Oleuropein activated AMPK and induced insulin sensitivity in C2C12 muscle cells

Oleuropein has been recognized as an important medicinal compound because of its various biological properties, including anti-cancer, antidiabetic and anti-atherosclerotic activities. Here, we evaluate the antioxidant activity as well as the mechanism of the hypoglycemic effects of oleuropein in C2...

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Veröffentlicht in:	Life sciences (1973) 2016-04, Vol.151, p.167-173
Hauptverfasser:	Hadrich, Fatma, Garcia, Marie, Maalej, Amina, Moldes, Marthe, Isoda, Hiroko, Feve, Bruno, Sayadi, Sami
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism AMPK Animals Cell Line Cell Survival - drug effects DNA-Binding Proteins - metabolism Drug Synergism Enzyme Activation - drug effects Hydrogen Peroxide - toxicity Hypoglycemic Agents - pharmacology Insulin - metabolism Insulin Resistance Insulin sensitivity Iridoids - pharmacology Life Sciences MAPK Mice Mitogen-Activated Protein Kinases - metabolism Muscle, Skeletal - cytology Muscle, Skeletal - enzymology Muscle, Skeletal - metabolism Oleuropein Oxidative Stress - drug effects Phosphatidylinositol 3-Kinase - metabolism Phosphorylation - drug effects Protective Agents - pharmacology Reactive Oxygen Species - metabolism Signal Transduction - drug effects Skeletal muscle cells Thiobarbituric Acid Reactive Substances - metabolism Transcription Factors - metabolism
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