Risk stratification integrating genetic data for factor VIII inhibitor development in patients with severe hemophilia A

Replacement therapy in severe hemophilia A leads to factor VIII (FVIII) inhibitors in 30% of patients. Factor VIII gene (F8) mutation type, a family history of inhibitors, ethnicity and intensity of treatment are established risk factors, and were included in two published prediction tools based on...

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Veröffentlicht in:	PloS one 2019, Vol.14 (6)
Hauptverfasser:	Bachelet, Delphine, Albert, Thilo, Mbogning, Cyprien, Hässler, Signe, Zhang, Yuan, Schultze-Strasser, Stephan, Repessé, Yohann, Rayes, Julie, Pavlova, Anna, Pezeshkpoor, Behnaz, Liphardt, Kerstin, Davidson, Julie E, Hincelin-Méry, Agnès, Dönnes, Pierre, Lacroix-Desmazes, Sébastien, Königs, Christoph, Oldenburg, Johannes, Broët, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetics Hematology Human genetics Human health and pathology Immunology Life Sciences Populations and Evolution Santé publique et épidémiologie
Online-Zugang:	Volltext
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