New pseudodimeric aurones as palm pocket inhibitors of Hepatitis C virus RNA-dependent RNA polymerase

The NS5B RNA-dependent RNA polymerase (RdRp) is a key enzyme for Hepatitis C Virus (HCV) replication. In addition to the catalytic site, this enzyme is characterized by the presence of at least four allosteric pockets making it an interesting target for development of inhibitors as potential anti-HC...

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Veröffentlicht in:	European journal of medicinal chemistry 2016-06, Vol.115, p.217-229
Hauptverfasser:	Meguellati, Amel, Ahmed-Belkacem, Abdelhakim, Nurisso, Alessandra, Yi, Wei, Brillet, Rozenn, Berqouch, Nawel, Chavoutier, Laura, Fortuné, Antoine, Pawlotsky, Jean-Michel, Boumendjel, Ahcène, Peuchmaur, Marine
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Aurones Benzofurans - chemical synthesis Benzofurans - chemistry Benzofurans - pharmacology Chemical Sciences Dose-Response Relationship, Drug Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Hepacivirus - enzymology Hepatitis C virus Life Sciences Microbial Sensitivity Tests Molecular Structure RNA Replicase - antagonists & inhibitors RNA Replicase - metabolism RNA-dependent RNA polymerase Structure-Activity Relationship Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - metabolism
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