Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study

•High rate of sustained response after TPO-RA discontinuation in patients with persistent or chronic ITP achieving initial CR on treatment.•Increased expression of CD69 on CD8+ T cells at the time of tapering TPO-RA could predict relapses. [Display omitted] Sustained response off treatment (SROT) af...

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Veröffentlicht in:	Blood 2023-06, Vol.141 (23), p.2867-2877
Hauptverfasser:	Guillet, Stéphanie, Crickx, Etienne, Azzaoui, Imane, Chappert, Pascal, Boutin, Emmanuelle, Viallard, Jean-François, Rivière, Etienne, Gobert, Delphine, Galicier, Lionel, Malphettes, Marion, Cheze, Stéphane, Lefrere, François, Audia, Sylvain, Bonnotte, Bernard, Lambotte, Olivier, Noel, Nicolas, Fain, Olivier, Moulis, Guillaume, Hamidou, Mohamed, Gerfaud-Valentin, Mathieu, Marolleau, Jean-Pierre, Terriou, Louis, Martis, Nihal, Morin, Anne-Sophie, Perlat, Antoinette, Le Gallou, Thomas, Roy-Peaud, Frédérique, Robbins, Ailsa, Lega, Jean-Christophe, Puyade, Matthieu, Comont, Thibault, Limal, Nicolas, Languille, Laetitia, Zarrour, Anissa, Luka, Marine, Menager, Mickael, Belmondo, Thibault, Hue, Sophie, Canoui-Poitrine, Florence, Michel, Marc, Godeau, Bertrand, Mahévas, Matthieu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autoimmunity Human health and pathology Humans Hydrazines - therapeutic use Life Sciences Middle Aged Platelet Count Prospective Studies Purpura, Thrombocytopenic, Idiopathic - drug therapy Receptors, Fc - therapeutic use Recombinant Fusion Proteins - therapeutic use Thrombocytopenia - drug therapy Thrombopoietin - therapeutic use
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