Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity

Aim/hypothesis Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice. In humans, potential links with obesity comor...

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Veröffentlicht in:	Diabetologia 2021-01, Vol.64 (1), p.240-254
Hauptverfasser:	Rouault, Christine, Marcelin, Geneviève, Adriouch, Solia, Rose, Cindy, Genser, Laurent, Ambrosini, Marc, Bichet, Jean-Christophe, Zhang, Yanyan, Marquet, Florian, Aron-Wisnewsky, Judith, Poitou, Christine, André, Sébastien, Dérumeaux, Geneviève, Guerre-Millo, Michèle, Clément, Karine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - physiology Adipose tissue Bariatric Surgery beta-Galactosidase - metabolism Biopsy Blood Glucose - analysis Body Composition - physiology Body fat Cellular Senescence - physiology Chemokines Cohort Studies Diabetes Diabetes mellitus (non-insulin dependent) Drug delivery Dyslipidemia Fat metabolism Female Gastrointestinal surgery Glucose metabolism Human Physiology Humans Inflammation Insulin Insulin Resistance Insulin-like growth factor-binding protein 3 Interleukin 6 Internal Medicine Leptin Life Sciences Macrophages Male Medicine Medicine & Public Health Metabolic Diseases Metabolism Monocyte chemoattractant protein 1 Obesity Obesity, Morbid - metabolism Obesity, Morbid - physiopathology Obesity, Morbid - surgery Phenotypes Plasminogen activator inhibitors Prospective Studies Senescence Subcutaneous Fat - enzymology Subcutaneous Fat - pathology Surgery Treatment Outcome β-Galactosidase
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