Apelin and the proopiomelanocortin system: a new regulatory pathway of hypothalamic α-MSH release

Neuronal networks originating in the hypothalamic arcuate nucleus (Arc) play a fundamental role in controlling energy balance. In the Arc, neuropeptide Y (NPY)-producing neurons stimulate food intake, whereas neurons releasing the proopiomelanocortin (POMC)-derived peptide α-melanocyte-stimulating h...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2011-11, Vol.301 (5), p.E955-E966
Hauptverfasser:	Reaux-Le Goazigo, Annabelle, Bodineau, Laurence, De Mota, Nadia, Jeandel, Lydie, Chartrel, Nicolas, Knauf, Claude, Raad, Carine, Valet, Philippe, Llorens-Cortes, Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines alpha-MSH - metabolism alpha-MSH - secretion Animals Apelin Hypothalamus - drug effects Hypothalamus - metabolism Hypothalamus - pathology Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - pharmacology Intercellular Signaling Peptides and Proteins - physiology Life Sciences Male Mice Mice, Inbred C57BL Mice, Obese Models, Biological Obesity - metabolism Obesity - pathology Pro-Opiomelanocortin - metabolism Pro-Opiomelanocortin - pharmacology Pro-Opiomelanocortin - physiology Rats Rats, Sprague-Dawley Rats, Wistar Rats, Zucker Signal Transduction - drug effects
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