Optimal donation of kidney transplants after controlled circulatory death
Controlled donation after circulatory death (cDCD) is used for “extended criteria” donors with poorer kidney transplant outcomes. The French cDCD program started in 2015 and is characterized by normothermic regional perfusion, hypothermic machine perfusion, and short cold ischemia time. We compared...
Gespeichert in:
| Veröffentlicht in: | American journal of transplantation 2021-07, Vol.21 (7), p.2424-2436 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2436 |
|---|---|
| container_issue | 7 |
| container_start_page | 2424 |
| container_title | American journal of transplantation |
| container_volume | 21 |
| creator | Savoye, Emilie Legeai, Camille Branchereau, Julien Gay, Samuel Riou, Bruno Gaudez, Francois Veber, Benoit Bruyere, Franck Cheisson, Gaelle Kerforne, Thomas Badet, Lionel Bastien, Olivier Antoine, Corinne |
| description | Controlled donation after circulatory death (cDCD) is used for “extended criteria” donors with poorer kidney transplant outcomes. The French cDCD program started in 2015 and is characterized by normothermic regional perfusion, hypothermic machine perfusion, and short cold ischemia time. We compared the outcomes of kidney transplantation from cDCD and brain‐dead (DBD) donors, matching cDCD and DBD kidney transplants by propensity scoring for donor and recipient characteristics. The matching process retained 442 of 499 cDCD and 809 of 6185 DBD transplantations. The DGF rate was 20% in cDCD recipients compared with 28% in DBD recipients (adjusted relative risk [aRR], 1.43; 95% confidence interval [CI] 1.12–1.82). When DBD transplants were ranked by cold ischemia time and machine perfusion use and compared with cDCD transplants, the aRR of DGF was higher for DBD transplants without machine perfusion, regardless of the cold ischemia time (aRR with cold ischemia time |
| doi_str_mv | 10.1111/ajt.16425 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03996957v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2759001434</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4225-5b2cdb9debd32a64a5cbc10a1de9ca40c73ee04972d6d056e1a81962ecfc7fb53</originalsourceid><addsrcrecordid>eNp1kUtLAzEQx4Movg9-AVnwoodq3tsci_ik4EXPIZvM4tZ0U5Os0m9vtFpBcC4zDD_-8_gjdETwOSlxYWb5nEhOxQbaJRLjkSScba5rJnbQXkozjElNx3Qb7TApask42UV3D4vczY2vXOhN7kJfhbZ66VwPyypH06eFN31OlWkzxMqGPsfgPbjKdtEO3uQQl5UDk58P0FZrfILD77yPnq6vHi9vR9OHm7vLyXRkOaViJBpqXaMcNI5RI7kRtrEEG-JAWcOxrRkA5qqmTjosJBAzJkpSsK2t20awfXS20n02Xi9iWT4udTCdvp1M9WcPM6WkEvUbKezpil3E8DpAynreJQu-3ARhSJrWQpWvcMYLevIHnYUh9uUSTQWX4zFWgvwOtzGkFKFdb0Cw_vRCFy_0lxeFPf5WHJo5uDX58_wCXKyA987D8n8lPbl_XEl-AKGXkqE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2546880951</pqid></control><display><type>article</type><title>Optimal donation of kidney transplants after controlled circulatory death</title><source>MEDLINE</source><source>Wiley Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Savoye, Emilie ; Legeai, Camille ; Branchereau, Julien ; Gay, Samuel ; Riou, Bruno ; Gaudez, Francois ; Veber, Benoit ; Bruyere, Franck ; Cheisson, Gaelle ; Kerforne, Thomas ; Badet, Lionel ; Bastien, Olivier ; Antoine, Corinne</creator><creatorcontrib>Savoye, Emilie ; Legeai, Camille ; Branchereau, Julien ; Gay, Samuel ; Riou, Bruno ; Gaudez, Francois ; Veber, Benoit ; Bruyere, Franck ; Cheisson, Gaelle ; Kerforne, Thomas ; Badet, Lionel ; Bastien, Olivier ; Antoine, Corinne ; cDCD National Steering Committee</creatorcontrib><description>Controlled donation after circulatory death (cDCD) is used for “extended criteria” donors with poorer kidney transplant outcomes. The French cDCD program started in 2015 and is characterized by normothermic regional perfusion, hypothermic machine perfusion, and short cold ischemia time. We compared the outcomes of kidney transplantation from cDCD and brain‐dead (DBD) donors, matching cDCD and DBD kidney transplants by propensity scoring for donor and recipient characteristics. The matching process retained 442 of 499 cDCD and 809 of 6185 DBD transplantations. The DGF rate was 20% in cDCD recipients compared with 28% in DBD recipients (adjusted relative risk [aRR], 1.43; 95% confidence interval [CI] 1.12–1.82). When DBD transplants were ranked by cold ischemia time and machine perfusion use and compared with cDCD transplants, the aRR of DGF was higher for DBD transplants without machine perfusion, regardless of the cold ischemia time (aRR with cold ischemia time <18 h, 1.57; 95% CI 1.20–2.03, vs aRR with cold ischemia time ≥18 h, 1.79; 95% CI 1.31–2.44). The 1‐year graft survival rate was similar in both groups. Early outcome was better for kidney transplants from cDCD than from matched DBD transplants with this French protocol.
A nationwide protocol for kidneys from controlled donation after circulatory death donors, characterized by systematic normothermic regional perfusion after death until kidney recovery, hypothermic machine perfusion until transplantation, and short cold ischemia times, is associated with significantly lower risk of delayed graft function and comparable 1‐year graft and patient survival rates, compared to kidneys from brain death donors.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/ajt.16425</identifier><identifier>PMID: 36576341</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Brain Death ; Cold ; Cold Ischemia ; Death ; Donors ; donors and donation: donation after circulatory death (DCD) ; Graft Survival ; health services and outcomes research ; Humans ; Ischemia ; ischemia reperfusion injury (IRI) ; Kidney Transplantation ; kidney transplantation/nephrology ; Kidney transplants ; Life Sciences ; organ procurement and allocation ; Perfusion ; Retrospective Studies ; Tissue and Organ Procurement ; Tissue Donors</subject><ispartof>American journal of transplantation, 2021-07, Vol.21 (7), p.2424-2436</ispartof><rights>2020 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>2020 The American Society of Transplantation and the American Society of Transplant Surgeons.</rights><rights>2021 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4225-5b2cdb9debd32a64a5cbc10a1de9ca40c73ee04972d6d056e1a81962ecfc7fb53</citedby><cites>FETCH-LOGICAL-c4225-5b2cdb9debd32a64a5cbc10a1de9ca40c73ee04972d6d056e1a81962ecfc7fb53</cites><orcidid>0000-0001-7752-1144 ; 0000-0002-9098-0203 ; 0000-0002-8460-9352 ; 0000-0002-0611-4100</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajt.16425$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajt.16425$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36576341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03996957$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Savoye, Emilie</creatorcontrib><creatorcontrib>Legeai, Camille</creatorcontrib><creatorcontrib>Branchereau, Julien</creatorcontrib><creatorcontrib>Gay, Samuel</creatorcontrib><creatorcontrib>Riou, Bruno</creatorcontrib><creatorcontrib>Gaudez, Francois</creatorcontrib><creatorcontrib>Veber, Benoit</creatorcontrib><creatorcontrib>Bruyere, Franck</creatorcontrib><creatorcontrib>Cheisson, Gaelle</creatorcontrib><creatorcontrib>Kerforne, Thomas</creatorcontrib><creatorcontrib>Badet, Lionel</creatorcontrib><creatorcontrib>Bastien, Olivier</creatorcontrib><creatorcontrib>Antoine, Corinne</creatorcontrib><creatorcontrib>cDCD National Steering Committee</creatorcontrib><title>Optimal donation of kidney transplants after controlled circulatory death</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>Controlled donation after circulatory death (cDCD) is used for “extended criteria” donors with poorer kidney transplant outcomes. The French cDCD program started in 2015 and is characterized by normothermic regional perfusion, hypothermic machine perfusion, and short cold ischemia time. We compared the outcomes of kidney transplantation from cDCD and brain‐dead (DBD) donors, matching cDCD and DBD kidney transplants by propensity scoring for donor and recipient characteristics. The matching process retained 442 of 499 cDCD and 809 of 6185 DBD transplantations. The DGF rate was 20% in cDCD recipients compared with 28% in DBD recipients (adjusted relative risk [aRR], 1.43; 95% confidence interval [CI] 1.12–1.82). When DBD transplants were ranked by cold ischemia time and machine perfusion use and compared with cDCD transplants, the aRR of DGF was higher for DBD transplants without machine perfusion, regardless of the cold ischemia time (aRR with cold ischemia time <18 h, 1.57; 95% CI 1.20–2.03, vs aRR with cold ischemia time ≥18 h, 1.79; 95% CI 1.31–2.44). The 1‐year graft survival rate was similar in both groups. Early outcome was better for kidney transplants from cDCD than from matched DBD transplants with this French protocol.
A nationwide protocol for kidneys from controlled donation after circulatory death donors, characterized by systematic normothermic regional perfusion after death until kidney recovery, hypothermic machine perfusion until transplantation, and short cold ischemia times, is associated with significantly lower risk of delayed graft function and comparable 1‐year graft and patient survival rates, compared to kidneys from brain death donors.</description><subject>Brain Death</subject><subject>Cold</subject><subject>Cold Ischemia</subject><subject>Death</subject><subject>Donors</subject><subject>donors and donation: donation after circulatory death (DCD)</subject><subject>Graft Survival</subject><subject>health services and outcomes research</subject><subject>Humans</subject><subject>Ischemia</subject><subject>ischemia reperfusion injury (IRI)</subject><subject>Kidney Transplantation</subject><subject>kidney transplantation/nephrology</subject><subject>Kidney transplants</subject><subject>Life Sciences</subject><subject>organ procurement and allocation</subject><subject>Perfusion</subject><subject>Retrospective Studies</subject><subject>Tissue and Organ Procurement</subject><subject>Tissue Donors</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLAzEQx4Movg9-AVnwoodq3tsci_ik4EXPIZvM4tZ0U5Os0m9vtFpBcC4zDD_-8_gjdETwOSlxYWb5nEhOxQbaJRLjkSScba5rJnbQXkozjElNx3Qb7TApask42UV3D4vczY2vXOhN7kJfhbZ66VwPyypH06eFN31OlWkzxMqGPsfgPbjKdtEO3uQQl5UDk58P0FZrfILD77yPnq6vHi9vR9OHm7vLyXRkOaViJBpqXaMcNI5RI7kRtrEEG-JAWcOxrRkA5qqmTjosJBAzJkpSsK2t20awfXS20n02Xi9iWT4udTCdvp1M9WcPM6WkEvUbKezpil3E8DpAynreJQu-3ARhSJrWQpWvcMYLevIHnYUh9uUSTQWX4zFWgvwOtzGkFKFdb0Cw_vRCFy_0lxeFPf5WHJo5uDX58_wCXKyA987D8n8lPbl_XEl-AKGXkqE</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Savoye, Emilie</creator><creator>Legeai, Camille</creator><creator>Branchereau, Julien</creator><creator>Gay, Samuel</creator><creator>Riou, Bruno</creator><creator>Gaudez, Francois</creator><creator>Veber, Benoit</creator><creator>Bruyere, Franck</creator><creator>Cheisson, Gaelle</creator><creator>Kerforne, Thomas</creator><creator>Badet, Lionel</creator><creator>Bastien, Olivier</creator><creator>Antoine, Corinne</creator><general>Elsevier Limited</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-7752-1144</orcidid><orcidid>https://orcid.org/0000-0002-9098-0203</orcidid><orcidid>https://orcid.org/0000-0002-8460-9352</orcidid><orcidid>https://orcid.org/0000-0002-0611-4100</orcidid></search><sort><creationdate>202107</creationdate><title>Optimal donation of kidney transplants after controlled circulatory death</title><author>Savoye, Emilie ; Legeai, Camille ; Branchereau, Julien ; Gay, Samuel ; Riou, Bruno ; Gaudez, Francois ; Veber, Benoit ; Bruyere, Franck ; Cheisson, Gaelle ; Kerforne, Thomas ; Badet, Lionel ; Bastien, Olivier ; Antoine, Corinne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4225-5b2cdb9debd32a64a5cbc10a1de9ca40c73ee04972d6d056e1a81962ecfc7fb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Brain Death</topic><topic>Cold</topic><topic>Cold Ischemia</topic><topic>Death</topic><topic>Donors</topic><topic>donors and donation: donation after circulatory death (DCD)</topic><topic>Graft Survival</topic><topic>health services and outcomes research</topic><topic>Humans</topic><topic>Ischemia</topic><topic>ischemia reperfusion injury (IRI)</topic><topic>Kidney Transplantation</topic><topic>kidney transplantation/nephrology</topic><topic>Kidney transplants</topic><topic>Life Sciences</topic><topic>organ procurement and allocation</topic><topic>Perfusion</topic><topic>Retrospective Studies</topic><topic>Tissue and Organ Procurement</topic><topic>Tissue Donors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Savoye, Emilie</creatorcontrib><creatorcontrib>Legeai, Camille</creatorcontrib><creatorcontrib>Branchereau, Julien</creatorcontrib><creatorcontrib>Gay, Samuel</creatorcontrib><creatorcontrib>Riou, Bruno</creatorcontrib><creatorcontrib>Gaudez, Francois</creatorcontrib><creatorcontrib>Veber, Benoit</creatorcontrib><creatorcontrib>Bruyere, Franck</creatorcontrib><creatorcontrib>Cheisson, Gaelle</creatorcontrib><creatorcontrib>Kerforne, Thomas</creatorcontrib><creatorcontrib>Badet, Lionel</creatorcontrib><creatorcontrib>Bastien, Olivier</creatorcontrib><creatorcontrib>Antoine, Corinne</creatorcontrib><creatorcontrib>cDCD National Steering Committee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>American journal of transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Savoye, Emilie</au><au>Legeai, Camille</au><au>Branchereau, Julien</au><au>Gay, Samuel</au><au>Riou, Bruno</au><au>Gaudez, Francois</au><au>Veber, Benoit</au><au>Bruyere, Franck</au><au>Cheisson, Gaelle</au><au>Kerforne, Thomas</au><au>Badet, Lionel</au><au>Bastien, Olivier</au><au>Antoine, Corinne</au><aucorp>cDCD National Steering Committee</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimal donation of kidney transplants after controlled circulatory death</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2021-07</date><risdate>2021</risdate><volume>21</volume><issue>7</issue><spage>2424</spage><epage>2436</epage><pages>2424-2436</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>Controlled donation after circulatory death (cDCD) is used for “extended criteria” donors with poorer kidney transplant outcomes. The French cDCD program started in 2015 and is characterized by normothermic regional perfusion, hypothermic machine perfusion, and short cold ischemia time. We compared the outcomes of kidney transplantation from cDCD and brain‐dead (DBD) donors, matching cDCD and DBD kidney transplants by propensity scoring for donor and recipient characteristics. The matching process retained 442 of 499 cDCD and 809 of 6185 DBD transplantations. The DGF rate was 20% in cDCD recipients compared with 28% in DBD recipients (adjusted relative risk [aRR], 1.43; 95% confidence interval [CI] 1.12–1.82). When DBD transplants were ranked by cold ischemia time and machine perfusion use and compared with cDCD transplants, the aRR of DGF was higher for DBD transplants without machine perfusion, regardless of the cold ischemia time (aRR with cold ischemia time <18 h, 1.57; 95% CI 1.20–2.03, vs aRR with cold ischemia time ≥18 h, 1.79; 95% CI 1.31–2.44). The 1‐year graft survival rate was similar in both groups. Early outcome was better for kidney transplants from cDCD than from matched DBD transplants with this French protocol.
A nationwide protocol for kidneys from controlled donation after circulatory death donors, characterized by systematic normothermic regional perfusion after death until kidney recovery, hypothermic machine perfusion until transplantation, and short cold ischemia times, is associated with significantly lower risk of delayed graft function and comparable 1‐year graft and patient survival rates, compared to kidneys from brain death donors.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>36576341</pmid><doi>10.1111/ajt.16425</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-7752-1144</orcidid><orcidid>https://orcid.org/0000-0002-9098-0203</orcidid><orcidid>https://orcid.org/0000-0002-8460-9352</orcidid><orcidid>https://orcid.org/0000-0002-0611-4100</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1600-6135 |
| ispartof | American journal of transplantation, 2021-07, Vol.21 (7), p.2424-2436 |
| issn | 1600-6135 1600-6143 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03996957v1 |
| source | MEDLINE; Wiley Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Brain Death Cold Cold Ischemia Death Donors donors and donation: donation after circulatory death (DCD) Graft Survival health services and outcomes research Humans Ischemia ischemia reperfusion injury (IRI) Kidney Transplantation kidney transplantation/nephrology Kidney transplants Life Sciences organ procurement and allocation Perfusion Retrospective Studies Tissue and Organ Procurement Tissue Donors |
| title | Optimal donation of kidney transplants after controlled circulatory death |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T13%3A09%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Optimal%20donation%20of%20kidney%20transplants%20after%20controlled%20circulatory%20death&rft.jtitle=American%20journal%20of%20transplantation&rft.au=Savoye,%20Emilie&rft.aucorp=cDCD%20National%20Steering%20Committee&rft.date=2021-07&rft.volume=21&rft.issue=7&rft.spage=2424&rft.epage=2436&rft.pages=2424-2436&rft.issn=1600-6135&rft.eissn=1600-6143&rft_id=info:doi/10.1111/ajt.16425&rft_dat=%3Cproquest_hal_p%3E2759001434%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2546880951&rft_id=info:pmid/36576341&rfr_iscdi=true |