Identification of Four Novel Human Genes Amplified and Overexpressed in Breast Carcinoma and Localized to the q11-q21.3 Region of Chromosome 17
We have performed differential screening of a human metastatic lymph lymph node cDNA library to identify genes possibly involved during breast cancer progression. We have identified four novel genes overexpressed in malignant tiddues. They were all located on the long arm of chromosome 17, in loci l...
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| Veröffentlicht in: | Genomics 1995-08, Vol.28 (3), p.367-376 |
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| container_title | Genomics |
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| creator | Tomasetto, C. Régnier, C. Moog-Lutz, C. Mattei, M.G. Chenard, M.P. Lidereau, R. Basset, P. Rio, M.C. |
| description | We have performed differential screening of a human metastatic lymph lymph node cDNA library to identify genes possibly involved during breast cancer progression. We have identified four novel genes overexpressed in malignant tiddues. They were all located on the long arm of chromosome 17, in loci located between q11 and q21.3, a region known to contain the
c-erbB-2 oncogene and the BRCA1 breast carcinomas, and overexpression of three of them was dependent on gene amplification in breast cancer cell lines. These findings further support the concept that human chromosome 17 specifically carries genes possibly involved in breast cancer progression. |
| doi_str_mv | 10.1006/geno.1995.1163 |
| format | Article |
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c-erbB-2 oncogene and the BRCA1 breast carcinomas, and overexpression of three of them was dependent on gene amplification in breast cancer cell lines. These findings further support the concept that human chromosome 17 specifically carries genes possibly involved in breast cancer progression.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1995.1163</identifier><identifier>PMID: 7490069</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adult ; Base Sequence ; Biological and medical sciences ; BIOLOGY AND MEDICINE, BASIC STUDIES ; Breast Neoplasms - genetics ; Cancer ; CARCINOMAS ; Chromosomes, Human, Pair 17 ; DNA HYBRIDIZATION ; DNA SEQUENCING ; DNA, Complementary ; DNA, Neoplasm ; Female ; GENE AMPLIFICATION ; Gene Library ; GENE REGULATION ; GENES ; GENETIC MAPPING ; Gynecology. Andrology. Obstetrics ; HEREDITARY DISEASES ; HUMAN CHROMOSOME 17 ; Humans ; Life Sciences ; Lymph Nodes - pathology ; Mammary gland diseases ; MAMMARY GLANDS ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Neoplasm Proteins - genetics ; Neoplasm Proteins - metabolism ; PROBES ; Tumor Cells, Cultured ; Tumors</subject><ispartof>Genomics, 1995-08, Vol.28 (3), p.367-376</ispartof><rights>1995 Academic Press</rights><rights>1995 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-b8e9c8e3ef4ac044c3929fbe943c598b545edee416ee658d3271dd3da3441b683</citedby><orcidid>0000-0001-9049-2106 ; 0000-0002-1811-5848</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0888754385711639$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3638018$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7490069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04001493$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/390657$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomasetto, C.</creatorcontrib><creatorcontrib>Régnier, C.</creatorcontrib><creatorcontrib>Moog-Lutz, C.</creatorcontrib><creatorcontrib>Mattei, M.G.</creatorcontrib><creatorcontrib>Chenard, M.P.</creatorcontrib><creatorcontrib>Lidereau, R.</creatorcontrib><creatorcontrib>Basset, P.</creatorcontrib><creatorcontrib>Rio, M.C.</creatorcontrib><title>Identification of Four Novel Human Genes Amplified and Overexpressed in Breast Carcinoma and Localized to the q11-q21.3 Region of Chromosome 17</title><title>Genomics</title><addtitle>Genomics</addtitle><description>We have performed differential screening of a human metastatic lymph lymph node cDNA library to identify genes possibly involved during breast cancer progression. We have identified four novel genes overexpressed in malignant tiddues. They were all located on the long arm of chromosome 17, in loci located between q11 and q21.3, a region known to contain the
c-erbB-2 oncogene and the BRCA1 breast carcinomas, and overexpression of three of them was dependent on gene amplification in breast cancer cell lines. These findings further support the concept that human chromosome 17 specifically carries genes possibly involved in breast cancer progression.</description><subject>Adult</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>BIOLOGY AND MEDICINE, BASIC STUDIES</subject><subject>Breast Neoplasms - genetics</subject><subject>Cancer</subject><subject>CARCINOMAS</subject><subject>Chromosomes, Human, Pair 17</subject><subject>DNA HYBRIDIZATION</subject><subject>DNA SEQUENCING</subject><subject>DNA, Complementary</subject><subject>DNA, Neoplasm</subject><subject>Female</subject><subject>GENE AMPLIFICATION</subject><subject>Gene Library</subject><subject>GENE REGULATION</subject><subject>GENES</subject><subject>GENETIC MAPPING</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>HEREDITARY DISEASES</subject><subject>HUMAN CHROMOSOME 17</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lymph Nodes - pathology</subject><subject>Mammary gland diseases</subject><subject>MAMMARY GLANDS</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Neoplasm Proteins - genetics</subject><subject>Neoplasm Proteins - metabolism</subject><subject>PROBES</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUGP0zAQhSMEWsrClRuSkRAShwQ7dhL7WKrd7UoVKyE4W4492RoldmsnFeyf4C_jkKo3TpZmvnmeNy_L3hJcEIzrz4_gfEGEqApCavosWxHMRc5rVj_PVphznjcVoy-zVzH-xBgLysur7KphIg2LVfbn3oAbbWe1Gq13yHfo1k8BffUn6NF2GpRDd-AgovVw6BMHBiln0MMJAvw6BIgxVaxDXwKoOKKNCto6P6h_1M5r1dunRIwejXtAR0LyY0kKir7B4_m_zT74wUc_ACLN6-xFp_oIb87vdfbj9ub7ZpvvHu7uN-tdrhkWY95yEJoDhY4pjRnTVJSia0EwqivB24pVYAAYqQHqihtaNsQYahRljLQ1p9fZ-0XXx9HKqO0Ieq-9c6BHSQWuqyYxnxZmr3p5CHZQ4bf0ysrteifnGmYYEyboiST248Iegj9OEEc52Kih75UDP0XZNDVpGl4msFhAHXyMAbqLMsFyTlTOico5UTknmgbenZWndgBzwc8Rpv6Hc1_FdO0uKKdtvGC0phyT2TBfMEhXPVkIs2lwGowNs2fj7f82-AsfMrsq</recordid><startdate>19950810</startdate><enddate>19950810</enddate><creator>Tomasetto, C.</creator><creator>Régnier, C.</creator><creator>Moog-Lutz, C.</creator><creator>Mattei, M.G.</creator><creator>Chenard, M.P.</creator><creator>Lidereau, R.</creator><creator>Basset, P.</creator><creator>Rio, M.C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>OTOTI</scope><orcidid>https://orcid.org/0000-0001-9049-2106</orcidid><orcidid>https://orcid.org/0000-0002-1811-5848</orcidid></search><sort><creationdate>19950810</creationdate><title>Identification of Four Novel Human Genes Amplified and Overexpressed in Breast Carcinoma and Localized to the q11-q21.3 Region of Chromosome 17</title><author>Tomasetto, C. ; Régnier, C. ; Moog-Lutz, C. ; Mattei, M.G. ; Chenard, M.P. ; Lidereau, R. ; Basset, P. ; Rio, M.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-b8e9c8e3ef4ac044c3929fbe943c598b545edee416ee658d3271dd3da3441b683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>BIOLOGY AND MEDICINE, BASIC STUDIES</topic><topic>Breast Neoplasms - genetics</topic><topic>Cancer</topic><topic>CARCINOMAS</topic><topic>Chromosomes, Human, Pair 17</topic><topic>DNA HYBRIDIZATION</topic><topic>DNA SEQUENCING</topic><topic>DNA, Complementary</topic><topic>DNA, Neoplasm</topic><topic>Female</topic><topic>GENE AMPLIFICATION</topic><topic>Gene Library</topic><topic>GENE REGULATION</topic><topic>GENES</topic><topic>GENETIC MAPPING</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>HEREDITARY DISEASES</topic><topic>HUMAN CHROMOSOME 17</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Lymph Nodes - pathology</topic><topic>Mammary gland diseases</topic><topic>MAMMARY GLANDS</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Neoplasm Proteins - genetics</topic><topic>Neoplasm Proteins - metabolism</topic><topic>PROBES</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomasetto, C.</creatorcontrib><creatorcontrib>Régnier, C.</creatorcontrib><creatorcontrib>Moog-Lutz, C.</creatorcontrib><creatorcontrib>Mattei, M.G.</creatorcontrib><creatorcontrib>Chenard, M.P.</creatorcontrib><creatorcontrib>Lidereau, R.</creatorcontrib><creatorcontrib>Basset, P.</creatorcontrib><creatorcontrib>Rio, M.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>OSTI.GOV</collection><jtitle>Genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomasetto, C.</au><au>Régnier, C.</au><au>Moog-Lutz, C.</au><au>Mattei, M.G.</au><au>Chenard, M.P.</au><au>Lidereau, R.</au><au>Basset, P.</au><au>Rio, M.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of Four Novel Human Genes Amplified and Overexpressed in Breast Carcinoma and Localized to the q11-q21.3 Region of Chromosome 17</atitle><jtitle>Genomics</jtitle><addtitle>Genomics</addtitle><date>1995-08-10</date><risdate>1995</risdate><volume>28</volume><issue>3</issue><spage>367</spage><epage>376</epage><pages>367-376</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>We have performed differential screening of a human metastatic lymph lymph node cDNA library to identify genes possibly involved during breast cancer progression. We have identified four novel genes overexpressed in malignant tiddues. They were all located on the long arm of chromosome 17, in loci located between q11 and q21.3, a region known to contain the
c-erbB-2 oncogene and the BRCA1 breast carcinomas, and overexpression of three of them was dependent on gene amplification in breast cancer cell lines. These findings further support the concept that human chromosome 17 specifically carries genes possibly involved in breast cancer progression.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>7490069</pmid><doi>10.1006/geno.1995.1163</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9049-2106</orcidid><orcidid>https://orcid.org/0000-0002-1811-5848</orcidid></addata></record> |
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| ispartof | Genomics, 1995-08, Vol.28 (3), p.367-376 |
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| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_04001493v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Base Sequence Biological and medical sciences BIOLOGY AND MEDICINE, BASIC STUDIES Breast Neoplasms - genetics Cancer CARCINOMAS Chromosomes, Human, Pair 17 DNA HYBRIDIZATION DNA SEQUENCING DNA, Complementary DNA, Neoplasm Female GENE AMPLIFICATION Gene Library GENE REGULATION GENES GENETIC MAPPING Gynecology. Andrology. Obstetrics HEREDITARY DISEASES HUMAN CHROMOSOME 17 Humans Life Sciences Lymph Nodes - pathology Mammary gland diseases MAMMARY GLANDS Medical sciences Middle Aged Molecular Sequence Data Neoplasm Proteins - genetics Neoplasm Proteins - metabolism PROBES Tumor Cells, Cultured Tumors |
| title | Identification of Four Novel Human Genes Amplified and Overexpressed in Breast Carcinoma and Localized to the q11-q21.3 Region of Chromosome 17 |
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