos, Radu Olivier, Cécile Peyrin, Françoise Apputukan, Vinu K Monnereau, Cyrille Andraud, Chantal Chaput, Frederic Berthezène, Yves Braun, Bettina Jucker, Mathias Åslund, Andreas Ko Nyström, Sofie Hammarström, Per R Nilsson, K Peter Lindgren, Mikael Wiart, Marlène Chauveau, Fabien Parola, Stephane |
| description | To propose a new multimodal imaging agent targeting amyloid-β (Aβ) plaques in Alzheimer's disease.
A new generation of hybrid contrast agents, based on gadolinium fluoride nanoparticles grafted with a pentameric luminescent-conjugated polythiophene, was designed, extensively characterized and evaluated in animal models of Alzheimer's disease through MRI, two-photon microscopy and synchrotron x-ray phase-contrast imaging.
Two different grafting densities of luminescent-conjugated polythiophene were achieved while preserving colloidal stability and fluorescent properties, and without affecting biodistribution.
brain uptake was dependent on the blood-brain barrier status. Nevertheless, multimodal imaging showed successful Aβ targeting in both transgenic mice and Aβ fibril-injected rats. |
| doi_str_mv | 10.2217/nnm-2022-0252 |
| format | Article |
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A new generation of hybrid contrast agents, based on gadolinium fluoride nanoparticles grafted with a pentameric luminescent-conjugated polythiophene, was designed, extensively characterized and evaluated in animal models of Alzheimer's disease through MRI, two-photon microscopy and synchrotron x-ray phase-contrast imaging.
Two different grafting densities of luminescent-conjugated polythiophene were achieved while preserving colloidal stability and fluorescent properties, and without affecting biodistribution.
brain uptake was dependent on the blood-brain barrier status. Nevertheless, multimodal imaging showed successful Aβ targeting in both transgenic mice and Aβ fibril-injected rats.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2022-0252</identifier><identifier>PMID: 36927004</identifier><language>eng</language><publisher>England: Future Medicine</publisher><subject>Alzheimer Disease - diagnostic imaging ; Amyloid beta-Peptides - metabolism ; Animals ; Bioengineering ; Brain - diagnostic imaging ; Brain - metabolism ; Disease Models, Animal ; Imaging ; Life Sciences ; Mice ; Mice, Transgenic ; Multimodal Imaging ; Nanoparticles ; Neurobiology ; Neurons and Cognition ; Rats ; Tissue Distribution</subject><ispartof>Nanomedicine (London, England), 2022-12, Vol.17 (29), p.2173-2187</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1782-b487b74ab40c73d44da123d7700391909b0c554ea5fb2b3c8bdf47f10e0df1023</citedby><cites>FETCH-LOGICAL-c1782-b487b74ab40c73d44da123d7700391909b0c554ea5fb2b3c8bdf47f10e0df1023</cites><orcidid>0000-0002-4177-741X ; 0000-0001-6649-7871 ; 0000-0003-0326-7002 ; 0000-0001-5827-3587 ; 0000-0002-8928-2416 ; 0000-0002-4303-4783 ; 0000-0001-9045-1072 ; 0000-0001-5222-9307 ; 0000-0002-9483-0683 ; 0000-0003-3360-708X ; 0000-0002-5264-2027 ; 0000-0001-6725-7861 ; 0000-0001-7560-988X ; 0000-0001-7127-4250 ; 0000-0002-1988-3435 ; 0000-0002-3990-9241 ; 0000-0002-4623-3227 ; 0000-0002-5315-8675</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36927004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04038718$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lerouge, Frédéric</creatorcontrib><creatorcontrib>Ong, Elodie</creatorcontrib><creatorcontrib>Rositi, Hugo</creatorcontrib><creatorcontrib>Mpambani, Francis</creatorcontrib><creatorcontrib>Berner, Lise-Prune</creatorcontrib><creatorcontrib>Bolbos, Radu</creatorcontrib><creatorcontrib>Olivier, Cécile</creatorcontrib><creatorcontrib>Peyrin, Françoise</creatorcontrib><creatorcontrib>Apputukan, Vinu K</creatorcontrib><creatorcontrib>Monnereau, Cyrille</creatorcontrib><creatorcontrib>Andraud, Chantal</creatorcontrib><creatorcontrib>Chaput, Frederic</creatorcontrib><creatorcontrib>Berthezène, Yves</creatorcontrib><creatorcontrib>Braun, Bettina</creatorcontrib><creatorcontrib>Jucker, Mathias</creatorcontrib><creatorcontrib>Åslund, Andreas Ko</creatorcontrib><creatorcontrib>Nyström, Sofie</creatorcontrib><creatorcontrib>Hammarström, Per</creatorcontrib><creatorcontrib>R Nilsson, K Peter</creatorcontrib><creatorcontrib>Lindgren, Mikael</creatorcontrib><creatorcontrib>Wiart, Marlène</creatorcontrib><creatorcontrib>Chauveau, Fabien</creatorcontrib><creatorcontrib>Parola, Stephane</creatorcontrib><title>In vivo targeting and multimodal imaging of cerebral amyloid-β aggregates using hybrid GdF 3 nanoparticles</title><title>Nanomedicine (London, England)</title><addtitle>Nanomedicine (Lond)</addtitle><description>To propose a new multimodal imaging agent targeting amyloid-β (Aβ) plaques in Alzheimer's disease.
A new generation of hybrid contrast agents, based on gadolinium fluoride nanoparticles grafted with a pentameric luminescent-conjugated polythiophene, was designed, extensively characterized and evaluated in animal models of Alzheimer's disease through MRI, two-photon microscopy and synchrotron x-ray phase-contrast imaging.
Two different grafting densities of luminescent-conjugated polythiophene were achieved while preserving colloidal stability and fluorescent properties, and without affecting biodistribution.
brain uptake was dependent on the blood-brain barrier status. Nevertheless, multimodal imaging showed successful Aβ targeting in both transgenic mice and Aβ fibril-injected rats.</description><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Animals</subject><subject>Bioengineering</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Disease Models, Animal</subject><subject>Imaging</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Multimodal Imaging</subject><subject>Nanoparticles</subject><subject>Neurobiology</subject><subject>Neurons and Cognition</subject><subject>Rats</subject><subject>Tissue Distribution</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EoqWwZIu8ZWEYP1I7y6qiD6kSG1hbduykhjwqJ63U3-JD-CYSCt14rKszo5mD0D2FJ8aofK7rijBgjABL2AUaUykUmaZTfvn75yRRKh2hm7b9AEgUo3CNRnyaMgkgxuhzXeNDODS4M7HwXagLbGqHq33ZhapxpsShMsUQNznOfPQ29pmpjmUTHPn-wqYooi9M51u8bwdue7QxOLx0C8xxbepmZ2IXstK3t-gqN2Xr7_7qBL0vXt7mK7J5Xa7nsw3JqFSMWKGklcJYAZnkTghnKONO9gvzlKaQWsiSRHiT5JZZninrciFzCh5c_zI-QY-nuVtT6l3sD4hH3ZigV7ONHjIQwJWk6kB7lpzYLDZtG31-bqCgB8G6F6wHwXoQ3PMPJ363t5V3Z_rfKP8Bml93PQ</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Lerouge, Frédéric</creator><creator>Ong, Elodie</creator><creator>Rositi, Hugo</creator><creator>Mpambani, Francis</creator><creator>Berner, Lise-Prune</creator><creator>Bolbos, Radu</creator><creator>Olivier, Cécile</creator><creator>Peyrin, Françoise</creator><creator>Apputukan, Vinu K</creator><creator>Monnereau, Cyrille</creator><creator>Andraud, Chantal</creator><creator>Chaput, Frederic</creator><creator>Berthezène, Yves</creator><creator>Braun, Bettina</creator><creator>Jucker, Mathias</creator><creator>Åslund, Andreas Ko</creator><creator>Nyström, Sofie</creator><creator>Hammarström, Per</creator><creator>R Nilsson, K Peter</creator><creator>Lindgren, Mikael</creator><creator>Wiart, Marlène</creator><creator>Chauveau, Fabien</creator><creator>Parola, Stephane</creator><general>Future Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-4177-741X</orcidid><orcidid>https://orcid.org/0000-0001-6649-7871</orcidid><orcidid>https://orcid.org/0000-0003-0326-7002</orcidid><orcidid>https://orcid.org/0000-0001-5827-3587</orcidid><orcidid>https://orcid.org/0000-0002-8928-2416</orcidid><orcidid>https://orcid.org/0000-0002-4303-4783</orcidid><orcidid>https://orcid.org/0000-0001-9045-1072</orcidid><orcidid>https://orcid.org/0000-0001-5222-9307</orcidid><orcidid>https://orcid.org/0000-0002-9483-0683</orcidid><orcidid>https://orcid.org/0000-0003-3360-708X</orcidid><orcidid>https://orcid.org/0000-0002-5264-2027</orcidid><orcidid>https://orcid.org/0000-0001-6725-7861</orcidid><orcidid>https://orcid.org/0000-0001-7560-988X</orcidid><orcidid>https://orcid.org/0000-0001-7127-4250</orcidid><orcidid>https://orcid.org/0000-0002-1988-3435</orcidid><orcidid>https://orcid.org/0000-0002-3990-9241</orcidid><orcidid>https://orcid.org/0000-0002-4623-3227</orcidid><orcidid>https://orcid.org/0000-0002-5315-8675</orcidid></search><sort><creationdate>202212</creationdate><title>In vivo targeting and multimodal imaging of cerebral amyloid-β aggregates using hybrid GdF 3 nanoparticles</title><author>Lerouge, Frédéric ; 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A new generation of hybrid contrast agents, based on gadolinium fluoride nanoparticles grafted with a pentameric luminescent-conjugated polythiophene, was designed, extensively characterized and evaluated in animal models of Alzheimer's disease through MRI, two-photon microscopy and synchrotron x-ray phase-contrast imaging.
Two different grafting densities of luminescent-conjugated polythiophene were achieved while preserving colloidal stability and fluorescent properties, and without affecting biodistribution.
brain uptake was dependent on the blood-brain barrier status. Nevertheless, multimodal imaging showed successful Aβ targeting in both transgenic mice and Aβ fibril-injected rats.</abstract><cop>England</cop><pub>Future Medicine</pub><pmid>36927004</pmid><doi>10.2217/nnm-2022-0252</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-4177-741X</orcidid><orcidid>https://orcid.org/0000-0001-6649-7871</orcidid><orcidid>https://orcid.org/0000-0003-0326-7002</orcidid><orcidid>https://orcid.org/0000-0001-5827-3587</orcidid><orcidid>https://orcid.org/0000-0002-8928-2416</orcidid><orcidid>https://orcid.org/0000-0002-4303-4783</orcidid><orcidid>https://orcid.org/0000-0001-9045-1072</orcidid><orcidid>https://orcid.org/0000-0001-5222-9307</orcidid><orcidid>https://orcid.org/0000-0002-9483-0683</orcidid><orcidid>https://orcid.org/0000-0003-3360-708X</orcidid><orcidid>https://orcid.org/0000-0002-5264-2027</orcidid><orcidid>https://orcid.org/0000-0001-6725-7861</orcidid><orcidid>https://orcid.org/0000-0001-7560-988X</orcidid><orcidid>https://orcid.org/0000-0001-7127-4250</orcidid><orcidid>https://orcid.org/0000-0002-1988-3435</orcidid><orcidid>https://orcid.org/0000-0002-3990-9241</orcidid><orcidid>https://orcid.org/0000-0002-4623-3227</orcidid><orcidid>https://orcid.org/0000-0002-5315-8675</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1743-5889 |
| ispartof | Nanomedicine (London, England), 2022-12, Vol.17 (29), p.2173-2187 |
| issn | 1743-5889 1748-6963 |
| language | eng |
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| source | MEDLINE; PubMed Central |
| subjects | Alzheimer Disease - diagnostic imaging Amyloid beta-Peptides - metabolism Animals Bioengineering Brain - diagnostic imaging Brain - metabolism Disease Models, Animal Imaging Life Sciences Mice Mice, Transgenic Multimodal Imaging Nanoparticles Neurobiology Neurons and Cognition Rats Tissue Distribution |
| title | In vivo targeting and multimodal imaging of cerebral amyloid-β aggregates using hybrid GdF 3 nanoparticles |
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