Long-term outcome in 53 patients with homozygous familial hypercholesterolaemia in a single centre in France

Abstract Background and aims Homozygous familial hypercholesterolaemia (HoFH) is a rare inherited condition characterized by elevated plasma low-density lipoprotein-cholesterol (LDL-C) levels, severe, accelerated atherosclerosis and premature coronary heart disease. We evaluated cardiovascular compl...

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Veröffentlicht in:	Atherosclerosis 2017-02, Vol.257, p.130-137
Hauptverfasser:	Bruckert, Eric, Kalmykova, Olga, Bittar, Randa, Carreau, Valérie, Béliard, Sophie, Saheb, Samir, Rosenbaum, David, Bonnefont-Rousselot, Dominique, Thomas, Daniel, Emery, Corinne, Khoshnood, Babak, Carrié, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Angina Pectoris - genetics Angina Pectoris - prevention & control Anticholesteremic Agents - therapeutic use Biomarkers - blood Blood Component Removal Cardiovascular Cardiovascular Diseases - genetics Cardiovascular Diseases - mortality Cardiovascular Diseases - prevention & control Child Child, Preschool Cholesterol Cholesterol burden Cholesterol, LDL - blood Cholesterol-year score Disease-Free Survival DNA Mutational Analysis Early Diagnosis Female France Genetic Predisposition to Disease Heredity Homozygote Homozygous familial hypercholesterolaemia Humans Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - genetics Hyperlipoproteinemia Type II - mortality Hyperlipoproteinemia Type II - therapy Infant Infant, Newborn Kaplan-Meier Estimate Life Sciences Lipoprotein apheresis Male Mutation Myocardial Infarction - genetics Myocardial Infarction - prevention & control Pedigree Phenotype Predictive Value of Tests Receptors, LDL - genetics Retrospective Studies Risk Factors Statin Time Factors Treatment Outcome
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