Visualization of the saccule and utricle with non-contrast-enhanced FLAIR sequences
Objectives 3D-fluid attenuation inversion recovery (FLAIR) collected 4 h after intravenous gadolinium injection can delineate the perilymphatic space (PLS) from the endolymphatic space (ELS) to capture endolymphatic hydrops, the pathological counterpart of Ménière’s disease. We aimed to optimize vis...
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| Veröffentlicht in: | European radiology 2022-05, Vol.32 (5), p.3532-3540 |
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| creator | Fukutomi, Hikaru Hamitouche, Lydia Yamamoto, Takayuki Denat, Laurent Zhang, Lijun Zhang, Bei Prevost, Valentin Triaire, Bruno Dousset, Vincent Barreau, Xavier Tourdias, Thomas |
| description | Objectives
3D-fluid attenuation inversion recovery (FLAIR) collected 4 h after intravenous gadolinium injection can delineate the perilymphatic space (PLS) from the endolymphatic space (ELS) to capture endolymphatic hydrops, the pathological counterpart of Ménière’s disease. We aimed to optimize visualization of such inner ear internal anatomy using 3D-FLAIR without injection.
Methods
3D-FLAIR signal from different fluid compartments such as PLS and ELS was first simulated. Then, twenty-two healthy subjects were scanned at 3.0-T MRI with non-injected 3D-FLAIR using variable T2 preparations (T2Preps) (OFF, 200, 400, and 600 ms) and variable inversion times (TIs) (from 224 to 5000 ms) and different resolutions (1.0 × 1.0 × 1.5, 0.6 × 0.6 × 0.8, and 0.6 × 0.6 × 0.6 mm
3
). The relative contrast between PLS and ELS and the visibility of the saccule and utricle were assessed. Additionally, non-injected 3D-FLAIR with the optimal setting was tested in a Ménière patient and compared with gadolinium-injected 3D-FLAIR.
Results
The PLS and ELS were differentiated when T2Prep was used but not without. The relative contrast was larger with T2Prep at 400 ms than at 200 or 600 ms (0.72 ± 0.22
vs.
0.44 ± 0.11,
p
= 0.019; and 0.72 ± 0.22
vs.
0.46 ± 0.28,
p
= 0.034, respectively). The saccule and utricle were best delineated in 87. % cases with T2Prep = 400 and TI = 2100 ms at the highest resolution. Visualization of the saccule and utricle in the optimized non-injected 3D-FLAIR was similar to conventional injected 3D-FLAIR in a patient.
Conclusions
Combining a specific T2Prep and TI in non-injected 3D-FLAIR could separate PLS and ELS and even the saccule and utricle, paving the way toward future application to diagnose Ménière’s disease.
Key Points
•
MRI can capture the internal anatomy of inner ear without injection of contrast media.
•
Specific parameters consisting of a T2 preparation of 400 ms and an inversion time of 2100 ms must be used to visualize the saccule and utricle on non-injected 3D-FLAIR. |
| doi_str_mv | 10.1007/s00330-021-08403-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_04027135v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2612041988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-cfe79564402ec25810519ef5f443a5faf18c027ee9e59dc163357ebc4d8f71e03</originalsourceid><addsrcrecordid>eNp9kU1vFDEMhiNERUvhD3BAI3Eph4Cdj53JcVVRWmklpPJxjdKMw041m5RkhlX59aRMKYgDJ9vx49eOXsZeILxBgPZtAZASOAjk0CmQfP-IHaGSgmOtH_-VH7KnpVwDgEHVPmGHUhnRKVRH7OOXocxuHH64aUixSaGZttQU5_08UuNi38xTHnzN98O0bWKK3Kc4ZVcmTnHroqe-OdusLy6bQt9mqnV5xg6CGws9v4_H7PPZu0-n53zz4f3F6XrDvQIzcR-oNXqlFAjyQncIGg0FHZSSTgcXsPMgWiJD2vQeV1Lqlq686rvQIoE8Zq8X3a0b7U0edi7f2uQGe77e2Ls3qNItSv0dK3uysDc51TPLZHdD8TSOLlKaixUrFKDQdF1FX_2DXqc5x_qTSmnVCWXAVEoslM-plEzh4QIEe2ePXeyx1R77yx67r0Mv76Xnqx31DyO__aiAXIBSW_Er5T-7_yP7E5j_mVc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2654824909</pqid></control><display><type>article</type><title>Visualization of the saccule and utricle with non-contrast-enhanced FLAIR sequences</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Fukutomi, Hikaru ; Hamitouche, Lydia ; Yamamoto, Takayuki ; Denat, Laurent ; Zhang, Lijun ; Zhang, Bei ; Prevost, Valentin ; Triaire, Bruno ; Dousset, Vincent ; Barreau, Xavier ; Tourdias, Thomas</creator><creatorcontrib>Fukutomi, Hikaru ; Hamitouche, Lydia ; Yamamoto, Takayuki ; Denat, Laurent ; Zhang, Lijun ; Zhang, Bei ; Prevost, Valentin ; Triaire, Bruno ; Dousset, Vincent ; Barreau, Xavier ; Tourdias, Thomas</creatorcontrib><description>Objectives
3D-fluid attenuation inversion recovery (FLAIR) collected 4 h after intravenous gadolinium injection can delineate the perilymphatic space (PLS) from the endolymphatic space (ELS) to capture endolymphatic hydrops, the pathological counterpart of Ménière’s disease. We aimed to optimize visualization of such inner ear internal anatomy using 3D-FLAIR without injection.
Methods
3D-FLAIR signal from different fluid compartments such as PLS and ELS was first simulated. Then, twenty-two healthy subjects were scanned at 3.0-T MRI with non-injected 3D-FLAIR using variable T2 preparations (T2Preps) (OFF, 200, 400, and 600 ms) and variable inversion times (TIs) (from 224 to 5000 ms) and different resolutions (1.0 × 1.0 × 1.5, 0.6 × 0.6 × 0.8, and 0.6 × 0.6 × 0.6 mm
3
). The relative contrast between PLS and ELS and the visibility of the saccule and utricle were assessed. Additionally, non-injected 3D-FLAIR with the optimal setting was tested in a Ménière patient and compared with gadolinium-injected 3D-FLAIR.
Results
The PLS and ELS were differentiated when T2Prep was used but not without. The relative contrast was larger with T2Prep at 400 ms than at 200 or 600 ms (0.72 ± 0.22
vs.
0.44 ± 0.11,
p
= 0.019; and 0.72 ± 0.22
vs.
0.46 ± 0.28,
p
= 0.034, respectively). The saccule and utricle were best delineated in 87. % cases with T2Prep = 400 and TI = 2100 ms at the highest resolution. Visualization of the saccule and utricle in the optimized non-injected 3D-FLAIR was similar to conventional injected 3D-FLAIR in a patient.
Conclusions
Combining a specific T2Prep and TI in non-injected 3D-FLAIR could separate PLS and ELS and even the saccule and utricle, paving the way toward future application to diagnose Ménière’s disease.
Key Points
•
MRI can capture the internal anatomy of inner ear without injection of contrast media.
•
Specific parameters consisting of a T2 preparation of 400 ms and an inversion time of 2100 ms must be used to visualize the saccule and utricle on non-injected 3D-FLAIR.</description><identifier>ISSN: 1432-1084</identifier><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-021-08403-w</identifier><identifier>PMID: 34928414</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anatomy ; Contrast Media ; Diagnostic Radiology ; Ear ; Edema ; Endolymphatic Hydrops - diagnosis ; Gadolinium ; Gadolinium DTPA ; Head and Neck ; Humans ; Imaging ; Imaging, Three-Dimensional ; Injection ; Injections, Intravenous ; Inner ear ; Internal Medicine ; Interventional Radiology ; Intravenous administration ; Inversion ; Life Sciences ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Meniere Disease - diagnostic imaging ; Meniere's disease ; Neurons and Cognition ; Neuroradiology ; Optimization ; Radiology ; Saccule ; Saccule and Utricle ; Ultrasound ; Utricle ; Visualization</subject><ispartof>European radiology, 2022-05, Vol.32 (5), p.3532-3540</ispartof><rights>The Author(s), under exclusive licence to European Society of Radiology 2021</rights><rights>2021. The Author(s), under exclusive licence to European Society of Radiology.</rights><rights>The Author(s), under exclusive licence to European Society of Radiology 2021.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-cfe79564402ec25810519ef5f443a5faf18c027ee9e59dc163357ebc4d8f71e03</citedby><cites>FETCH-LOGICAL-c409t-cfe79564402ec25810519ef5f443a5faf18c027ee9e59dc163357ebc4d8f71e03</cites><orcidid>0000-0002-7151-6325</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-021-08403-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-021-08403-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34928414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04027135$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukutomi, Hikaru</creatorcontrib><creatorcontrib>Hamitouche, Lydia</creatorcontrib><creatorcontrib>Yamamoto, Takayuki</creatorcontrib><creatorcontrib>Denat, Laurent</creatorcontrib><creatorcontrib>Zhang, Lijun</creatorcontrib><creatorcontrib>Zhang, Bei</creatorcontrib><creatorcontrib>Prevost, Valentin</creatorcontrib><creatorcontrib>Triaire, Bruno</creatorcontrib><creatorcontrib>Dousset, Vincent</creatorcontrib><creatorcontrib>Barreau, Xavier</creatorcontrib><creatorcontrib>Tourdias, Thomas</creatorcontrib><title>Visualization of the saccule and utricle with non-contrast-enhanced FLAIR sequences</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
3D-fluid attenuation inversion recovery (FLAIR) collected 4 h after intravenous gadolinium injection can delineate the perilymphatic space (PLS) from the endolymphatic space (ELS) to capture endolymphatic hydrops, the pathological counterpart of Ménière’s disease. We aimed to optimize visualization of such inner ear internal anatomy using 3D-FLAIR without injection.
Methods
3D-FLAIR signal from different fluid compartments such as PLS and ELS was first simulated. Then, twenty-two healthy subjects were scanned at 3.0-T MRI with non-injected 3D-FLAIR using variable T2 preparations (T2Preps) (OFF, 200, 400, and 600 ms) and variable inversion times (TIs) (from 224 to 5000 ms) and different resolutions (1.0 × 1.0 × 1.5, 0.6 × 0.6 × 0.8, and 0.6 × 0.6 × 0.6 mm
3
). The relative contrast between PLS and ELS and the visibility of the saccule and utricle were assessed. Additionally, non-injected 3D-FLAIR with the optimal setting was tested in a Ménière patient and compared with gadolinium-injected 3D-FLAIR.
Results
The PLS and ELS were differentiated when T2Prep was used but not without. The relative contrast was larger with T2Prep at 400 ms than at 200 or 600 ms (0.72 ± 0.22
vs.
0.44 ± 0.11,
p
= 0.019; and 0.72 ± 0.22
vs.
0.46 ± 0.28,
p
= 0.034, respectively). The saccule and utricle were best delineated in 87. % cases with T2Prep = 400 and TI = 2100 ms at the highest resolution. Visualization of the saccule and utricle in the optimized non-injected 3D-FLAIR was similar to conventional injected 3D-FLAIR in a patient.
Conclusions
Combining a specific T2Prep and TI in non-injected 3D-FLAIR could separate PLS and ELS and even the saccule and utricle, paving the way toward future application to diagnose Ménière’s disease.
Key Points
•
MRI can capture the internal anatomy of inner ear without injection of contrast media.
•
Specific parameters consisting of a T2 preparation of 400 ms and an inversion time of 2100 ms must be used to visualize the saccule and utricle on non-injected 3D-FLAIR.</description><subject>Anatomy</subject><subject>Contrast Media</subject><subject>Diagnostic Radiology</subject><subject>Ear</subject><subject>Edema</subject><subject>Endolymphatic Hydrops - diagnosis</subject><subject>Gadolinium</subject><subject>Gadolinium DTPA</subject><subject>Head and Neck</subject><subject>Humans</subject><subject>Imaging</subject><subject>Imaging, Three-Dimensional</subject><subject>Injection</subject><subject>Injections, Intravenous</subject><subject>Inner ear</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Intravenous administration</subject><subject>Inversion</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meniere Disease - diagnostic imaging</subject><subject>Meniere's disease</subject><subject>Neurons and Cognition</subject><subject>Neuroradiology</subject><subject>Optimization</subject><subject>Radiology</subject><subject>Saccule</subject><subject>Saccule and Utricle</subject><subject>Ultrasound</subject><subject>Utricle</subject><subject>Visualization</subject><issn>1432-1084</issn><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1vFDEMhiNERUvhD3BAI3Eph4Cdj53JcVVRWmklpPJxjdKMw041m5RkhlX59aRMKYgDJ9vx49eOXsZeILxBgPZtAZASOAjk0CmQfP-IHaGSgmOtH_-VH7KnpVwDgEHVPmGHUhnRKVRH7OOXocxuHH64aUixSaGZttQU5_08UuNi38xTHnzN98O0bWKK3Kc4ZVcmTnHroqe-OdusLy6bQt9mqnV5xg6CGws9v4_H7PPZu0-n53zz4f3F6XrDvQIzcR-oNXqlFAjyQncIGg0FHZSSTgcXsPMgWiJD2vQeV1Lqlq686rvQIoE8Zq8X3a0b7U0edi7f2uQGe77e2Ls3qNItSv0dK3uysDc51TPLZHdD8TSOLlKaixUrFKDQdF1FX_2DXqc5x_qTSmnVCWXAVEoslM-plEzh4QIEe2ePXeyx1R77yx67r0Mv76Xnqx31DyO__aiAXIBSW_Er5T-7_yP7E5j_mVc</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Fukutomi, Hikaru</creator><creator>Hamitouche, Lydia</creator><creator>Yamamoto, Takayuki</creator><creator>Denat, Laurent</creator><creator>Zhang, Lijun</creator><creator>Zhang, Bei</creator><creator>Prevost, Valentin</creator><creator>Triaire, Bruno</creator><creator>Dousset, Vincent</creator><creator>Barreau, Xavier</creator><creator>Tourdias, Thomas</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-7151-6325</orcidid></search><sort><creationdate>20220501</creationdate><title>Visualization of the saccule and utricle with non-contrast-enhanced FLAIR sequences</title><author>Fukutomi, Hikaru ; Hamitouche, Lydia ; Yamamoto, Takayuki ; Denat, Laurent ; Zhang, Lijun ; Zhang, Bei ; Prevost, Valentin ; Triaire, Bruno ; Dousset, Vincent ; Barreau, Xavier ; Tourdias, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-cfe79564402ec25810519ef5f443a5faf18c027ee9e59dc163357ebc4d8f71e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anatomy</topic><topic>Contrast Media</topic><topic>Diagnostic Radiology</topic><topic>Ear</topic><topic>Edema</topic><topic>Endolymphatic Hydrops - diagnosis</topic><topic>Gadolinium</topic><topic>Gadolinium DTPA</topic><topic>Head and Neck</topic><topic>Humans</topic><topic>Imaging</topic><topic>Imaging, Three-Dimensional</topic><topic>Injection</topic><topic>Injections, Intravenous</topic><topic>Inner ear</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Intravenous administration</topic><topic>Inversion</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meniere Disease - diagnostic imaging</topic><topic>Meniere's disease</topic><topic>Neurons and Cognition</topic><topic>Neuroradiology</topic><topic>Optimization</topic><topic>Radiology</topic><topic>Saccule</topic><topic>Saccule and Utricle</topic><topic>Ultrasound</topic><topic>Utricle</topic><topic>Visualization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukutomi, Hikaru</creatorcontrib><creatorcontrib>Hamitouche, Lydia</creatorcontrib><creatorcontrib>Yamamoto, Takayuki</creatorcontrib><creatorcontrib>Denat, Laurent</creatorcontrib><creatorcontrib>Zhang, Lijun</creatorcontrib><creatorcontrib>Zhang, Bei</creatorcontrib><creatorcontrib>Prevost, Valentin</creatorcontrib><creatorcontrib>Triaire, Bruno</creatorcontrib><creatorcontrib>Dousset, Vincent</creatorcontrib><creatorcontrib>Barreau, Xavier</creatorcontrib><creatorcontrib>Tourdias, Thomas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukutomi, Hikaru</au><au>Hamitouche, Lydia</au><au>Yamamoto, Takayuki</au><au>Denat, Laurent</au><au>Zhang, Lijun</au><au>Zhang, Bei</au><au>Prevost, Valentin</au><au>Triaire, Bruno</au><au>Dousset, Vincent</au><au>Barreau, Xavier</au><au>Tourdias, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visualization of the saccule and utricle with non-contrast-enhanced FLAIR sequences</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>32</volume><issue>5</issue><spage>3532</spage><epage>3540</epage><pages>3532-3540</pages><issn>1432-1084</issn><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
3D-fluid attenuation inversion recovery (FLAIR) collected 4 h after intravenous gadolinium injection can delineate the perilymphatic space (PLS) from the endolymphatic space (ELS) to capture endolymphatic hydrops, the pathological counterpart of Ménière’s disease. We aimed to optimize visualization of such inner ear internal anatomy using 3D-FLAIR without injection.
Methods
3D-FLAIR signal from different fluid compartments such as PLS and ELS was first simulated. Then, twenty-two healthy subjects were scanned at 3.0-T MRI with non-injected 3D-FLAIR using variable T2 preparations (T2Preps) (OFF, 200, 400, and 600 ms) and variable inversion times (TIs) (from 224 to 5000 ms) and different resolutions (1.0 × 1.0 × 1.5, 0.6 × 0.6 × 0.8, and 0.6 × 0.6 × 0.6 mm
3
). The relative contrast between PLS and ELS and the visibility of the saccule and utricle were assessed. Additionally, non-injected 3D-FLAIR with the optimal setting was tested in a Ménière patient and compared with gadolinium-injected 3D-FLAIR.
Results
The PLS and ELS were differentiated when T2Prep was used but not without. The relative contrast was larger with T2Prep at 400 ms than at 200 or 600 ms (0.72 ± 0.22
vs.
0.44 ± 0.11,
p
= 0.019; and 0.72 ± 0.22
vs.
0.46 ± 0.28,
p
= 0.034, respectively). The saccule and utricle were best delineated in 87. % cases with T2Prep = 400 and TI = 2100 ms at the highest resolution. Visualization of the saccule and utricle in the optimized non-injected 3D-FLAIR was similar to conventional injected 3D-FLAIR in a patient.
Conclusions
Combining a specific T2Prep and TI in non-injected 3D-FLAIR could separate PLS and ELS and even the saccule and utricle, paving the way toward future application to diagnose Ménière’s disease.
Key Points
•
MRI can capture the internal anatomy of inner ear without injection of contrast media.
•
Specific parameters consisting of a T2 preparation of 400 ms and an inversion time of 2100 ms must be used to visualize the saccule and utricle on non-injected 3D-FLAIR.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34928414</pmid><doi>10.1007/s00330-021-08403-w</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7151-6325</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-1084 |
| ispartof | European radiology, 2022-05, Vol.32 (5), p.3532-3540 |
| issn | 1432-1084 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_04027135v1 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Anatomy Contrast Media Diagnostic Radiology Ear Edema Endolymphatic Hydrops - diagnosis Gadolinium Gadolinium DTPA Head and Neck Humans Imaging Imaging, Three-Dimensional Injection Injections, Intravenous Inner ear Internal Medicine Interventional Radiology Intravenous administration Inversion Life Sciences Magnetic Resonance Imaging Male Medicine Medicine & Public Health Meniere Disease - diagnostic imaging Meniere's disease Neurons and Cognition Neuroradiology Optimization Radiology Saccule Saccule and Utricle Ultrasound Utricle Visualization |
| title | Visualization of the saccule and utricle with non-contrast-enhanced FLAIR sequences |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T01%3A10%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Visualization%20of%20the%20saccule%20and%20utricle%20with%20non-contrast-enhanced%20FLAIR%20sequences&rft.jtitle=European%20radiology&rft.au=Fukutomi,%20Hikaru&rft.date=2022-05-01&rft.volume=32&rft.issue=5&rft.spage=3532&rft.epage=3540&rft.pages=3532-3540&rft.issn=1432-1084&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s00330-021-08403-w&rft_dat=%3Cproquest_hal_p%3E2612041988%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2654824909&rft_id=info:pmid/34928414&rfr_iscdi=true |