Chemical synthesis of oligosaccharides and their application in new drug research
Oligosaccharides are the ubiquitous molecules of life. In order to translate human bioglycosylation into clinical applications, homogeneous samples of oligosaccharides and glycoconjugates can be obtained by chemical, enzymatic or other biological methods for systematic studies. However, the structur...
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| Veröffentlicht in: | European journal of medicinal chemistry 2023-03, Vol.249, p.115164-115164, Article 115164 |
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| container_title | European journal of medicinal chemistry |
| container_volume | 249 |
| creator | Lv, Zhimin Liu, Hongyu Hao, Huifang Rahman, Faiz-Ur Zhang, Yongmin |
| description | Oligosaccharides are the ubiquitous molecules of life. In order to translate human bioglycosylation into clinical applications, homogeneous samples of oligosaccharides and glycoconjugates can be obtained by chemical, enzymatic or other biological methods for systematic studies. However, the structural complexity and diversity of glycans and their conjugates present a major challenge for the synthesis of such molecules. This review summarizes the chemical synthesis methods of oligosaccharides, the application of oligosaccharides in the field of medicinal chemistry according to their related biological activities, and shows the great prospect of oligosaccharides in the field of pharmaceutical chemistry.
[Display omitted]
•We introduced the source and biological activity of oligosaccharides.•We summarized a variety of chemical synthesis methods of oligosaccharides.•We summarized the application of oligosaccharides in the field of medicinal chemistry. |
| doi_str_mv | 10.1016/j.ejmech.2023.115164 |
| format | Article |
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[Display omitted]
•We introduced the source and biological activity of oligosaccharides.•We summarized a variety of chemical synthesis methods of oligosaccharides.•We summarized the application of oligosaccharides in the field of medicinal chemistry.</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2023.115164</identifier><identifier>PMID: 36758451</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Biological activity ; Chemical Sciences ; Chemistry, Pharmaceutical ; Drug research ; Glycoconjugates - chemistry ; Glycosylation ; Humans ; Oligosaccharide ; Oligosaccharides - chemistry ; Polysaccharides ; Synthesis</subject><ispartof>European journal of medicinal chemistry, 2023-03, Vol.249, p.115164-115164, Article 115164</ispartof><rights>2023 Elsevier Masson SAS</rights><rights>Copyright © 2023 Elsevier Masson SAS. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-887f29de7ab4c90cb81d1eb580e28a2aa7dbcdddca4ec322301e57fbc80fd0ba3</citedby><cites>FETCH-LOGICAL-c442t-887f29de7ab4c90cb81d1eb580e28a2aa7dbcdddca4ec322301e57fbc80fd0ba3</cites><orcidid>0000-0001-8493-5812</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejmech.2023.115164$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36758451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03978291$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lv, Zhimin</creatorcontrib><creatorcontrib>Liu, Hongyu</creatorcontrib><creatorcontrib>Hao, Huifang</creatorcontrib><creatorcontrib>Rahman, Faiz-Ur</creatorcontrib><creatorcontrib>Zhang, Yongmin</creatorcontrib><title>Chemical synthesis of oligosaccharides and their application in new drug research</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>Oligosaccharides are the ubiquitous molecules of life. In order to translate human bioglycosylation into clinical applications, homogeneous samples of oligosaccharides and glycoconjugates can be obtained by chemical, enzymatic or other biological methods for systematic studies. However, the structural complexity and diversity of glycans and their conjugates present a major challenge for the synthesis of such molecules. This review summarizes the chemical synthesis methods of oligosaccharides, the application of oligosaccharides in the field of medicinal chemistry according to their related biological activities, and shows the great prospect of oligosaccharides in the field of pharmaceutical chemistry.
[Display omitted]
•We introduced the source and biological activity of oligosaccharides.•We summarized a variety of chemical synthesis methods of oligosaccharides.•We summarized the application of oligosaccharides in the field of medicinal chemistry.</description><subject>Biological activity</subject><subject>Chemical Sciences</subject><subject>Chemistry, Pharmaceutical</subject><subject>Drug research</subject><subject>Glycoconjugates - chemistry</subject><subject>Glycosylation</subject><subject>Humans</subject><subject>Oligosaccharide</subject><subject>Oligosaccharides - chemistry</subject><subject>Polysaccharides</subject><subject>Synthesis</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVoSLZp36AUHZuDt5IsWdpLISxNE1gIgfYsxtI41mJbW8mbkrevFqc59qIBzffPMB8hnzhbc8abr_s17kd0_VowUa85V7yRZ2TFdWOqWij5jqyYEHWlRC0vyfuc94wx1TB2QS7rRisjFV-Rx22PY3Aw0PwyzT3mkGnsaBzCU8zgXA8peMwUJk9LOyQKh8NQAnOIEw0TnfAP9en4RBNmhOT6D-S8gyHjx9d6RX7dfv-5vat2Dz_utze7ykkp5soY3YmNRw2tdBvmWsM9x1YZhsKAANC-dd57BxJdXQ5hHJXuWmdY51kL9RW5Xub2MNhDCiOkFxsh2LubnT39sXqjjdjwZ17YLwt7SPH3EfNsx5AdDgNMGI_ZCq1Vw8vbFFQuqEsx54Td22zO7Em83dtFvD2Jt4v4Evv8uuHYjujfQv9MF-DbAmBx8hww2ewCTg59SOhm62P4_4a_E8aWnw</recordid><startdate>20230305</startdate><enddate>20230305</enddate><creator>Lv, Zhimin</creator><creator>Liu, Hongyu</creator><creator>Hao, Huifang</creator><creator>Rahman, Faiz-Ur</creator><creator>Zhang, Yongmin</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-8493-5812</orcidid></search><sort><creationdate>20230305</creationdate><title>Chemical synthesis of oligosaccharides and their application in new drug research</title><author>Lv, Zhimin ; Liu, Hongyu ; Hao, Huifang ; Rahman, Faiz-Ur ; Zhang, Yongmin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-887f29de7ab4c90cb81d1eb580e28a2aa7dbcdddca4ec322301e57fbc80fd0ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biological activity</topic><topic>Chemical Sciences</topic><topic>Chemistry, Pharmaceutical</topic><topic>Drug research</topic><topic>Glycoconjugates - chemistry</topic><topic>Glycosylation</topic><topic>Humans</topic><topic>Oligosaccharide</topic><topic>Oligosaccharides - chemistry</topic><topic>Polysaccharides</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lv, Zhimin</creatorcontrib><creatorcontrib>Liu, Hongyu</creatorcontrib><creatorcontrib>Hao, Huifang</creatorcontrib><creatorcontrib>Rahman, Faiz-Ur</creatorcontrib><creatorcontrib>Zhang, Yongmin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lv, Zhimin</au><au>Liu, Hongyu</au><au>Hao, Huifang</au><au>Rahman, Faiz-Ur</au><au>Zhang, Yongmin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical synthesis of oligosaccharides and their application in new drug research</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2023-03-05</date><risdate>2023</risdate><volume>249</volume><spage>115164</spage><epage>115164</epage><pages>115164-115164</pages><artnum>115164</artnum><issn>0223-5234</issn><eissn>1768-3254</eissn><abstract>Oligosaccharides are the ubiquitous molecules of life. In order to translate human bioglycosylation into clinical applications, homogeneous samples of oligosaccharides and glycoconjugates can be obtained by chemical, enzymatic or other biological methods for systematic studies. However, the structural complexity and diversity of glycans and their conjugates present a major challenge for the synthesis of such molecules. This review summarizes the chemical synthesis methods of oligosaccharides, the application of oligosaccharides in the field of medicinal chemistry according to their related biological activities, and shows the great prospect of oligosaccharides in the field of pharmaceutical chemistry.
[Display omitted]
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| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 2023-03, Vol.249, p.115164-115164, Article 115164 |
| issn | 0223-5234 1768-3254 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological activity Chemical Sciences Chemistry, Pharmaceutical Drug research Glycoconjugates - chemistry Glycosylation Humans Oligosaccharide Oligosaccharides - chemistry Polysaccharides Synthesis |
| title | Chemical synthesis of oligosaccharides and their application in new drug research |
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