Cell-Cell Propagation of NF-κB Transcription Factor and MAP Kinase Activation Amplifies Innate Immunity against Bacterial Infection

The enteroinvasive bacterium Shigella flexneri uses multiple secreted effector proteins to downregulate interleukin-8 (IL-8) expression in infected epithelial cells. Yet, massive IL-8 secretion is observed in Shigellosis. Here we report a host mechanism of cell-cell communication that circumvents th...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2010-11, Vol.33 (5), p.804-816
Hauptverfasser:	Kasper, Christoph Alexander, Sorg, Isabel, Schmutz, Christoph, Tschon, Therese, Wischnewski, Harry, Kim, Man Lyang, Arrieumerlou, Cécile
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Caco-2 Cells Cell Communication - immunology Cell Proliferation Dysentery, Bacillary - enzymology Dysentery, Bacillary - immunology Gap Junctions - immunology Gap Junctions - microbiology HeLa Cells Humans Immunity, Innate Interleukin-8 - analysis Interleukin-8 - immunology Life Sciences Listeria monocytogenes Listeria monocytogenes - immunology Listeriosis - enzymology Listeriosis - immunology MAP Kinase Signaling System - immunology Mitogen-Activated Protein Kinases - immunology Mitogen-Activated Protein Kinases - metabolism NF-kappa B - immunology NF-kappa B - metabolism Peptidoglycan - immunology Salmonella typhimurium Shigella flexneri Shigella flexneri - enzymology Shigella flexneri - immunology
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