Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey
The age of onset of rheumatoid arthritis (RA) is an important outcome predictor. Northern countries report an age of RA onset of around 50 years, but apparently, variability exists across different geographical regions. The objective of the present study is to assess whether the age of onset of RA v...
Gespeichert in:
| Veröffentlicht in: | Clinical rheumatology 2017-03, Vol.36 (3), p.485-497 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 497 |
|---|---|
| container_issue | 3 |
| container_start_page | 485 |
| container_title | Clinical rheumatology |
| container_volume | 36 |
| creator | Berenbaum, Francis |
| description | The age of onset of rheumatoid arthritis (RA) is an important outcome predictor. Northern countries report an age of RA onset of around 50 years, but apparently, variability exists across different geographical regions. The objective of the present study is to assess whether the age of onset of RA varies across latitudes worldwide. In a proof-of-concept cross-sectional worldwide survey, rheumatologists from preselected cities interviewed 20 consecutive RA patients regarding the date of RA onset (RAO, when the patient first noted a swollen joint). Other studied variables included location of each city, rheumatologist settings, latitudes (10° increments, south to north), longitudes (three regions), intracountry consistency, and countries’ Inequality-adjusted Human Development Index (IHDI). Data from 2481 patients (82% females) were obtained from 126 rheumatologists in 77 cities of 41 countries. Worldwide mean age of RAO was 44 ± 14 years (95% CI 44–45). In 28% of patients, RA began before age 36 years and before age 46 years in 50% of patients. RAO was 8 years earlier around the Tropic of Cancer when compared with northern latitudes (
p
|
| doi_str_mv | 10.1007/s10067-016-3481-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03994342v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1851300249</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-d14e560928b6400b6e1224ecde022128ae53c4a49273cc6336c6b8cb26ba337c3</originalsourceid><addsrcrecordid>eNp9kLtOwzAUQC0EgvL4ABbkEYaAX3VitqriJVVigYHJcpzb1iiNwXaK-HscBTqy2Nb1uWc4CJ1Tck0JKW9iPmVZECoLLipaqD00oYKLQimh9tGElCUpOFXVETqO8Z0QwipFD9ERK5Wa8opN0NvCJJf6BvAqmMZBl7Drlm0PnYWI0xqwWQH2S-y7CGl4hDX0G5O8a7AJaR1ccvEWG_zlQ9t8uWyKfdjC9yk6WJo2wtnvfYJe7-9e5o_F4vnhaT5bFFYwmoqGCphKolhVS0FILYEyJsA2QBijrDIw5VYYoVjJrZWcSyvrytZM1obz0vITdDV616bVH8FtTPjW3jj9OFvoYUZ4zsEF29LMXo7sR_CfPcSkNy5aaFvTge-jptWU8lxJqIzSEbXBxxhguXNToof6eqyvc3091NfDzsWvvq830Ow2_nJngI1AzF_dCoJ-933ocp5_rD_SDo7N</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1851300249</pqid></control><display><type>article</type><title>Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Berenbaum, Francis</creator><creatorcontrib>Berenbaum, Francis ; GEO-RA Group</creatorcontrib><description>The age of onset of rheumatoid arthritis (RA) is an important outcome predictor. Northern countries report an age of RA onset of around 50 years, but apparently, variability exists across different geographical regions. The objective of the present study is to assess whether the age of onset of RA varies across latitudes worldwide. In a proof-of-concept cross-sectional worldwide survey, rheumatologists from preselected cities interviewed 20 consecutive RA patients regarding the date of RA onset (RAO, when the patient first noted a swollen joint). Other studied variables included location of each city, rheumatologist settings, latitudes (10° increments, south to north), longitudes (three regions), intracountry consistency, and countries’ Inequality-adjusted Human Development Index (IHDI). Data from 2481 patients (82% females) were obtained from 126 rheumatologists in 77 cities of 41 countries. Worldwide mean age of RAO was 44 ± 14 years (95% CI 44–45). In 28% of patients, RA began before age 36 years and before age 46 years in 50% of patients. RAO was 8 years earlier around the Tropic of Cancer when compared with northern latitudes (
p
< 0.001, 95% CI 3.5–13). Multivariate analysis showed that females, western cities, and latitudes around the Tropic of Cancer are associated with younger age of RAO (
R
2
0.045,
p
< 0.001). A positive correlation was found between the age of RAO and IHDI (
r
= 0.7,
p
< 0.01,
R
2
0.5). RA often begins at an early age and onset varies across latitudes worldwide. We postulate that countries’ developmental status and their geographical and geomagnetic location influence the age of RAO.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-016-3481-9</identifier><identifier>PMID: 27995382</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Adult ; Age of Onset ; Arthritis, Rheumatoid - diagnosis ; Arthritis, Rheumatoid - epidemiology ; Cross-Sectional Studies ; Disease Progression ; Female ; Humans ; Life Sciences ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Prognosis ; Rheumatology ; Severity of Illness Index ; Surveys and Questionnaires</subject><ispartof>Clinical rheumatology, 2017-03, Vol.36 (3), p.485-497</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2016</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-d14e560928b6400b6e1224ecde022128ae53c4a49273cc6336c6b8cb26ba337c3</citedby><cites>FETCH-LOGICAL-c421t-d14e560928b6400b6e1224ecde022128ae53c4a49273cc6336c6b8cb26ba337c3</cites><orcidid>0000-0001-8252-7815</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-016-3481-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-016-3481-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27995382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-03994342$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Berenbaum, Francis</creatorcontrib><creatorcontrib>GEO-RA Group</creatorcontrib><title>Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>The age of onset of rheumatoid arthritis (RA) is an important outcome predictor. Northern countries report an age of RA onset of around 50 years, but apparently, variability exists across different geographical regions. The objective of the present study is to assess whether the age of onset of RA varies across latitudes worldwide. In a proof-of-concept cross-sectional worldwide survey, rheumatologists from preselected cities interviewed 20 consecutive RA patients regarding the date of RA onset (RAO, when the patient first noted a swollen joint). Other studied variables included location of each city, rheumatologist settings, latitudes (10° increments, south to north), longitudes (three regions), intracountry consistency, and countries’ Inequality-adjusted Human Development Index (IHDI). Data from 2481 patients (82% females) were obtained from 126 rheumatologists in 77 cities of 41 countries. Worldwide mean age of RAO was 44 ± 14 years (95% CI 44–45). In 28% of patients, RA began before age 36 years and before age 46 years in 50% of patients. RAO was 8 years earlier around the Tropic of Cancer when compared with northern latitudes (
p
< 0.001, 95% CI 3.5–13). Multivariate analysis showed that females, western cities, and latitudes around the Tropic of Cancer are associated with younger age of RAO (
R
2
0.045,
p
< 0.001). A positive correlation was found between the age of RAO and IHDI (
r
= 0.7,
p
< 0.01,
R
2
0.5). RA often begins at an early age and onset varies across latitudes worldwide. We postulate that countries’ developmental status and their geographical and geomagnetic location influence the age of RAO.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Arthritis, Rheumatoid - diagnosis</subject><subject>Arthritis, Rheumatoid - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Rheumatology</subject><subject>Severity of Illness Index</subject><subject>Surveys and Questionnaires</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOwzAUQC0EgvL4ABbkEYaAX3VitqriJVVigYHJcpzb1iiNwXaK-HscBTqy2Nb1uWc4CJ1Tck0JKW9iPmVZECoLLipaqD00oYKLQimh9tGElCUpOFXVETqO8Z0QwipFD9ERK5Wa8opN0NvCJJf6BvAqmMZBl7Drlm0PnYWI0xqwWQH2S-y7CGl4hDX0G5O8a7AJaR1ccvEWG_zlQ9t8uWyKfdjC9yk6WJo2wtnvfYJe7-9e5o_F4vnhaT5bFFYwmoqGCphKolhVS0FILYEyJsA2QBijrDIw5VYYoVjJrZWcSyvrytZM1obz0vITdDV616bVH8FtTPjW3jj9OFvoYUZ4zsEF29LMXo7sR_CfPcSkNy5aaFvTge-jptWU8lxJqIzSEbXBxxhguXNToof6eqyvc3091NfDzsWvvq830Ow2_nJngI1AzF_dCoJ-933ocp5_rD_SDo7N</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Berenbaum, Francis</creator><general>Springer London</general><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-8252-7815</orcidid></search><sort><creationdate>20170301</creationdate><title>Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey</title><author>Berenbaum, Francis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-d14e560928b6400b6e1224ecde022128ae53c4a49273cc6336c6b8cb26ba337c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Arthritis, Rheumatoid - diagnosis</topic><topic>Arthritis, Rheumatoid - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Rheumatology</topic><topic>Severity of Illness Index</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berenbaum, Francis</creatorcontrib><creatorcontrib>GEO-RA Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berenbaum, Francis</au><aucorp>GEO-RA Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>36</volume><issue>3</issue><spage>485</spage><epage>497</epage><pages>485-497</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>The age of onset of rheumatoid arthritis (RA) is an important outcome predictor. Northern countries report an age of RA onset of around 50 years, but apparently, variability exists across different geographical regions. The objective of the present study is to assess whether the age of onset of RA varies across latitudes worldwide. In a proof-of-concept cross-sectional worldwide survey, rheumatologists from preselected cities interviewed 20 consecutive RA patients regarding the date of RA onset (RAO, when the patient first noted a swollen joint). Other studied variables included location of each city, rheumatologist settings, latitudes (10° increments, south to north), longitudes (three regions), intracountry consistency, and countries’ Inequality-adjusted Human Development Index (IHDI). Data from 2481 patients (82% females) were obtained from 126 rheumatologists in 77 cities of 41 countries. Worldwide mean age of RAO was 44 ± 14 years (95% CI 44–45). In 28% of patients, RA began before age 36 years and before age 46 years in 50% of patients. RAO was 8 years earlier around the Tropic of Cancer when compared with northern latitudes (
p
< 0.001, 95% CI 3.5–13). Multivariate analysis showed that females, western cities, and latitudes around the Tropic of Cancer are associated with younger age of RAO (
R
2
0.045,
p
< 0.001). A positive correlation was found between the age of RAO and IHDI (
r
= 0.7,
p
< 0.01,
R
2
0.5). RA often begins at an early age and onset varies across latitudes worldwide. We postulate that countries’ developmental status and their geographical and geomagnetic location influence the age of RAO.</abstract><cop>London</cop><pub>Springer London</pub><pmid>27995382</pmid><doi>10.1007/s10067-016-3481-9</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8252-7815</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0770-3198 |
| ispartof | Clinical rheumatology, 2017-03, Vol.36 (3), p.485-497 |
| issn | 0770-3198 1434-9949 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03994342v1 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Age of Onset Arthritis, Rheumatoid - diagnosis Arthritis, Rheumatoid - epidemiology Cross-Sectional Studies Disease Progression Female Humans Life Sciences Male Medicine Medicine & Public Health Middle Aged Original Article Prognosis Rheumatology Severity of Illness Index Surveys and Questionnaires |
| title | Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T09%3A21%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Latitude%20gradient%20influences%20the%20age%20of%20onset%20of%20rheumatoid%20arthritis:%20a%20worldwide%20survey&rft.jtitle=Clinical%20rheumatology&rft.au=Berenbaum,%20Francis&rft.aucorp=GEO-RA%20Group&rft.date=2017-03-01&rft.volume=36&rft.issue=3&rft.spage=485&rft.epage=497&rft.pages=485-497&rft.issn=0770-3198&rft.eissn=1434-9949&rft_id=info:doi/10.1007/s10067-016-3481-9&rft_dat=%3Cproquest_hal_p%3E1851300249%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1851300249&rft_id=info:pmid/27995382&rfr_iscdi=true |