Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons

Recently, we and others reported that the doublecortin gene is responsible for X-linked lissencephaly and subcortical laminar heterotopia. Here, we show that Doublecortin is expressed in the brain throughout the period of corticogenesis in migrating and differentiating neurons. Immunohistochemical s...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1999-06, Vol.23 (2), p.247-256
Hauptverfasser:	Francis, F, Koulakoff, A, Boucher, D, Chafey, P, Schaar, B, Vinet, M C, Friocourt, G, McDonnell, N, Reiner, O, Kahn, A, McConnell, S K, Berwald-Netter, Y, Denoulet, P, Chelly, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Specificity Biochemistry, Molecular Biology Brain - cytology Brain - embryology Brain - metabolism Cell Differentiation - physiology Cell Movement - physiology Cells, Cultured Cytoskeleton - metabolism Cytoskeleton - ultrastructure Genetics Immunohistochemistry In Situ Hybridization Life Sciences Mice Microtubule-Associated Proteins - biosynthesis Microtubule-Associated Proteins - physiology Neurons - metabolism Neurons - physiology Neurons - ultrastructure Neurons and Cognition Neuropeptides - biosynthesis Neuropeptides - physiology Phosphoproteins - biosynthesis Phosphoproteins - physiology Rats Rats, Long-Evans RNA, Messenger - biosynthesis Tubulin - isolation & purification Tubulin - metabolism
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