Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata

A supercritical fluid chromatography-based targeted purification procedure using tandem mass spectrometry and molecular networking was developed to analyze, annotate, and isolate secondary metabolites from complex plant extract mixture. This approach was applied for the targeted isolation of new ant...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2017-10, Vol.80 (10), p.2620-2629
Hauptverfasser:	Nothias, Louis-Félix, Boutet-Mercey, Stéphanie, Cachet, Xavier, De La Torre, Erick, Laboureur, Laurent, Gallard, Jean-François, Retailleau, Pascal, Brunelle, Alain, Dorrestein, Pieter C, Costa, Jean, Bedoya, Luis M, Roussi, Fanny, Leyssen, Pieter, Alcami, José, Paolini, Julien, Litaudon, Marc, Touboul, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Chemical Sciences Chikungunya virus - drug effects Chromatography, Supercritical Fluid - methods Crystallography, X-Ray Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Euphorbia - chemistry HIV-1 - drug effects Molecular Conformation Molecular Structure Plant Extracts - chemistry Tandem Mass Spectrometry - methods Virus Replication - drug effects
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